Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"CSCS"”.
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Exploring Cancer Stem Cells (CSCs) pathways to design novel therapies for glioblastoma treatment
… of an expansion sustained by Cancer Stem Cells (CSCs) that are spared by virtue of their relative quiescence and the expression of drug-effluxing membrane transporters. In this project, we proposed to identify therapeutic agents that efficiently kill GBM-SCs and might be useful to set up more …
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Investigation of Cancer Stem Cells (CSCs)-derived exosomes and their influence on the tumor microenvironment
… and functions of Lung cancer stem cells (LCSCs)-derived exosomes, with focus on the content of typical proteins, microRNAs and cell-to-cell communication. We were able to set up an isolation protocol to obtain the exosomes from LCSCs supernatant. The exosomes have a distinct composition of …
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Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
… cancer is enriched with cancer stem cells (CSCs), which contribute to its high metastatic tendency and resistance to treatments. The formation of CSCs is highly associated with cancer cell epithelial-mesenchymal transition (EMT), which contributes to the plasticity of cancer cells and …
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RADIOSENSITIZING EFFECTS OF THROMBIN PEPTIDE TP508 ON MEDULLOBLASTOMA CANCER STEM CELLS
… a subpopulation of resistant cancer stem cells (CSCs) known to be responsible for tumor recurrence. Therefore, it is important to develop novel non-toxic therapeutics capable of sparing normal cells/tissues to prevent cognitive dysfunctions, while also sensitizing CSCs to radiation therapy in …
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Notch Signaling Is Important in the Survival, Proliferation, and Self-Renewal of the Putative Breast Cancer Stem Cell Population
… stem-like cells, termed cancer stem cells (CSCs), in breast tumors and established cell lines. It has been hypothesized that CSCs are responsible for breast cancer formation, progression and recurrence; therefore, a deeper understanding of the signaling pathways regulating CSC survival will …
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Prostate Cancer Stem Cells: Drug to lerance, Experimental Reconstitution and Castration Resistance
… cells inside a tumor, termed ‘cancer stem cells (CSCs)’, may be the cells responsible for tumor initiation, progression, recurrence, metastasis and therapy resistance. Like CSC studies in other cancer types, it has been reported that PCa also contains CSCs. However, there remain several unresolved …
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Transforming Linear to Reuse Circular Supply Chains
… emerging area of Reuse Circular Supply Chains (CSCs) and present an understanding of relationships between SC design and reuse circularity within the context of single-use plastic packaging. Literature demonstrates that in supply chain design, multiple perspectives can be taken. However, if we …
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Investigation of the anticancer activity and molecular mechanisms of Disulfiram in Glioblastoma Multiforme
… Although the existence of cancer stem cells (CSCs) is still debatable, it is widely accepted that GBM has a small population of cells expressing CSC markers (~1%) that are highly resistant to chemo-radiation therapy. Recent evidence indicates that hypoxia induces cancer stem cell (CSC) …
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Role of Polyphenolic Compounds in Chemoprevention of Breast Cancer Stem Cells
… to control cancer stem cells. Cancer Stem Cells (CSCs) are highly tumorigenic cells involved in carcinogenesis and can cause relapses. MicroRNAs (miRNAs) can act as regulators of CSCs, by controlling stemness and invasion. We postulate that PEBP or its polyphenolic components induce specific …
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ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… overexpression in breast cancer stem-like cells (CSCs) isolated from the MCF7, MDA MB231 and MDA MB231 LM cell lines using cell surface markers (CD24-/CD44+/ESA+). These cells were previously transplanted into the mammary fat pad of nude mice and the results of our limiting dilution analysis …
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Determinants of user adoption of egovernment services: the case of Greek local government
… there are third parties (Citizen Service Centres-CSCs) that operate and play a significant role in the eGovernment context. Nevertheless, their roles in eGovernment acceptance have to be investigated, in addition to other factors. Hence, further research is needed. The ultimate aim of this …
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Targeting survival pathways in cancer stem cells
… and therefore referred to as cancer stem cells (CSCs), has added a further level of complexity to the pathobiology of neoplastic diseases. This uncommon cellular subpopulation has been connected with tumor initiation, metastatization and treatment failure. CSCs are protected against standard …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… of IBC and TNBC have been linked to CSCs and epithelial to mesenchymal transition (EMT), which are critical features of breast cancer progression and metastasis. The clinical challenge faced in the treatment of IBC and TNBC is finding a treatment strategy to target the cancer …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… of IBC and TNBC have been linked to CSCs and epithelial to mesenchymal transition (EMT), which are critical features of breast cancer progression and metastasis. The clinical challenge faced in the treatment of IBC and TNBC is finding a treatment strategy to target the cancer …
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Lgr5 Regulation of Stat3 Signaling and Drug Resistance In Colorectal Cancer
… progression to metastasis. Cancer stem cells (CSCs) are believed to drive relapse because of their capacity to self-renew, acquire resistance mechanisms, and differentiate promoting tumor growth and heterogeneity. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), is a …
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Expression profile of multidrug resistance genes and proteins in cancerous and stem cells
… of a subpopulation of cells - cancer stem cells (CSCs) may be the major obstacle in treating gliomas. CD133 and nestin have been suggested as the markers of CSCs and natural stem cells. The primary focus of this study was to identify CD133+/nestin+ stem-like cells and discover their association …
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Molecular Characterization of Glioblastoma Cancer Stem Cells
… able to initiate and maintain tumors. Although CSCs represent only a small fraction of cells within a tumor, their high tumor-initiating capacity and therapeutic resistance is believed to drive tumorigenesis. Therefore, it is imperative to improve our molecular understanding of the tumor …
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Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer
… of cells, so-called “cancer stem cells” (CSCs), possess the unique biological properties required for tumourigenesis. In addition to tumour initiation, cancer stem cells are held solely accountable for tumour differentiation, tumour maintenance, tumour spread and tumour relapse following …
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A Regional Study on Champlain Sea Clay: Empirical Prediction of Consolidation Parameters and Statistical Characterization of Undrained Shear Strength Based on Historical Geotechnical Data
… on the Ottawa Valley region of Eastern Ontario. CSCs are highly compressible sensitive marine clays, which pose serious risks both with respect to deformation as well as short-term stability behavior. Geotechnical infrastructures placed on CSC are prone to excessive settlement, differential …
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Investigation of the anti-breast cancer efficacy and mechanisms of disulfiram
… anticancer drugs. Cancer stem cells (CSCs) have been thought to be responsible for the chemoresistance. My study demonstrated that mammospheres manifested CSC characteristics and are highly resistant to several first line anti-BC drugs. This may be due to the hypoxia in the centre of …
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