Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"CSCC"”.
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Transforming Growth Factor-Beta Signalling in Human Cutaneous Squamous Cell Carcinoma
… in human cutaneous squamous cell carcinoma (cSCC) in order to identify novel therapeutic targets. Already the second most common form of human non-melanoma skin cancer, the incidence of cSCC has continued to rise at epidemic proportions over the past two decades. Rarely, cSCC can be highly …
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Investigating DNA Methylation Changes in a Preclinical Murine Model of Cutaneous Squamous Cell Carcinoma
… (BCC) and cutaneous squamous cell carcinomas (cSCC), with the latter being responsible for the majority of NMSC deaths. Incidence rates for NMSC are rising due to increased exposure to UV radiation, caused by active sun-seeking behaviour and increased cumulative sun-exposure in aging population …
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Targeting mutant p53 in cSCCs
Cutaneous squamous cell carcinoma (cSCC) is a type of non-melanoma skin cancer that is the 4th most common cancer registration in Scotland after BCC, lung and breast cancer. Over 30,000 cSCC incidences are reported each year in the United Kingdom. In addition, around 1 in 4 skin cancer deaths in …
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Human papilloma virus in conjuctival squamous cell carcinoma at the university teaching hospital and Lusaka adventist eye hospital Zambia.
… to conjunctival squamous cell carcinoma (CSCC) and has been documented in studies originating from different parts of the world. In Zambia, eye cancers are on the increase and between 2005 and 2009 they were ranked number three (3) among the top five (5) cancers of which conjunctival …
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Flower Isoforms Increase Expression in Response to Cellular Stress and Modulate S100 Expression in Cutaneous Squamous Cell Carcinoma Cells
… in humans, cutaneous squamous cell carcinoma (cSCC), affects more than 1 million patients a year in the United States. cSCC arise from keratinocytes of the epidermis or hair follicles. Current treatments are limited, especially for pre-cancerous lesions. Homeostasis and differentiation of the …
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Towards development of new strategies for inhibiting skin cancer progression
… (MMPs).<br/><br/>Cutaneous SCC (cSCC) is the second most common skin cancer, comprising 20% of NMSC. cSCC arise from the aberrant proliferation of keratinocytes, although this process is also dysregulated in other skin diseases. Wingless-Type MMTV Integration Site Family …
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The Role of Tau in Epidermal Stratification and Differentiation and its Implications in Skin Cancer
… function in cutaneous squamous cell carcinoma (cSCC). Methods: Immunostaining was used to investigate tau expression in clinical samples, 2D cultures and 3D skin equivalents. To explore the functional significance of tau during keratinocyte differentiation and stratification, siRNA and shRNA …
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Design of Peptide Ligands for 14-3-3ε, and Exploring the Role of Residue Types in Ligand Recognition by 14-3-3 Proteins
… In cutaneous squamous cell carcinoma (cSCC), overexpression of the 14-3-3ε isoform is associated with suppression of apoptosis. Like 14-3-3ε, the protein phosphatase cell division cycle 25 A (CDC25A) is over expressed and mislocalized from nucleus to cytoplasm in cSCC. The …
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Characterization of the expression of angiogenic factors in the feline placenta during development and in feline cutaneous squamous cell carcinoma
… in cutaneous squamous cell carcinoma (CSCC), a common skin cancer with major economic and medical impacts in humans and veterinary species. The creation of a new blood supply is essential for growth and metastasis of many tumor types. The goal of this study was to measure expression of …
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Investigation of HPV16-related genomic alterations in cervical squamous cell carcinoma
… expression in cervical squamous cell carcinoma (CSCC) tumors. The genomic analysis involved clinical and genomics data analysis using bioinformatics and statistical methods. The Cancer Genome Atlas Program (TCGA) resource was used to download Cervical Squamous Cell Carcinoma and Endocervical …
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Supervised Machine Learning Under Test-Time Resource Constraints: A Trade-off Between Accuracy and Cost
… and Cost Sensitive Cascade of Classifiers (CSCC), which share a common strategy that trades-off the accuracy and the amortized test-time cost. CSTC introduces a tree structure and directs test inputs along different tree traversal paths, each is optimized for a specific sub-partition of the …
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The Role of Dermal Architecture in Wound Healing and Tumour Differentiation
… models to gain new perspectives in the study of cSCC. Understanding the processes which lead to cSCC in RDEB will help in the development of new molecular targets for future therapeutic purposes.
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Statistical assessment of cervical squamous cell carcinoma attributable risk to HIV-Infected Women in Zambia
… women and there is strong association between CSCC and HIV among women in Zambia.
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Statistical assessment of cervical squamous cell carcinoma attributable risk to HIV-Infected Women in Zambia
… women and there is strong association between CSCC and HIV among women in Zambia.
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Optimising Recording & Stimulation Performance of Neuronal Microelectrode Arrays through Macroporous Conducting Polymer Modification
… increased cathodic charge storage capacity (CSCc) and charge injection limits (CIL). Alongside microelectrode modification, we hypothesise that the refinement of recording instrumentation (amplifier and digitiser) required to acquire signals from MEA devices will compliment reduced thermal …
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The Roles of Ca2+ and cAMP in the Nematocyst Discharge of the Sea Anemone Tentacle
… the cnidocyte/supporting cell complex (CSCC) controls nematocyst discharge.</p> <p>This project explores the chemoreceptor signaling pathway controlling nematocyst discharge from tentacles of the sea anemone, <em>Aiptasia pallida</em>. Chemoreceptors respond to N-acetylated sugars, such …
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A study of somatic cell concentrations in milk of laboratory mice
… or HSCC, low line or LSCC) and one control line (CSCC) of mice. Distribution of milk SCC in mice was 4 to 5 times the distribution in Holsteins. The shape of the lactation curve of mice was similar to that of Holsteins with maximum yield at day 7 (2.06 gms). The phenotypic regression of lactation …