Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"CRPC"”.
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Tmprss2-Erg Regulation Of Androgen Biosynthetic Enzyme Expression, Dht Synthesis, And Androgen Receptor Activation In Prostate Cancer
… of castration-resistant prostate cancer (CRPC). Several enzymes responsible for androgen biosynthesis have been shown to be overexpressed in CRPC, thus, contributing to CRPC in a castrated environment. Although intratumoral androgen synthesis is thought to contribute to the development and …
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TMEFF2 is an epigenetic modulator that promotes androgen independent growth in castration-resistant prostate cancer cells
… castration resistant prostate cancer (CRPC), during which the PCa cells develop the ability to grow in androgen depleted conditions. The androgen receptor (AR) plays a vital role in prostate development and homeostasis, and the deregulation of AR drives PCa tumorigenesis and progression …
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Therapeutic Effects and Targeted Delivery of Eupenifeldin in Castration-Resistant Prostate Cancer
Castration-resistant prostate cancer (CRPC) poses a major therapeutic challenge, as it often fails to respond to standard treatments such as taxane-based chemotherapies, androgen receptor pathway inhibitors, and radioligand-based approaches1–4. Despite these treatments, CRPC remains incurable, and …
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Identification and Targeting of Downstream Ar-Camkk2-Mediated Mechanisms For The Treatment of Advanced Prostate Cancer
… targets in castration-resistant prostate cancer (CRPC).</p> <p>First, I identified Unc-51 like autophagy activating kinase 1 (ULK1), an important autophagic initiator, as one of downstream effectors regulated by AR-CAMKK2-5’-AMP-activated protein kinase (AMPK) signaling. CAMKK2-induced protective …
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Intratumoral Sting Activation Sensitizes Poorly Immunogenic Cancers to Checkpoint Blockade Immunotherapy
… types. Castration resistant prostate cancer (CRPC) and pancreatic adenocarcinoma (PDAC) are two common lethal cancers that remain refractory to checkpoint blockade, requiring development of new therapeutic approaches to promote responsivity in patients with these diseases. Both CRPC and PDAC …
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Prostate Cancer Stem Cells: Drug to lerance, Experimental Reconstitution and Castration Resistance
… dependent to the lethally castration resistant (CRPC) stage remains enigmatic, and the cells responsible for CRPC development have not been identified. Herein, we have found a putative cell population, ALDH<sup>+</sup>CD44<sup>+</sup>α2β1<sup>+</sup> PCa cells that may represent a cell-of-origin …
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Detection of AR gene rearrangements and regulation of AR variant-driven prostate cancer models
… disease, castration-resistant prostate cancer (CRPC). The development of CRPC is usually due to a variety of AR reactivation mechanisms including AR amplification, AR gene rearrangements, AR ligand binding domain mutations, altered expression of AR coregulatory factors, and the emergence of AR …
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Quantitative analyses to study tumor clones dynamics and tumor heterogeneity
… men with castration resistant prostate cancer (CRPC) might be informative in terms of treatment decision. Here I present analytical work on two approaches relevant to the characterization of intra-patient heterogeneity and applied to unpublished CRPC patients sequencing data. The first is based …
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The role of BET proteins in castration-resistant prostate cancer dissemination
… castration-resistant prostate cancer (mCRPC). Here, we examined prostate cancer cell lines that model common CRPC subtypes, each with different AR composition, and focused on novel regulators of tumor progression, the Bromodomain and ExtraTerminal (BET – BRD2, BRD3 and BRD4) family of …
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Impact of dietary tomato intake on prostate cancer throughout the course of disease development and progression in a transgenic mouse model
… and becomes known as castration-resistant PCa (CRPC), a terminal and treatment-resistant disease. Second only to potatoes, tomatoes are widely consumed in a variety of forms throughout the United States. Abundant epidemiological and pre-clinical evidence exists to show that physiologically …
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Dietary tomato carotenoids and β-carotene-15,15'- dioxygenase (Bco1) genotype alter androgen metabolism, lipid metabolism, and prostate cancer progression in mice
… tomato on castration-resistant prostate cancer (CRPC), which constitutes the late and lethal stage of human PCa. Therefore, we used a mouse model, the transgenic adenocarcinoma of the mouse prostate (TRAMP), to probe this gap in the literature. TRAMP mice (n=30/treatment) were treated with either …
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Germline HOXB13 G84E Mutation Inhibits MEIS1-HOXB13 Driven Tumor Suppression in Prostate Cancer
… to Castration Resistant Prostate Cancer (CRPC), emphasizing the need in identifying and understanding other signaling axis. Germline mutations in the developmental transcription factor HOXB13 are nonspecifically associated with early onset and potentially rapid progression of prostate …
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Antioxidant Programs Are Essential for Enzalutamide-Resistant Prostate Cancer
… PCa cells and castration-resistant PCa (CRPC) tumors had dramatically higher levels of both basal and inducible levels of reactive oxygen species (ROS) than either enzalutamide-sensitive PCa cells or primary therapy-naïve tumors, respectively. Unbiased metabolomic evaluation identified …
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Investigation of the role of Col4a1 and Itga11 in enzalutamide resistance of prostate cancer cells
… into Castration-Resistant Prostate Cancer (CRPC). CRPC is very likely to metastasise to bone, which worsens morbidity and mortality. Metastatic CRPC (mCRPC) is currently incurable and accounts for over 90% of PCa-related deaths. Tumour-associated macrophages (TAMs) can promote ADT resistance …
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Grk3 Connects Angiogenesis and Neuroendocrine Differentiation In Prostate Cancer By Activating Hdac2 That Epigenetically Represses Tsp1 and Rest
… subset of castration-resistant prostate cancer (CRPC), found in ~20% lethal CRPC. The mechanisms underlying the progression of PCa to NEPC are still largely unclear, and new drug targets are desperately needed. NEPC is highly vascularized (angiogenic) and characterized by high expression of …
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Characterisation of Androgen Receptor Signalling and Metabolism in Prostate Cancer
… known as castrate-resistant prostate cancer (CRPC), for which very few therapies exist. Therefore, understanding and characterising AR signalling may aid in the development of novel therapeutics. Fused in Sarcoma (FUS) (a co-regulator protein of the AR) and Hox Transcript Antisense Intergenic …
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Techniques for comparing efficacy and cost-effectiveness of cancer therapies, and improved inference tools
… advanced castration-resistant prostate cancer (CRPC). Prostate cancer is the most commonly diagnosed cancer. It eventually progresses to CRPC. CRPC is one of the leading cause of cancer-related deaths among men in developed countries. Two novel androgen receptor pathway inhibitors, abiraterone …
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Phage Display Library Screening For Psa-/Lo Prostate Cancer Cell-Binding Peptides
… in castration-resistant prostate cancer (CRPC). Our lab has provided evidence that the phenotypically undifferentiated PCa cell population expressing low levels or no prostate specific antigen (i.e., PSA<sup>-/lo</sup>) is enriched in prostate cancer stem cells (PCSCs) that can long-term …
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Integrative Bioinformatics Approaches to Elucidating Prostate Cancer Cell Heterogeneity, Plasticity, and Treatment Response
… and become enriched in castration resistant PCa (CRPC). Our lab has demonstrated that the prostate cancer stem cells (PCSCs) are enriched in the phenotypically undifferentiated PCa cell population that lacks the expression of differentiation marker prostate-specific antigen (PSA). Our work has …
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The role of tomato and lycopene consumption on prostate carcinogenesis and prostate cancer treatment
… growth of castration-resistant prostate cancer (CRPC). This aggressive and often lethal stage of PCa occurs after the prostate tumor acquires mutations to sustain growth despite androgen deprivation therapy (ADT). We hypothesized that tomato or lycopene products would reduce the emergence of …
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