Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"CROP-seq"”.
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Master regulators of neuronal maturation in NGN2 reprogrammed iPSC-derived iNeurons
… prediction tools and a dataset combining ATAC-seq and RNA-seq analysis of a granular time-course experiment during NGN2 reprogramming, in the presence and absence of glia. Predicted TFs were found to also be expressed during human cortical development and mutations in them are enriched in …
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CRISPR activation screening at single-cell transcriptomic resolution: discovering new regulators of zygotic genome activation
… to perform a CRISPRa screen with single-cell RNA-sequencing read-out. Specifically, I test CRISPRa in mouse embryonic stem cells (mESCs) using two well characterised markers of ZGA as targets and, subsequently, I develop and validate a method for detecting short guide RNA (sgRNA) molecules in …