Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"CRKL"”.
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The role of adaptor proteins Crk and CrkL in lens development
… not been identified. Adaptor proteins Crk and CrkL are SH2- and SH3-containing proteins that transduce signals from upstream tyrosine phosphorylated proteins to downstream effectors, including Ras, Rac1 and Rap1, which are important for cell proliferation, adhesion and migration. Underlying …
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Targeting Breast Cancer With Bacteriophage Associated Silicon Particles
… display significant targeting efficiency of the CRKL targeted BASP. However, in shear rates relevant to the tumor microvasculature (10s<sup>-1</sup>), CRKL targeted BASP demonstrated 2-fold higher adhesion than S1MP to endothelial cells. These results were further exaggerated in <em>in vivo</em> …
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Generation and Characterization of Human Blood-Brain Barrier Models for Investigating Neuropsychiatric Disorders and Tumor Metastasis
… significantly disrupted. It was also found that CRKL, a gene within the 22q11.2 DS deletion region, contributes to the deficit. The CRKL is a major substrate of the Abl tyrosine kinase, and the Abl/CRKL signaling pathway is critical for endothelial barrier functions. Imatinib, an FDA-approved …
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Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling and Cancer Cell Invasion
… the FAK/Src pathway through direct targeting of CRKL, an integrin adaptor molecule. Our studies suggest that CRKL is critical in enhancing the outside-in signaling through Itgβ1 but also involved in the inside-out signaling by maintaining the cell-matrix contact required for continuous cell …
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Substratspezifität und Signaltransduktion zellulärer und onkogener Abl-Tyrosinkinasen
… in Proteinkomplexen mit dem Adapterprotein CRKL, ein Protein, das in Bcr-Abl-transformierten Zellen konstitutiv Tyrosin-phosphoryliert ist, nachgewiesen werden. Des weiteren wurde gezeigt, daß in den Tel-Abl exprimierenden Zellen die Adapterproteinen c-CrkII und CRKL phosphoryliert sind und …
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Quantitative Proteinexpressionsanalysen in den klinisch-pathologischen Subtypen Gastrointestinaler Stromatumoren (GIST)
… PKC-alpha, phospho-PKC-alpha, SRC, phospho-LYN, CRKL, AKT-1, phospho-AKT-1, ERK-2, FAK, PYK-2 und cyt-PP2A wurde in Abhängigkeit von den klinisch-pathologischen Parametern Lokalisation, Morphologie, Tumorgröße, Mitosenanzahl und Mutationsstatus untersucht.Ergebnisse: Das 167 GIST-Fälle umfassende …
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Upstream Migration Under Shear Flow: Force Generation and Molecular Regulation
… of this force program, CRISPR/Cas9 knockout of CrkL, an upstream LFA-1 signaling adaptor, and L-plastin, a hematopoietic actin crosslinker, was performed in KG1a cells. Both knockouts abolished upstream migration while leaving all ten quantified traction force metrics unchanged, including under …
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Studies of the Mechanisms of Reverse Signaling by CD40L
… binding array identified Abl2, CRK, and CRKL as candidates that interact with the highly conserved phosphorylated tyrosine residue at position 5 (Y5) in the CD40L cytoplasmic domain. To assess structural requirements, CD40L constructs with either a cytoplasmic domain deletion or a Y5F …
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Regulation of inflammatory TLR signalling by the BCAP adaptor
… a number of proteins including Grb2 and CRKL as new adaptor proteins in the BCAP interactome. Subsequent validation in mammalian cells via co-immunoprecipitation showed that Grb2 is a direct interaction partner of BCAP. Further characterization of all SH2 and SH3 domain-containing …
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Molecular mechanisms of signal transduction in neutrophil chemotaxis
… spatial activation of Rap1 by recruiting the CrkL/C3G protein complex to the leading edge. Together, these results provide novel mechanistic insights into the poorly understood signaling network that controls leading edge adhesion during neutrophil chemotaxis. In my second research project, we …
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Investigation of Copy Number Variation in South African Patients with Congenital Heart Defects
… known to be causal for CHD (GATA4, TBX1, FLT4, CRKL, NSD1, and B3GAT3), and four CNVs encompassing candidate genes likely to play a role in the development of CHD (DGCR8, JARID2, KDM2A, and FSTL1). The CNVs were identified in nine unrelated individuals: five of the CNVs were classified as …
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In vivo pool-based shRNA screens to identify modulators of disease progression in hematopoietic malignancies
… suppression of these genes, which included Rac2, CrkL, and the poorly characterized actin monomer binding protein Twf, impaired lymphoma progression and tumor cell dissemination to sites of terminal metastatic disease. Additionally, suppression of Rac2 and Twf improved chemotherapeutic outcome, …
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Die Hämatopoetische Progenitor Kinase (HPK) 1 und NFAT-Transkriptionsfaktoren unterstützen die Apoptose von T-Lymphozyten
… den Adaptorproteinen Nck, Crk, Gads, Grb2, Grap, CrkL sowie SLP-76 gezeigt. Für die Aktivierung der nach TZR-Stimulation in den Lipid-Rafts lokalisierten HPK1 sind sowohl Lck als auch ZAP-70 notwendig [Liou et al., 2000; Liu et al., 2000a; Ling et al., 2001]. Diese Daten legen eine mögliche …
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Development and Validation of Quantitative PCR Assays for DNA-Based Newborn Screening of 22q11.2 Deletion Syndrome, Spinal Muscular Atrophy, Severe Combined Immunodeficiency and Congenital Cytomegalovirus Infection
The development of new high throughput technologies able to multiplex disease biomarkers as well as advances in medical treatments has lead to the recent expansion of the newborn screening panel to include DNA-based targets. Four rare disorders; deletion 22q11.2 syndrome and Spinal Muscular Atrophy …