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Showing 1 to 1 of 1 for “"CRISPRi chemical-genetics"”.
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A Chemical-Genetic Map of Drug Resistance in Mycobacterium Tuberculosis
… in Mtb using a novel CRISPR interference (CRISPRi)-based chemical genetics platform. Our lab developed a CRISPRi library containing 100,000 unique knockdown strains and treated this library with a panel of some of the most important antitubercular drugs. The fitness of each mutant in the …