Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"CRISPR Gene editing"”.
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CRISPR gene editing for Cystic Fibrosis: targeting the G542X mutation with base editor engineered virus-like particles
Cystic Fibrosis (CF) is a severe genetic disorder affecting hundreds of thousands of individuals worldwide. Approximately 10% of CF patients currently lack treatment options beyond symptomatic care and face a reduced life expectancy. CRISPR-based gene editing offers the potential for a cure, by …
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Symbiotic Shift: Transcultural Explorations of Community-Guided CRISPR Biotechnology Development
… (New Zealand) to spearhead community-guided CRISPR biotechnology development— a new way of creating the next generation of CRISPR gene editing biotechnologies that values cultural knowledge and intentionally seeks guidance from the communities that these biotechnologies may impact in the far …
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Molecular Mechanisms by Which HSP90 Inhibition in the Spinal Cord Enhances Opioid Receptor Signaling
… and EGFR colocalized with CGRP. We further used CRISPR gene editing to knockdown AMPK in CGRP neurons, which was sufficient to enhance opioid antinociception without HSP90 inhibition. When we knocked down EGFR in CGRP expressing neurons however, there was no enhancement, even though there …
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Investigation of Proliferation Suppressors In Genetic Fitness Screens
<p>Innovation of CRISPR gene-editing technology has provided scientists genome manipulation tools that allowed rapid advancement of scientific capabilities and thus improved our ability to systematically study mammalian genetic functional profiles. Genome-wide CRISPR knockout screens conducted in …
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Development of gene therapies for treatment of neurological disorders
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Understanding the intracellular signalling pathways activated by lipid nanoparticle delivery of mRNA
… efficacy of mRNA therapies. Furthermore, CRISPR gene editing technology was deployed to delete expression of MYD88 and TICAM1, downstream adaptor proteins of TLRs, where deletion of MYD88 reduced the LNP/mRNA induced cytokine response suggesting that TLR signalling has a role in LNP/mRNA …
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Building a bridge between biophysics and neurobiology: A synergic approach to develop Alzheimer’s disease translational models and research tools
… disease (AD) is the most prevalent neurodegenerative disorder, accounting for 60-70% of dementia cases diagnosed worldwide. The impact of AD is rapidly increasing, with deaths more than doubling from 2000 to 2021. As populations age, especially in industrialized nations, the socio-economic …
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CRISPR Cas9 targeted single nucleotide change at the (+15) loci of the alpha-lactalbumin gene
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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The Interrogation of Cas9 Aptamers and sgRNA Structures Through SELEX
<p>While much of the current focus on advancing CRISPR-Cas9 editing revolves around the engineering of Cas9, the interrogation and evolution of sgRNA scaffold, in addition to novel Cas9 binding RNAs, represent another echelon of development and therapeutic potential. Currently, the majority of …