Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"CRISPR Cas9 genetic screens"”.
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Functional Genomic Studies of Cancer Immune Evasion Using In Vitro and In Vivo CRISPR/Cas9 Genetic Screens
… of high-throughput technologies. The advent of CRISPR/Cas9 genetic screens has revolutionised our ability to interrogate the cancer genome and identify its genetic vulnerabilities. With these in mind, I have carried out pooled in vitro and in vivo CRISPR/Cas9 genome-wide genetic screens, in …
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Dissecting the Roles of Cancer Cell Lipid Metabolism in Tumor Progression and Immune Evasion
… we designed and implemented loss of function CRISPR-Cas9 genetic screens to identify lipid metabolic dependencies in cancer cells growing under lipid peroxidation or immune pressure. Cancer cells rewire their metabolism and rely on endogenous antioxidants to mitigate lethal oxidative damage to …
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Regulation of Protein Degradation at the Endoplasmic Reticulum
… using a combination of fluorescent reporters, genetic approaches, and cellular assays, I determine the role of hypoxia in the regulation of cholesterol synthesis, and also characterise the ubiquitination machinery for an ERAD pathway involving the degradation of misfolded cytosolic proteins. …