Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"CRH"”.
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mRNA-Expression des CRH-Systems in menschlichen schwangerschaftsspezifischen Geweben
… letzten Jahre deuten auf eine zentrale Rolle von CRH bei der hormonellen Steuerung der menschlichen Geburt. <br>In dieser Arbeit wurde die mRNA-Expression von CRH, UCN,CRH-BP sowie der CRH-R1 bzw. 2) an menschlichen schwangerschaftsspezifischen Geweben, die bei Schnittentbindungen gewonnen wurden, …
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Mediating role of corticotropin-releasing hormone (CRH) in anxiety and ischemia: Behavioural and physiological correlates
Corticotropin-releasing hormone (CRH) has been considered the quintessential 'stress' neuropeptide, as it mediates stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis and produces behavioural and autonomic responses analogous to natural stressors. However, the role of CRH in …
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Non-canonical Activation of CREB/crh-1 Mediates Neuroprotection in a <i>Caenorhabditis elegans</i> Model of Excitotoxic Necrosis
<p>Excitotoxicity, which is a major cause of neurodegeneration in brain ischemia, can also activate neuroprotective pathways. A frequently suggested neuroprotective cascade involves the activation of the transcription factor CREB by its phosphorylation, but on its own this mode of CREB activation …
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Identification and Characterization of Developmentally Regulated Components of the Stress Axis in Petromyzon Marinus
… elements of the Corticotropin releasing hormone (CRH) receptor-ligand system (CRH system) have been identified in invertebrate species and suggest the CRH system has existed, in some form, for approximately a billion years. It is theorized that vertebrates inherited components of the CRH system …
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Corticotrophin Releasing Hormone Modulation of Feed Intake, Gastric Motility, and Behavior in Low and High Body Weight Selected Lines of Chickens
… injection of corticotrophin releasing hormone (CRH) and related compounds on appetite, behavior, and gastric motility in lines of chickens, one selected for low body weight (LWS) and the other high body weight (HWS), was determined. Nucleotide sequence and expression patterns of the CRHr2 …
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Modulation of Prefrontal Cortex activity and sociability by local interneurons expressing corticotropi-releasing hormone
… enriched with corticotropin-releasing hormone (CRH), generated using these established frameworks. Molecular profiling using Translating Ribosome Affinity Purification (TRAP-seq) predicted an elegant, bimodal postsynaptic mechanism for CRH neuron modulation of both pyramidal cells and …
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Diverse Immune Responses Mediated by Beta-Adrenergic and Corticotropin-Releasing Hormone Receptors in a Model of Pneumococcal sepsis
… and corticotropin-releasing hormone (CRH) on immune responses involved in the pathogenesis of Streptococcus pneumoniae (S. pneumoniae) infection implementing both in vitro and in vivo methodology. Dendritic cells play a pivotal role in antigen presentation and cytokine production, …
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Neuroendocrine Consequences of Binge Alcohol Exposure During Peri-Puberty on Functioning of the Hypothalamo-Pituitary-Adrenal (HPA) Axis
… response. Corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) localized in the paraventricular nucleus (PVN) of the hypothalamus are the major neuropeptides involved in modulating HPA axis responses to stress. Corticosterone (CORT) in rodents, and cortisol in humans, is a …
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Lesioning of the Nucleus of the Hippocampal Commissure Followed by Food Deprivation Stress in Birds Demonstrates Simultaneous Involvement in both the Hypothalamo-Pituitary-Adrenal Axis and the Hypothalamo-Pituitary-Thyroid Axis
… the HPA axis corticotropin releasing hormone (CRH) is a major regulator and driving hormone. A structure named the nucleus of the hippocampal commissure (NHpC) has been found to contain CRH neurons and also these neurons respond to early food deprivation stress significantly prior to the …
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Μελέτη των σχέσεων δομής-δραστικότητας αναλόγων του παράγοντος απελευθερώσεως της κορτικοτρόπου ορμόνης (CRF)
Η Ορμόνη Απελευθερώσεως της Κορτικοτροπίνης (CRH) είναι ένα νευροπεπτίδιο, υπεύθυνο για τις ενδοκρινικές, αυτόνομες και ανοσολογικές αντιδράσεις καθώς και τις αντιδράσεις συμπεριφοράς των θηλαστικών απέναντι στην υπερένταση (stress). Βασικός στόχος της παρούσης ερευνητικής εργασίας είναι ο …
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Alterations of the Corticotropin Releasing Hormone Receptor System Following Early Life Stress and Ethanol Self-Administration in Rhesus Monkeys
… alcohol abuse. Corticotropin-releasing hormone (CRH), a primary mediator of the stress response in the brain, plays a regulatory role in ethanol (EtOH) consumption. The goal of this thesis was to identify how ELS and EtOH drinking affected hypothalamic-pituitary-adrenal (HPA) axis function and …
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A central medullary circuit regulating REM sleep and pontine waves
… expressing corticotropin-releasing-hormone (CRH) with a dual role in regulating both REM sleep and P-waves in mice. Calcium imaging revealed that dmM CRH neurons are selectively activated during REM sleep, and their activity within REM sleep episodes specifically correlates with P-waves and …
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Sonic hedgehog signaling pathway in normal and adenomatous pituitary
… ACTH secretion effect is synergistic with CRH. Shh stimulation increases CRH-R1 levels, up-regulating so the response of corticotrophs to CRH. At the same time, Gli1 is not only activated by Shh, but also by CRH and PKA. Gli1 itself activates POMC-transcription and acts in parallel upstream …
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Elucidating the regulation and function of circRNAs
… of two age-regulated circRNAs expressed from the crh-1 gene in the nematode C. elegans. Using CRISPRCas9, we generated intronic deletions that completely abolished crh-1 circRNAs without interrupting linear crh-1 mRNA expression. Remarkably, we found thatelimination of these circRNAs increased …
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Estrogen Regulation of the Pregnant Baboon Placental 11β-Hydroxysteroid Dehydrogenase (11β-HSD)-Catalyzed Metabolism of Cortisol and Cortisone and Its Effect on the Development of the Fetal Hypothalamic-Pituitary-Adrenal Axis
… in hypothalamic corticotropin-releasing hormone (CRH). CRH protein and CRH mRNA at mid-gestation were similar to concentrations in fetal baboons of late gestation and were not altered in fetuses in which the mother was treated with estradiol. In conclusion, the onset of fetal adrenal steroidogenic …
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The FitzHugh-Nagumo model dynamics with an application to the hypothalamic pituitary adrenal axis
… the neural firing of cortopin releasing hormone(CRH) in the hypothalamus to cortisol secretion in a deterministic manner. I lay the groundwork to construct a more comprehensive model, relating CRH, Adrenocorticotropic hormone (ACTH), and cortisol. I start with one of the existing cortisol …
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Maternal High-Salt Diet During Pregnancy in Sprague Dawley Rats Programs Exaggerated Stress-Induced Blood Pressure and Heart Rate Responses in Adult Female Offspring
… for corticotropin releasing hormone (CRH) and radioimmunoassay for corticosterone. In order to determine the contribution of gene expression to differences seen, total brain RNA was analyzed with microarray. Rats were injected with a ganglionic blocker and an adrenergic receptor …
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Differential appetite regulation in lines of chickens selected for high and low juvenile body weight: the role of beta-MSH
… astressin, a corticotrophin releasing hormone (CRH) receptor antagonist, did not attenuate the effects of beta-MSH in either line suggesting that the altered stress response may not be acting via CRH receptors. When beta-MSH was co-administered with HS014, a highly selective antagonist for the …
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The activity and functioning of the hypothalamic-pituitary-adrenal axis of the red deer stag (cervus elaphus)
… of ACTH₁₋₂₄ (0.04 IU kg⁻¹ live weight), CRH (25 ng kg⁻¹ live weight) and dexamethasone (37 μg kg⁻¹ live weight) were compared in castrated (n=6) and entire (n=6) male deer during the breeding season. A higher level of HPA axis basal activity and adrenal responsiveness to ACTH was seen in …
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Ion channels and electrical excitability in native murine anterior pituitary corticotrophs
… integrate stress-induced stimulatory signals (CRH and AVP) from the brain together with the negative feedback control from circulating glucocorticoid hormones to coordinate adrenocorticotrophin hormone (ACTH) secretion. Previous studies have classified pituitary corticotrophs as both endocrine …
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