Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CREBBP"”.
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Induced Cytotoxicity In Crebbp/Ep300Mut Head and Neck Squamous Cell Carcinoma
<p><strong>INDUCED CYOTOXICTY IN <em>CREBBP</em>/<em>EP300</em>mut HEAD AND NECK SQUAMOUS CELL CARCINOMA</strong></p> <p>Thomaia Pamplin</p> <p>Advisor: Curtis Pickering, Ph.D.</p> <p>Background: Head and neck squamous cell carcinoma HNSCC is the most common malignancy in the head and neck. Most …
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Modelling the effect of loss of function CREBBP mutations in the evolution and treatment of B cell acute lymphoblastic leukaemia (B-ALL)
… In this thesis I seek to understand the role of CREBBP mutations in the context of B-ALL. These mutations are conserved among different subtypes of B-ALL including hypodiploid (which have a poor prognosis) and have been found in diagnosis and relapse clones. CREBBP mutations tends to coassociate …
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P4HB TARGETING HALTS TUMOR GROWTH AND RE-SENSITIZES RESISTANT MELANOMA CELLS TO DABRAFENIB AND TRAMETINIB STANDARD-OF-CARE THERAPY VIA IRE1-⍺ ACTIVATION AND AKT DOWNMODULATION
… two candidates, namely CREB-binding protein (CREBBP) and Prolyl 4-Hydroxylase Subunit Beta (P4HB), whose inhibition reduced tumor growth in vivo and increased overall survival of A375-DT but not of A375 parental cells, suggesting a putative point of intervention in resistant tumors. …
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Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… and its close paralogue CREB-binding protein (CREBBP, aka CBP) are well-known transcriptional coactivators that have intrinsic lysine acetyltransferase activity. The functions of p300/CBP largely rely on their capabilities to bind to chromatin and to acetylate the histone substrates. However, …
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RNA Helicase 1 interacts with an ABCRNAi Transporter: Genetic Interactions with haf-6
… mRNP granules, and also associates with BRCA1, CREBbp or SMN1 and the RNA polymerase II complex, phosphorylated histones (H2AFX). RHA affects a number of different biological activities, including CRD-mediated mRNA stabilization, RNA splicing, translation, and transcription. It also has been …
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Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling
… translocation positive FLs were enriched for *CREBBP*, *KMT2D*, *EZH2*, but lacked *TET2*, *CD274* and *IGLL5* mutations, while *BCL2* translocation negative FL including those with *BCL6* translocations displayed few differences from EMZL and DLBCL. There were also few differences in the …