Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"CREB-Binding Protein"”.
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Phosphorylation of Glucocorticoid Receptor tau1c Transactivation Domain Enhances Binding to CREB Binding Protein (CBP) TAZ2 and a Microfluidic, High Throughput Protein Crystal Growth Method for Microgravity
… cysteine rich fragment (CH3) of the co-activator CREB binding protein (CBP). Because CH3 overlaps the CBP transcriptional adaptor zinc binding (TAZ) 2 domain, implicated in phosphorylation dependent binding to other unstructured transcription factor domains, we investigated if GR interacts with …
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Conformational Analysis of Disordered Proteins Using H/D Exchange Mass Spectrometry
Intrinsically disordered proteins (IDPs) represent a growing area of scientific interest. The prevalence of IDPs within the proteomes of complex organisms and the importance of these proteins in cellular functions has become apparent. The application of hydrogen/deuterium exchange mass spectrometry …
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Controlling Gene Expression with Synthetic Molecules
… are minimally composed of two domains, a DNA-binding domain (DBD) and an activation domain (AD). Several synthetic DBDs capable of recognizing DNA in a sequence specific manner have been reported in the literature. Furthermore, studies have demonstrated that coupling of these synthetic DBDs to …
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Investigation of the Role of Histone Acetylation in Hippocampus-Dependent Memory Formation
… post-translational modification of existing proteins may be sufficient for short-term memory, creation of a long-term memory requires de novo gene expression after learning. The ability to express genes is regulated by association of DNA with histone proteins into a chromatin complex. Chapter …
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Studio delle modificazioni post-traduzionali della proteina AIRE e dell’effetto sulla sua attività trascrizionale, stabilità e localizzazione cellulare
The AIRE protein plays a remarkable role as a regulator of central tolerance by controlling the promiscuous expression of tissue-specific antigens in thymic medullary epithelial cells. Defects in the AIRE gene cause the autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy, a rare disease …
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Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… including transcription coactivators. The p300 protein and its close paralogue CREB-binding protein (CREBBP, aka CBP) are well-known transcriptional coactivators that have intrinsic lysine acetyltransferase activity. The functions of p300/CBP largely rely on their capabilities to bind to …
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The Role of CREB in Social Isolation and Natural Reward Behavior
The role of CREB (cyclic AMP Response Element Binding protein) has been known to play a role in complex behaviors such as learning and memory, drug reward and depression. The work presented in this dissertation examines the role of CREB in an inactive stress paradigm, social isolation. Social …
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P4HB TARGETING HALTS TUMOR GROWTH AND RE-SENSITIZES RESISTANT MELANOMA CELLS TO DABRAFENIB AND TRAMETINIB STANDARD-OF-CARE THERAPY VIA IRE1-⍺ ACTIVATION AND AKT DOWNMODULATION
… cells. I validated two candidates, namely CREB-binding protein (CREBBP) and Prolyl 4-Hydroxylase Subunit Beta (P4HB), whose inhibition reduced tumor growth in vivo and increased overall survival of A375-DT but not of A375 parental cells, suggesting a putative point of intervention in …
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Mutational analysis of the human histone chaperone, Nap1, in nucleosome disassembly at the HTLV-1 promoter
… through the interaction with four core histone proteins, H2A, H2B, H3 and H4. These proteins organize the genetic material, however they also make it difficult for the cells to access the information stored within the DNA sequence for processes such as transcription and replication. One of the …
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Breaking the MF curse: the regulatory role of the Methyl farnesoate – MEKRE93 pathway in crustacean molting
… coactivator (Src), and transcription comediators CREB–binding protein (CBP) and C-terminal–binding protein (CtBP). Additionally, genes encoding for the MF synthetic pathway enzymes were also identified in the YO transcriptomes including 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), farnesoic …
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Regulation of human 5-aminolevulinate synthase 2 expression during erythroid differentiation and its role in x-linked sideroblastic anaemia.
… in response to Epo. Transcription factor binding sites located in the 3' end of intron 8 that are critical to intron 8 Epo responsive enhancer activity were also identified. Preliminary studies on the effect of the coactivators CREB binding protein (CBP) and p300 on ALAS2 expression in …
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Electrostatic properties at the interface of p53 Transactivation domain binding
Intrinsically disordered proteins (IDPs) are an abundant class of proteins and protein regions which rapidly change between multiple structures without an equilibrium position. IDPs exist as a series of conformational ensembles of semi-stable conformations that can be adopted based on a hilly …
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Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus
… PEDV infection, and of 16 PEDV nonstructural proteins (nsps), nsp1, nsp3, nsp7, nsp14, nsp15, and nsp16 were found to inhibit the IFN-β and IRF3 promoter activities. The sole accessory protein ORF3 and the envelope (E), membrane (M), and nucleocapsid (N) proteins were also determined to …