Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 416 for “"CRE"”.
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Cre-lox-basierte Inaktivierung des Pbx3-Gens
… Mäusen untersucht. <br>Zur Herstellung eines Cre-lox-basierten „Targeting“-Vektors wurde ein Teil der Genregion des Pbx3-Genes subkloniert und das Exon 3 als Zielsequenz sowie syngene DNA zur homologen Rekombination in den pFlox-Vektor eingefügt. Das linearisierte Rekombinationskonstrukt …
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Gestão do espaço e ambientes de trabalho no CRE
… abordar a forma como os utilizadores da B/CRE se apropriam dos espaços e ambientes de trabalho e a forma como os mesmos são geridos. As leituras feitas, os desafios que foram sendo propostos, despertaram cada vez mais, para a necessidade de fazer uma observação da realidade que vivemos “na …
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Herstellung eines autochthonen, induzierbaren Tumormodells & Entwicklung eines PTD-Cre Induktionssystems
… zeigte ich Tumorentstehung durch Verpaarung mit Cre-rekombinierenden Mäusen. Sechs von neun Nachkommen doppeltransgener Ubiquitin-floxstop-TAgxCre-del. Mäuse entwickelten nach einer Latenzzeit von neun bis zwölf Monaten verschiedene Tumoren (Fibro-, Osteosarkome, Hepatokarzinome und Leukämien). …
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Analysis of Circadian Rhythm Using a Novel SCN-Specific Cre Transgenic Mouse Line
… To test this hypothesis, a novel SCN-specific Cre transgenic mouse line, named NMS-Cre, was developed by inserting a bicistronic Cre expression cassette at the 3’-untranslated region of the Neuromedin S (NMS) gene. By crossing NMS-Cre line to a lox-STOP-lox diphtheria toxin receptor line, …
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Analysis of delinquencies in CRE debt : an approach to understanding risk and pricing
Commercial Real Estate (CRE) debt has been the most staple form of capital for the real estate industry in the US for decades. However, a lot has changed in the CRE debt landscape since the Global Financial Crisis. With growing regulatory constraints for traditional lenders, and massive amounts of …
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Characterization of genetically distinct neuronal subtypes in the lateral habenula using Cre mouse lines
… subregion is marked by non-overlapping genes. Cre mouse lines can be used as a tool to target these genes and thus manipulate these subtypes. This project utilizes fluorescence in situ hybridization (FISH) to genetically characterize the Sst-Cre mouse line to target the HbX subtype and the …
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Measurement of Efficiency of Cre-mediated Recombination between lox loxSites Using a New Vector System
PURPOSE: To measure the Cre-mediated recombination efficiency between 'lox sites' using a new vector system. MATERIAL AND METHODS: A new vector (pFGB) to analyze Cre-mediated recombination efficiency between two lox sites was constructed. The combinations of wild type and mutant lox sites that are …
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Using the Cre-loxP system to randomize target gene expression states and generate diverse phenotypes
… state of multiple genes in S. cerevisiae using Cre-loxP recombination. By inserting promoters flanked by inverted loxP sites in front of a gene of interest we can randomly alter its expression by turning it OFF or ON, or between 4 distinct expression states. We show at least 6 genes can be …
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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters
The central nervous system (CNS) includes the brain and spinal cord, where both possess a blood to brain and a blood to cerebrospinal fluid (CSF) barrier. The blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) regulate the passage of many molecules to maintain and protect these sensitive …
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THE MOLECULAR AND BEHAVIORAL CHARACTERIZATION OF THE MURINE CRE – LOXP SKELETAL MUSCLE SYNTHESIZED BDNF KNOCKOUT MODEL
… has investigated the role of msBDNF by employing Cre/LoxP recombinase technology to selectively delete the BDNF coding region within skeletal muscle of mice. This approach generates animals with either heterozygous or homozygous deletions of msBDNF, as well as BDNF homozygous floxed mice …
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Identification of novel gastric stem cell markers and investigation of Intestinal Stem Cell Cre-mediated Recombination
… Identifying new markers is important for increasing our basic understanding of gastric tissues and studying mechanisms of cancer development. Gastric and intestinal tissues share a common developmental program. Thus, intestinal stem cell genetic drivers were investigated for putative …
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Evaluation of Sex Differences in the Hippocampus and Pituitary of Egr1 conditional knockout mice mediated by Nestin-Cre
… long-term potentiation in the hippocampus and is credited for forming long-term memories. The somatotrophs in the pituitary produce growth hormone and are found to be decreased in Egr1KO mice. These animals are also found to be sterile due to a decrease in LHB, which blocks ovulation. All previous …
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Testing the reliability and selectivity of different bone-cell-specific Cre- expressing mouse models for studying bone cell metabolism
The Cre/loxP system is a tool for targeted recombination of DNA. For applying Cre recombinase-mediated genome modifications, there is a requirement for reliable, high-fidelity, and specific transgenic expression of the Cre recombinase. This study focuses on the reliability of different bone cell …
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Investigating the role of motivation in cross-race facial recognition using a social exclusion paradigm
The cross-race effect (CRE) refers to the finding that participants in face recognition tasks show better memory for same-race faces than cross-race faces. The social cognitive perspective suggests that motivation to encode and remember different faces can affect the CRE. Social exclusion presents …
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Role of glucose transporter 1 during pregnancy
… The first model consisted of a cross between PRP-Cre mice and mice carrying two copies of the Glut1 floxed gene. The second model was a cross between PR-Cre mice and mice carrying two copies of the Glut1 floxed gene. Our studies revealed that the PRP-Cre model did not effectively delete Glut1 …
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Computational approaches for analyzing regulatory regions in the human genome
The cis-regulatory elements (CRE) in the human genome play a critical role in transcriptional regulation. Alterations of the CRE have long been considered as the driving force of the human evolution. Recent studies also suggest that somatic mutations within the CRE can act as driver factors in …
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