Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"CRC risk"”.
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Common genetic variance at the SMAD9 colorectal cancer risk locus influences tumour mutational phenotype
… variance associated with colorectal cancer (CRC) risk can influence the somatic mutational landscapes of CRC. Some Mendelian cancer syndromes, such as Lynch syndrome (LS) and MUTYH associated polyposis, associate with defined mutational landscapes and this association can be functionally …
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Development and validation of risk prediction model for colorectal cancer in patients with gastrointestinal symptoms
BACKGROUND: Colorectal cancer (CRC) is a malignant tumour that grows in the colon and/or rectum. According to the global burden of disease estimate, in 2020, CRC was the third most common cancer and the second leading cause of cancer-related death in the world, with approximately 1.9 million CRC …
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Mitochondrial DNA Copy Number, Insulinemic Potential of Lifestyle, and Colorectal Cancer
Because colorectal cancer (CRC) is the fourth most common cancer and the second leading cause of cancer death in the US, identifying biomarkers that might inform disease prevention and early diagnosis is of great public health importance. Mitochondria are key cytoplasmic organelles containing an …
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Physical activity and Gastrointestinal Cancer: A deeper understanding of risk and underlying mechanisms
… has been identified as an important modifiable risk factor for numerous cancers, with the World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) reporting convincing evidence for a protective role of PA for cancers of the colon, breast and endometrium.<br/><br/>Despite …
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Rare Variant Association Studies In Crohn’S Disease and Colorectal Cancer: Methods and Applications
… of Crohn’s disease and colorectal cancer (CRC) risk. Patients with Crohn’s disease, a condition that causes chronic inflammation of the gastrointestinal tract, are at increased risk of colorectal cancer morbidity and mortality. Genome-wide association studies using single marker approaches …
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Epidemiological evidence that can help to improve timely diagnosis of colorectal cancer in New Zealand.
Incidence rates of colorectal cancer (CRC) in New Zealand (NZ) are among the highest in the world. The long-term survival rates in NZ are poor, which has partially been attributed to late diagnosis. Considering that CRC is a curable disease if diagnosed early, conducting research targeted at the …
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Associations of sex, anthropometric and reproductive factors with clinicopathological and molecular characteristics of colorectal cancer
Colorectal cancer (CRC) is the third most common cancer globally, with approximately 1.2 million new cases every year. The highest incidence rates are seen in developed countries, thereby imposing dietary and lifestyle factors in the etiology of CRC. Accumulating epidemiological evidence suggests …
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From Education to Tumour Characteristics in Colorectal Cancer: An Analysis of the Pathways.
… have been associated with colorectal cancer (CRC) risk. However, their association with prognosis has been less studied. Methods: Path analysis was employed to examine causal pathways from education to environmental (diet, alcohol, smoking, physical activity) and personal factors (screening), …
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Investigating the role of ALDH3B2 and FUT2 as potential risk genes to colorectal cancer through computational analysis and gene expression study of colonic cells, and utilizing colorectal cancer cell lines to explore gene-environment interactions
… known or predicted to be involved in conferring risk to various cancers. Using a systems genetics approach of GWAS and TWAS, this study sought to investigate two identified genes, ALDH3B2 and FUT2, in order to better understand their potential contributions to colorectal cancer (CRC) risk. …
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A qualitative exploration of healthcare workers' perspectives on and experiences with colorectal cancer screening in the Western and Eastern Cape
In South Africa (SA), colorectal cancer (CRC) incidence and mortality is growing at an alarming rate. CRC is often diagnosed at an advanced stage in SA with a noted increase in younger diagnoses and poor outcomes. However, CRC screening and specifically faecal immunochemical testing (FIT) is not …
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Cultural Factors and Concepts of Pollution: Colorectal Cancer and Health Behaviors among Ashkenazi Jewish Women
The colorectal cancer (CRC) incidence in Ashkenazi Jews has been found to be highest of any ethnic group in the world (Feldman, 2001). It is currently unclear how culture and religion influence health behaviors of U.S. Ashkenazi Jews, as well as what other socio-cultural factors influence AJ …
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Inflammatory processes and risk of cancer: epidemiological research.
… negative reactant) are associated with increased risk of subsequent colorectal cancer (CRC) in a prospective cohort - ARIC. After multivariate adjustment, there were statistically significant associations of CRC risk with two individual markers and a summary inflammation Z- score. For the highest …
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Targeting the intestinal stem cell niche through energy and metabolism signaling, for colorectal cancer chemoprevention using aspirin and metformin
Colorectal cancer (CRC) although largely preventable, remains the second most common cause of cancer-related deaths in the United Kingdom. Obesity, type 2 diabetes and physical inactivity are CRC risk factors that alter metabolism. Growing evidence indicates that overnutrition increases ‘stemness’: …
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Development and internal validation of a risk prediction model for high-risk adenomas among average risk colorectal cancer screening participants
Background: High-risk adenomas (HRAs) are precursors to colorectal cancer (CRC), and removing them during colonoscopy can halt progression to CRC. The aim of this study was to develop a risk prediction model for HRAs detected at screening colonoscopy based on readily available patient information. …
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The microbiota and colon cancer risk: cause or consequence?
Background: Colorectal cancer (CRC) has a complex aetiology involving both genetic and environmental factors. Recently, attention has turned to the influence of the gut microbiota upon the development of CRC. The human gut microbiota is altered in CRC and certain microbial patterns are associated …
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Functional Characterization of Bacterial Strains Enriched in Colon Adenomas and Their Impact on Colonic Epithelial Cells
Colorectal cancer (CRC) is one of the most common malignancies worldwide and a leading cause of cancer-related mortality. It arises from the progressive accumulation of genetic and epigenetic alterations in the epithelial cells lining the colon or rectum, often evolving from precancerous lesions …
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Risk Prediction and Value of Polygenic Risk Scores in Colorectal Cancer Screening
Risk prediction models that are based on common genetic variants, known as Polygenic risk Score (PRS), have shown promises to guide personalized screening for colorectal cancer (CRC). Continuous efforts to improve PRS risk prediction are needed for clinical use, and understanding its added value of …
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Beliefs about Diet and Colorectal Cancer Prevention in an Urban Population
… best immediate strategy for colorectal cancer (CRC) prevention, but studies also indicate changes in diet can lower risk of developing CRC. Forty-five percent of CRC cases have been estimated preventable through appropriate diet, physical activity and weight management. Despite evidence on the …
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Studies into the relationship between GPCR43 and BuA-induced effects on colorectal cancer.
Colorectal cancer (CRC) is a major problem in affluent countries worldwide. In Australia it is the second most commonly diagnosed malignancy with approximately 13,000 new cases diagnosed each year. This disease is also the leading cause of cancer related death in Australia with approximately 4,500 …
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Microbial pathways of sulfur metabolism and colorectal cancer risk
Colorectal cancer (CRC) is the third leading cause of cancer, and the second leading cause of cancer death in the United States (US). Recent evidence links consumption of a diet high in animal protein and fat as an environmental risk factor for CRC development, and the intestinal microbiota …