Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"CRAF"”.
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Functional assessment of BRAF and CRAF through Base Editor 3 mutagenesis reveals residues and regions critical for ERK1/2 signalling
… p-ERK1/2 immunofluorescence to screen BRAF and CRAF for mutations that alter RAF kinase activity. The BE3 screen identified a number of mutations in BRAF and CRAF that maintained BRAF or CRAF protein expression, but significantly changed p-ERK1/2 content. This included several known mutations in …
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Structure Based Drug Design of High Affinity Kras Inhibitors
… with nanomolar affinity and completely abolishes CRaf binding in vitro, subsequently leading to a significant reduction in RAS dependent CRaf/ERK activation and son of sevenless (SOS) mediated nucleotide exchange. Moreover, treatment at low micromolar concentrations of compound 11 reduced cell …
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DECIPHERING AND EXPLOITING ANEUPLOIDY IN CANCER
… this pathway, especially those inhibiting CRAF. CRAF activity was also identified as a key factor in the resistance to DNA damage induction, with its inhibition increasing the sensitivity of aneuploid cells to DNA-damaging drugs. Additionally, I observed that aneuploid cells had ramped up …
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Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
… and increased associations between Lyn/c-Raf and cRaf/ERK. This was consistent with increased c-Raf C-terminus phosphorylation that may be regulated by ERK-propelled feedback signaling within a KSR1 scaffold. PP2 and dasatinib had different effects on Lyn activity suggesting that Lyn acts as an …
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Investigating the Role of Oncogenic KRAS G12 Mutations in Cell Signalling
… that has enhanced dimerisation capabilities with CRAF. RAF dimerisation is one mechanism via which RAF inhibitors fail to be effective in treating KRAS mutant cancers. This exemplifies the importance of characterising the identity and role of this BRAF form, as it may have implications on …