Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"CRAC"”.
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The effect of a hamstring contract-relax-agonist-contract intervention on sprint and agility performance in moderately active males
… exist, contract-relax-agonist-contract (CRAC) stretching, a type of proprioceptive neuromuscular facilitation stretching, appears to induce greater flexibility improvements than other forms of stretching. However, the effectiveness of this stretch as a method of enhancing agility and …
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S-Acylation Is A Key Regulator of Orai1/Stim1-Mediated Store-Operated Calcium Entry In T Cells
… release activated Ca<sup>2+</sup> (CRAC) channel which is required for store-operated Ca<sup>2+</sup> entry (SOCE) in T cells and subsequent signaling events leading to T cell activation, proliferation, and differentiation. Plasma membrane (PM)-localized Orai1 is the pore-forming …
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Simultaneous biochemical reaction and separation in a continuous rotating annular chromatograph
… of a continuous rotating annular chromatograph (CRAC) under a combined biochemical reaction and separation duty. Two biochemical reactions have been employed, namely the inversion of sucrose to glucose and fructose in the presence of the enzyme invertase and the saccharification of liquefied …
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Rapid Non-genomic Actions of Cortisol in Fish
… of cortisol with the calcium release-activated (CRAC) channel may be responsible for the rapid increase in [iCa2+] due to cortisol. This increase in [iCa2+] with cortisol played a key role in the translocation of intracellular GR to the plasma membrane. This was evident because inhibition of the …
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The Role Of The Membrane Proximal Region Of The M2 Cytoplasmic Tail In Virus Replication
… recognition/interaction amino consensus: CRAC) motif, previously identified in the membrane proximal region of M2 in some influenza A virus strains, was suggested to play a role in virus replication by mediating incorporation of M2 into budding virus particles. Alteration or completion of …
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The Victim-Patient’s Search for Redress: Evaluating Responses to Patient Safety Incidents in Nigeria
… Accountability, and Compensation, the CRAC objectives. The study identifies three primary response models: Litigation, Ombudsman, and No-Fault Compensation, and evaluates them on the framework of the CRAC objectives. Litigation, while ensuring individual accountability, is hampered by …
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Combined bioreaction and separation in a simulated counter-current chromatographic bioreactor-separator system
… system to a continuous annular chromatograph (CRAC) for the saccharification of modified starch showed that the SCCR-S system required only 34.6-47.3% of the amount of enzyme required by the CRAC. The SCCR-S system was operated in the batch and continuous modes as a bioreactor-separator for the …
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Structure-based development of novel chemical scaffolds as inhibitors of the store-operated calcium entry pathway
… mainly by Orai1, the pore-forming protein of the CRAC (Calcium release-activated calcium) channel, which is activated following store-depletion by aggregated stromal interaction molecule (STIM) proteins that are localised within the ER-membrane and serve as the ER Ca2+ sensor through possession of …
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Identification and Characterisation of New Mouse Models for Hearing Loss
… of the calcium activated calcium entry (CRAC) channel. These two novel mouse models highlight the important role for ENU mutagenesis in disease gene discovery.
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Bleb-driven chemotaxis in Dictyostelium discoideum
… proteins of unknown function – PhdA and CRAC. I conclude that Dictyostelium cells move using a hybrid motor in which hydrostatic pressure-driven bleb formation is as important as F-actin-driven membrane extension, and that cells can change the balance between modes as required. I propose …
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Exosomes act as molecular vehicles contributing to cellular cholesterol efflux
… Aminosäurekonsensussequenzen (CRAC) mutiert sind. Die Verringerung der Flotillin-2-Expression durch siRNA führt zudem zu einer eingeschränkten Sekretion von Cholesterin durch Exosomen. Dieses Ergebnis stellt die Bedeutung von Flotillin-2 für den Cholesterintransport heraus. Der …
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Probing the regulatory mechanisms of the actomyosin system in motile cells
… became round, with fewer or no pseudopods. PH-CRAC translocation to the membrane still occurs, even at low cAMP stimuli, but cell motility (random and directional) was reduced. My data revealed that the decrease in the pool of available PIP2 in the cell is sufficient to impair cell motility, …
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Συσχέτιση του συνδρόμου απνοιών-υποπνοιών στον ύπνο με την έκφραση των διαύλων καλίου στο ανοσοποιητικό σύστημα
… για την εισροή ιόντων Ca²⁺ μέσω των διαύλων CRAC. Επιπροσθέτως, στα Τ-λεμφοκύτταρα ένας από τους διαύλους διαρροής καλίου που εκφράζουν, είναι ο δίαυλος TASK-2, του οποίου η δραστηριότητα ρυθμίζεται από το εξωκυττάριο pH -το οποίο επηρεάζεται άμεσα από τα επίπεδα CO₂- και το οποίο τον καθιστά …