Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 326 for “"CPG"”.
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CPG: Closed Pseudonymous Groups
Internet users generally feel their actions are anonymous, but this is often not the case. Users can be tracked and their actions logged for future analysis, which is not the desire of most users. Software and services exist which offer anonymity on the Internet when used correctly. Anonymity on …
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Immunostimulatory effects and delivery of oligodeoxynucleotides containing CpG motifs (CpG-ODN) in neonatal broiler chickens
Oligodeoxynucleotides containing CpG motifs (CpG-ODN) have been shown to stimulate the innate immune system against a variety of bacterial, viral, and protozoan infections in a variety of vertebrate species. The objectives of this study were to investigate the immunostimulatory effect of CpG-ODN …
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CpG-Oligonukleotid-basierte Immuntherapie von experimentellen Kolontumoren
… Wie bakterielle DNA werden dieser nachempfundene CpG-Oligonukleotide (CpG-ODN) vom Immunsystem als fremd erkannt und dienen antigenpräsentierenden Zellen als Gefahrensignal. In dieser Arbeit wurde an einem murinen Modell des Kolonkarzinoms die therapeutische Wirksamkeit von CpG-ODN getestet und …
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Optimization of CPG budgets in Retailer-led marketing programs
Grocery retailers and Consumer Packaged Goods (CPG) companies have a symbiotic relationship. Retailers need CPGs to supply the products, and CPGs need retailers’ customers to grow their brands. Since shelf space is limited, CPGs offer trade and marketing funds to prominently feature their brands. …
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E-Commerce drop shipping : building a CPG supply chain
… demonstrate our framework by partnering with a CPG manufacturer interested in implementing drop-shipping. Using their data from an existing facility and a selected retailer, we simulate drop shipping orders for a specific set of products during the holiday season that are normally fulfilled by …
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Biological and medical implications of discordance in CpG methylation
… which provides the methylation status of CpGs that are located on the same sequencing read and hence originate from the same DNA molecule. When comparing methylation states of CpGs on the same read, we observed different levels of discordant methylation, defined as molecules where the …
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Regulation of mammalian neuronal circuit development by CPG 15
… plasticity. The extracellular signaling protein CPG15 is one such activity-regulated gene product that promotes the maturation and growth of synapses, dendrites, and axonal arbors during development. Expression of cpg15 mRNA is spatiotemporally correlated with periods of synapse maturation and …
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DNA methylation detection using an engineered methyl-CpG-binding protein
… of such testing to more patients. Methyl-CpG-binding domain (MBD) proteins bind specifically to methylated DNA sequences, and many assays have been developed that use these proteins in methylation profiling of DNA. The wild-type proteins in the MBD family bind specifically to symmetrically …
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LOCOREGIONAL DELIVERY OF UNMETHYLATED CPG-OLIGODEOXYNUCLEOTIDES TO CANCER THERAPY: PRECLINICAL STUDIES
… therefore repeated intraperitoneal injections of CpG-ODN recruiting and activating innate effector cells throughout the abdominal cavity to the tumor site might control tumor cell growth and ascites formation. After a single CpG-ODN treatment, in IGROV-1 ovarian tumor ascites-bearing athymic mice, …
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Identification of Factors Involved In Dna Methylation of Cpg-Island-Promoters
… increased DNA methylation levels at promoter CpG islands (CGI). About one-fourth of empirically defined human promoters are surrounded by or contain clustered repetitive elements. It was previously observed that a sharp transition of methylation occurs between highly methylated repetitive …
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Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides
… (ODN) containing unmethylated CpG motifs are powerful stimulators of innate as well as adaptive immune responses, exerting their activity through the triggering of the endosomally localized TLR9 by a poorly understood mechanism. The immunopotency and broad range of activity of …
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Die Rolle von bakteriellen DNA-Sequenzen (CpG) bei der Immuntherapie von retroviralen Infektionen
… Einsatz von immunstimulativer DNA mit CpG-Motiv (CpG-ODN) bei einer akuten Virusinfektion beschrieben. Als experimentelles Modell wurde das Friend Virus (FV), ein muriner Retroviruskomplex, verwendet. Das FV kann in Mäusen eine tödlich verlaufende Erythroleukämie induzieren. Durch die …
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Design of flexible actuators using electro-active polymers and CPG-based control strategies
… modelling for Central Pattern Generators (CPGs) is presented. The condition for phase synchronization of coupled single chain oscil-lators is derived and various techniques for pattern generation using oscillator network are studied. Finally, octopus based control using Central Pattern …
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Predicting DNA Methylation State of CpG Dinucleotide Using Genome Topological Features and Deep Networks
… to predict the methylation state of DNA CpG dinucleotides using features inferred from three-dimensional genome topology (based on Hi-C) and DNA sequence patterns. We used the experimental data from immortalised myelogenous leukemia (K562) and healthy lymphoblastoid (GM12878) cell lines …
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Incorporation of CpG Oligodeoxynucleotides into α2-Macroglobulin: Development of a Novel Vaccine Adjuvant Delivery Mechanism
… responsible for this activity are unmethylated CpG dinucleotides. Following cellular uptake, CpG-containing oligodeoxynucleotides (CpG ODN) are trafficked to the endosome where they bind Toll-like receptor 9 (TLR9) to initiate a signaling cascade that culminates in the release of numerous …
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Methylated DNA detection using a high-affinity methyl-CpG binding protein and photopolymerization-based amplification
… of the cytosine base, when followed by guanine (CpG) in the promoter region of a protein-coding gene, is an epigenetic modification that has been shown to be involved in gene silencing. While important for regulating many normal, cellular processes, aberrant DNA methylation has been implicated in …
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Exploring induced secondary structure and unmethylated DNA binding domains of methyl CpG binding protein 2 (MeCP2)
Our understanding of Methyl CpG binding protein 2 (MeCP2) structure and function has changed and expanded considerably over the last two decades. Mutations along the entirety of the human MeCP2 gene product lead to a disease state - Rett syndrome. The clinical connection of this protein has …
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