Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"COX2"”.
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Reciprocal communication between cancer cell and tumor microenvironment promotes breast cancer metastasis
… of breast cancer cells. We also found that COX2 was up-regulated in brain metastatic cells and that COX2-induced prostaglandins promote the expression of MMP1 followed by augmenting brain metastasis. Furthermore, we found that COX2 and prostaglandin were able to activate astrocytes to …
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Perfil inmunohistoquímico de los adenocarcinomas nasosinusales de tipo intestinal y lesiones premalignas
… ¿-catenina, EGFR, HER2-neu, p53, p16, ki67, COX2, TNF¿, p65 e iNOS. Estudio de los cambios histológicos observados en tejido sano adyacente al tejido tumoral y de fosa nasal contralateral y estudio IHQ a este nivel. RESULTADOS: El 97% de los pacientes eran hombres con una media de edad de 65 …
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A putative interaction between mitochondrial cytochrome c oxidase subunit II (COX II) to lamin A/C and LAP2α in colon epithelial cells.
… It was found Cytochrome c oxidase subunit II (Cox2) is a putative binding partner to Lamin A/C and LAP2 α. Cox2 is encoded by the mitochondrial genome and imported into complex IV (COX) of the mitochondrial respiratory chain (MRC). The majority of mitochondrial proteins are encoded by nuclear …
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The significance of the EGFR pathway in malignant pleural mesothelioma
IntroductionEGFR, MTOR and COX2 are up regulated in malignant pleural mesothelioma (MPM). In this study we aimed to determine the expression of Lipoxygenase enzymes (LOX), absence of PTEN protein expression and the cytotoxic effect of EGFR, MTOR and COX2 inhibitors in MPM.Materials and …
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Modulation of Inflammation Driven Wound Healing after Glaucoma Surgery
… inflammation-induced ocular fibroblasts, two COX2 Ser516 acetylating molecules were utilized to modify the COX2 enzyme such that it: 1) ceases prostaglandin production, and 2) gains the capacity to produce pro-resolving lipid mediators. When applied to inflammation-induced ocular fibroblasts, …
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Genoprotective effect of aspirin and ibuprofen in human lymphocyte cells. Effect of nano and bulk forms of aspirin and ibuprofen on lymphocytes from breast cancer patients compared with those from healthy females
… was to evaluate this effect on p53, cox1 and cox2 genes. Two hundred fifty ng/ml of ibuprofen (NP and bulk) and 500 ng/ml of aspirin (NP and bulk) were used to treat the lymphocytes. Both aspirin and ibuprofen caused a reduction in DNA damage and micronucleus formation. Aspirin, both forms, …
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Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy
… immediate early genes (IEGs) including CYR61, COX2, BTG2, and ZFP36 were overexpressed in active GO and to a lesser degree in chronic GO, but not in chronic lymphedema. CYR61-responsive genes were also upregulated in active GO. In Study V, associations were found between SNPs in CYR61, BTG2, …
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RNA-binding proteins in yeast mitochondria
… · 1000-fold molar excess of tRNA referring to COX2 leader RNA did not inhibit the RNA-binding of Cit1p and Mdh1p. · Cit1p and Mdh1p bind mitochondrial mRNAs (sense and antisense). The influence of cofactors and substrates on RNA-binding was analysed in order to reveal a possible link between …
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RNA Interference and cyclooxygenase-2 (COX-2) regulation in colon cancer cells
… substituted with the human Cox-2 promoter [pS(COX2)] and with a promoter containing repeated copies of the TCF binding element (TBE) [pS(TBE)]. These promoters were choosen because they are partculary activated in colon cancer cells. COX-2 was effectively silenced in HT-29 and HCA-7 colon …
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ROLE OF SPARC IN DORMANCY OF PROSTATE CANCER IN THE BONE
… prostate cancer patients. We also found that the COX2 inhibitor, NS398, downregulated DNMTs and increased the expression of SPARC leading to tumor growth suppression in the bone in vivo. These findings suggest that SPARC plays a key role in maintaining dormancy of prostate cancer cells in the bone …
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A maternal high fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats
… of cellular senescence, and cyclooxygenase-2 (Cox2), a pro-inflammatory marker, was significantly higher in the HF/C offspring group than in the C/C offspring group. Western blot analysis shows that cyclin D1 and phosphorylated retinoblastoma (p-Rb) protein were significantly lower in HF/C …
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Maternal Exposure to Prostaglandin E2 Affects Hippocampal Synaptic Plasticity in Mice Offspring -A Link to Autism Spectrum Disorder
… of the PGE2 producing enzyme Cyclooxygenase-2 (COX2) results in sex-specific abnormal dendritic morphology within the cerebellum and the hippocampus as well as ASD-like behaviors including motor deficits and anxiety in mice offspring. In this study, I investigated sex-dependent effects of …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
… of axon growth cones, indicating that inhibiting COX2 with the nanoemulsion therapy promotes axon regeneration. These observations will be discussed in the context of other studies on additional infiltrating inflammatory cells and changes in gene expression that are evident during nerve injury and …
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LncRNA discovery in the Listeria monocytogenes infection model
… handful of studies have identified lncRNAs linc-Cox2, Lethe, PACER and THRIL as central players in host cell innate immune response against microbial infection. These discoveries and the vast numbers of uncharacterized lncRNAs identified by high-throughput nextgeneration transcriptome sequencing …
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Nuclear Receptors in Lung Cancer
… correlated to the expression of cylooxygenase 2 (COX2), which is shown to be decreased with PPARγ ligand treatment. In the transgenic model, I demonstrated that expression of a subgroup of NRs in wild type mice becomes altered in histologically normal tissues that harbor the K-ras mutation, and …
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Gangliosides와 oxidized low density lipoprotein (oxLDL) 에 의한 신경교세포의 활성조절 및 그 기전에 대한 연구
… Inhibits LPS-induced Expression of iNOS and COX2 in Primary Microglia Cultured from Rat Brain 38 2. OxLDL Suppresses the Expression and Release of Inflammatory Mediators in an Oxidation-dependent Manner 38 3. Inhibitory Effects of OxLDL are Mediated by Interference with LPS-induced NFκB …
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Predictive Computational Modelling of the c-myc Gene Regulatory Network for Combinatorial Treatments of Breast Cancer
… affect one sub-clone, but the addition of COX2 inhibition improves effectiveness across the tumour as a whole. In this thesis, I show how a computational network model can predict treatments in breast cancer, and assess the effects on different clones of different treatment combinations. …
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IL-1 activation of NF-kB contributes to perinatal hypoxia/ischemia induced cell death
… of p65. Protein expression levels of iNOS and COX2, known to be transcriptionally regulated by NF-kB, also increased at 24h post-HI. All these changes were reversed by IL-1Ra blockade of IL-1, consistent with IL-1 triggering of inflammatory apoptotic outcomes via NF-kB transcriptional …
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Charakterisierung der Untereinheit e der mitochondrialen F1FO-ATP Synthase aus Saccharomyces cerevisiae
… Sue der F1FO-ATP Synthase und der Unter-einheit Cox2 der Cytochrom c-Oxidase konnte eine enge räumliche Bezie-hung nachgewiesen werden. Diese ist von der Funktionalität der F1FO-ATP Synthase abhängig. Anhand der Ergebnisse der vorliegenden Arbeit konnte somit folgende Erklä-rung für die Funktion …
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Insulin resistance in cancer cachexia and metabolic syndrome
… induction provoked by PGE2 in IL-1β, mPGES1 and COX2, and attenuated the inhibition induced by PGE2 in CCL2 and TNF-α gene expression contributing to an enhanced inflammatory response by both mechanisms. Supernatants of insulin-treated U937 macrophages reduced the insulin-dependent induction of …
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