Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"COX-2 inhibition"”.
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
<p>Celecoxib nanoemulsion (CXB-NE) has been developed as a macrophage targeted analgesics by Dr. Janjic and her team at Duquesne University, (Janjic et al, 2018; Liu et al, 2020; Saleem et al, 2019b; Vasudeva et al, 2014). The CXB-NE nanoemulsion carrying a Nonsteroidal Anti-inflammatory (NSAID) …
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The Immunosuppressive Function of VEGF Signaling in the Tumor Microenvironment
… effective companion therapies. Cyclooxygenase-2 (COX-2) inhibition has been shown to promote tumor cell differentiation and improve standard therapy response in pancreatic cancer. Here, I evaluate the efficacy of COX-2 inhibition and VEGF blockade in preclinical models of pancreatic cancer and …
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The Efficacy Of Prostaglandin Synthase Inhibition On Attenuating Pressure Overload Induced Cardiac Remodeling
… and functional parameters. Cyclooxygenase-2 (COX-2) inhibition with Nimesulide significantly attenuated the structural and functional changes associated with LV remodeling due to pressure overload. Prevention treatment with Nimesulide shothat the beneficial effects seen with acute treatment …
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Therapeutic Modalities Targeting Neuroinflammation After Neonatal Hypoxia-Ischemia
… outcomes. Herein, we tested the hypothesis that COX-2 mediates mechanisms of brain injury and that G-CSF exerts structural and functional protection after neonatal HI.</p> <p>To mimic the clinical features of HI brain injury, neonatal rat pups were subjected to unilateral carotid artery ligation …
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Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… therapy and diagnosis. Cyclooxygenase-2 (COX-2), an enzyme involved in the biosynthesis of a lipid inflammatory mediator, prostaglandin E2 (PGE2), is over expressed in macrophages infiltrating the pathological site. Inhibition of PGE2 leads to reduced inflammation, pain and macrophage …
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Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… therapy and diagnosis. Cyclooxygenase-2 (COX-2), an enzyme involved in the biosynthesis of a lipid inflammatory mediator, prostaglandin E2 (PGE2), is over expressed in macrophages infiltrating the pathological site. Inhibition of PGE2 leads to reduced inflammation, pain and macrophage …
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From bench to bedside : elucidating vestibular schwannoma pathobiology to devise effective pharmacotherapies
… kappa B (NF-KB) and enzyme cyclooxygenase 2 (COX- 2) were aberrantly active in VS. NF-KB inhibition, achieved through siRNA, an experimental agent BAYl 1-7082 or a clinically relevant drug curcumin, was cytotoxic against primary VS cells and HEI-193 VS cell line. COX-2 inhibition, achieved …
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Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2
… Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2 William T. E. Briggs The cyclooxygenase (COX)-2 inhibitors, or “coxibs,” are excellent anti-inflammatory agents, but their reputation has been tarnished by the adverse cardiovascular (CV) events, including heart …
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Ethnopharmacology of medicinal plants traditionally used in the Greater Mpigi region, Uganda
… experiments, e.g., monitoring of quorum sensing inhibition and direct protein output (δ-toxin) in Staphylococcus aureus; e) antiinflammatory investigations (e.g., cyclooxygenase-2 inhibition); f) antimalarial studies against chloroquine-resistant Plasmodium falciparum K1; g) cytotoxicity …
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Anti-asthmatic and anti-cough activities of the essential oil Of Eucalyptus Grandis W. Hill Ex Maiden
… oil. Cytosolic LDH was released and efflux pump inhibition activity was monitored to determine the apparent bactericidal mechanism of the essential oils. Antioxidant activity (free radical scavenging of nitric oxide, hydroxyl radical, superoxide anion, and also the sulfhydryl, NADH as well as the …