Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 37 for “"COX-1"”.
-
Stimulated Emission Depletion (STED) Microscopy and Pacific Orange Dye Optimization For H9C2 Cox-1 Imaging Via Indirect Immunocytochemistry
… and stained via indirect immunofluorescence: COX-1 proteins of the mitochondrial inner-membranes were targeted by primary mouse, anti-COX-1 IgG antibodies, which in turn were targeted by Pacific Orange conjugated secondary F(ab')2 fragment goat, anti-mouse IgG antibodies. Cell samples were …
-
Concomitant Suppression Of Both Cox-1 And Cox-2 Is Not Sufficient To Cause Gastroenteropathy Associated With Chronic Nsaid Use
… simultaneously inhibiting both cyclooxygenases (COX) -1 and -2 to suppress prostaglandin synthesis. Operating under this assumption, I had developed a novel mouse model of inducible COX-1 + COX-2 deletion to complement our lab’s chronic NSAID exposure model. These COX double-knockout mice …
-
The Involvement of the Cyclooxygenase Enzymes in the Gallus Domesticus Model of Ovarian Cancer
… was to determine if the cyclooxygenase (COX) enzymes are involved in ovarian carcinogenesis in the hen as a model for the human disease. The expression patterns of COX-1 and -2 mRNA and protein in normal hen ovaries and hen ovarian tumors were determined. COX-1 mRNA expression was …
-
Non-steriodal anti-inflammatory drug-mediated regulation of COX-2 and EP3 receptor expression in the M-1 murine cortical collecting duct cell line.
… isoform specific antibodies, we have localized COX-1 and -2 immunoreactivity to all cell types of the murine M-1 CCD cell line. By, immunohistochemistry, both COX-1 and COX-2 were localized to the intercalated cells of the collecting duct on paraffin embedded mouse kidney sections. When COX …
-
The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
… of PGE₂ synthesis through the cycoloxygenase-2 (COX-2) pathway at an early stage of muscle recovery from damage attenuated skeletal muscle regeneration. However, the exact mechanisms by which PGE₂ regulates skeletal muscle development and regeneration are elusive. In this project, the central …
-
Elucidating the Interplay Between Lipids and Membrane Proteins Using Multiscale Computer Simulations
… of AMPA receptors and cyclooxygenases (mainly COX-1), showing that they both form specific interactions with lipids, but do so in a quite different fashion. AMPA receptors interact specifically with diacylglycerol lipids, whereas COX-1 enzymes do so indiscriminately with glycerophospholipids, …
-
Neuroglial Mechanisms Involved In The Anti-Inflammatory Effect Of Acetate Supplementation
… tumor necrosis factor (TNF)-α, cyclooxygenase (Cox)-1 and 2 protein levels, and NF-κB p65 protein level and phosphorylation at serine 468. Further, acetate treatment increased IL-4 and transforming growth factor (TGF)-β1 expression, and NF-κB p65 acetylation at lysine 310. Conversely, acetate …
-
PROSTAGLANDIN E2 PATHWAY AS A TARGET TO PREVENT AND TREAT OVARIAN CANCER IN LAYING HENS
… products of 2 isoforms of cyclooxygenase (COX) enzymes: COX-1 and COX-2. Although both COX isoforms have similar structure and function, they are encoded by different genes and show distinct expression patterns. COX-1 is expressed in most cells and tissues and remains constant under most …
-
The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)
… production. Healthy canine kidneys express both COX-1 and COX-2, although basal COX-2 expression in dogs is significantly higher than in other species. Nonsteroidal anti-inflammatory drugs that spare COX-1 have exhibited less gastrointestinal toxicity, but no NSAID has been proven safe for the …
-
Expression and Function of a Putative Cox-Like Gene in D. melanogaster
<p>Cyclooxygenases (COX) are the enzymes that catalyze the conversion of arachidonic acid into prostaglandins. In mammals, isoform COX-1 is constitutively expressed, whereas the isoform COX-2 gene expression is induced, primarily at sites of inflammation. While eicosanoids play a major role in …
-
Identification of host cellular factors that regulate human norovirus replication
… norovirus replication requires the activity of COX-1 so that the inhibition of the enzyme with a small molecule inhibitor (SC-560) reduced virus replication. Prostaglandin E2 supplementation abrogated the effect of SC560 on HuNoV replication. We also observed that a prolonged treatment of the …
-
Impact des microvésicules de plaquettes sur l'expression de produits inflammatoires des monocytes et macrophages THP-1
… l’abondance des protéines cyclooxygénase (COX)-1 (encodée par le gène PTGS1) et TBXA A1 augmenta dans les cellules THO-1 de façon significative et proportionnelle à la dose de PMVs. La sécrétion de 12-HHTrE, produit par l’activité des deux enzymes transférées sur l’acide arachidonique (AA), …
-
Exposição à Hiperglicemia Materna Induz Disfunção Endotelial Em Artérias de Resistência da Prole Adulta. Papel das Prostaglandinas Derivadas da Cox-2.
… e se a ativação das vias das ciclooxigenases (COX) está envolvida neste efeito. O diabetes materno foi induzido por estreptozotocina no dia 7º de gestação em ratas Wistar. Estudos de reatividade vascular foram realizados para analisar o relaxamento à acetilcolina (ACh) e a contração à …
-
The Study of Serial Histochemical Changes in Laser-related Post-inflammatory Hyperpigmentation
… stimulating hormone (α-MSH), cyclooxygenase-1 (COX-1), COX-2, vascular endothelial growth factor and stem cell factor (SCF) were also investigated. The expressions of hsp-70 and TNF-α were decreased after the irradiation and recovered within 28 days. The expressions of VEGF were increased …
-
Measurement of lipid peroxidation in biology models using gas-chromatography-aass spectrometry
… of lipid peroxidation are formed long before the COX-1 enzyme is activated.</p>
-
Production of prostaglandin E2 and thromboxane A2 by rat liver macrophages and involvement of nitric oxide and cytokines in mediator pathways under inflammatory conditions
… LPS effect, localization in membrane fraction. COX-1: is expressed in resting Kupffer cells; COX-1 expression is not influenced by LPS and dexamethasone. The COX-1 inhibitor SC560 suppresses the LPS-induced production of PGE2 and TxA2 (8h and 24h), localization predominantly in membrane …
-
Implication des prostaglandines dans l'accumulation d'OPG dans le surnageant d'ostéoblastes et dans un modèle d'ostéoclastogénèse
… changé suite au traitement avec un inhibiteur de COX-1 (valeroyl salicylate), un inhibiteur de COX-2 (NS 398), ni avec des inhibiteurs non spécifiques des COX (diclofenac, naproxen, indomethacine). Dans la présente étude, la PGE[indice inférieur 2] ainsi que la PGD[indice inférieur 2] ajoutées de …
-
Influence of the reducing agent triphenylphosphine on cyclooxygenase-1 metabolism of arachidonic acid
<p>Cyclooxygenase (COX) metabolizes the polyunsaturated fatty acid arachidonic acid (AA) to PGG2, a cyclic endoperoxide that also contains a hydroperoxide, which is subsequently reduced to an alcohol in the enzyme to yield PGH2. Reactions catalyzed by COX-1 are significantly influenced by lipid …
-
Effekte der Stimmungsstabilisatoren Lithium, Valproat und Lamotrigin auf die Cyclooxygenase-2-Synthese in SK-N-SH Neuroblastomzellen
… (VPA) im Rattenhirn sowohl die Cyclooxygenase (COX)-2-Synthese als auch die Prostaglandin E2 (PGE2)-Ausschüttung reduzieren. Aufbauend auf dieser Beobachtung sollten in dieser Arbeit die Effekte der Stimmungsstabilisatoren Lithium, Lamotrigin und Valproat auf die Interleukin-1beta induzierte …
-
Effects of chronic exposure to ibuprofen and naproxen on Florida flagfish (Jordanella floridae) over one complete life-cycle
… through the inhibition of cyclooxygenase (COX), an enzyme present in two isoforms in the body; the constitutively expressed COX-1 and the inducible COX-2. Traditional NSAIDs like ibuprofen inhibit both isoforms with little selectivity while newer variants such as naproxen preferentially …
Page 1 of 2