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Showing 1 to 10 of 10 for “"COP9 Signalosome"”.
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Role of the COP9 Signalosome In Defense Responses In tomato
<p>The COP9 Signalosome (CSN) is an evolutionarily conserved multi-protein complex that regulates proteasome-mediated proteolysis. While the CSN has been shown to function in various growth and developmental processes, the involvement of the CSN in the regulation of defense responses is largely …
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Amino Acid Biosynthesis and the COP9 Signalosome in Aspergillus nidulans
… unter entsprechenden Mangelbedingungen. Das COP9 Signalosom ist Teil eines regulatorischen Netzwerkes welches essentiell für Entwicklungsvorgänge in höheren Eukaryonten ist. Komponenten aus beiden Systemen wurden aus A. nidulans isoliert und ihr Einfluss auf physiologische und metabolische …
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COP9 signalosome subunit knockdown in K562 provides novel insight into the function and potential regulation of the CSN
… (deneddylation) is mediated by the eight subunit COP9 signalosome (CSN; CSN1-8). Cullin deneddylation by the CSN has been demonstrated to prevent the autocatalytic degradation of the substrate recognition subunit (SRS) of CRLs. The CSN has also been shown to associate with deubiquitinase and …
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Investigation of the effect of a probiotic-supplemented diet on the haemocyte proteome of the abalone Haliotis midae
… probiotic-supplemented diet were identified as COP9 signalosome subunit 4, phosphorylase, T-complex protein 1 subunit gamma, V-type proton ATPase subunit B, Rab 1 and Ra-related protein Rab 1A. Differential expression of COP9 signalosome subunit 4 (up-regulated) and Ras-related protein Rab 1A …
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Cop 9 Signalosome Subunit 6 Stabilizes Cop1, A Novel E3 Ubiquitin Ligase For 14-3-3Σ
… degradation. We show for the first time that COP9 signalosome subunit 6 (CSN6) associates with COP1 and is involved in 14-3-3σ ubiquitin-mediated degradation. Mechanistic studies show that CSN6 expression leads to stabilization of COP1 through reducing COP1 self-ubiquitination and decelerating …
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The Novel Upstream Regulator of Fbxw7
… 1 (COP1), AKT and CSN6 (i.e. the COP9 signalosome 6).</p> <p>COP1 is an E3 ubiquitin ligase targeting important substrates such as, p53, 14-3-3-σ, and c-Jun. I found that COP1 binds to FBXW7 at the binding motif at V200 and P201. Interestingly, binding between COP1 and FBXW7 was …
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Characterization of Factors Controlling Germline Stem Cell Maintenance in Drosophila Melanogaster
… hypomorphic bam background. Components from the COP9 signalosome complex (CSN) and the SCF E3 ubiquitin ligase complex were identified as dominant Suppressors of bam, Su(bam). Since both the CSN and SCF complexes are involved in protein degradation, the suppression of the bam phenotype suggests …
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Identification of Novel Regulators in Hematopoiesis: Roles for Gfer in Hematopoietic Stem Cell Proliferation and CaMKK2 in the Restriction of Granulopoiesis
… binding with its inhibitor, the COP9 signalosome subunit jun activation-domain binding protein 1 (Jab1), that would subsequently lead to its ubiquitination, and determined that depletion of Gfer resulted in enhanced binding of p27<sup>kip1</sup> to Jab1. Conversely, …
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
… alter FLIP'S stability. CSN5, a component of the COP9 signalosome was identified from a DUB screen for FLIPl, but had also appeared on a yeast-2- hyrbid screen for FLIPl from our laboratory. It was found to interact with FLIP in a ubiquitination-dependent manner and when silenced dramatically …
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CsnA Dependent Development and Regulation of Amino Acid Biosynthesis of the Filamentous Ascomycete <i>Aspergillus nidulans</i>
… ist. Diese Arbeit konzentriert sich auf das COP9 Signalosom, einen essentiellen, eukaryontischen Entwicklungsregulator und die generelle Kontrolle der Aminosäurebiosynthese (gc). Die generelle Kontrolle regelt die zelluläre Antwort auf Aminosäuremangel. Beide Netzwerke sind von der Bäckerhefe …