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Showing 1 to 8 of 8 for “"COP1"”.
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14-3-3Sigma Negatively Regulates The Stability and Subcellular Localization of Cop1
Mammalian constitutive photomorphogenic 1 (COP1), a p53 E3 ubiquitin ligase, is a key negative regulator for p53. DNA damage leads to the translocation of COP1 to the cytoplasm, but the underlying mechanism remains unknown. We discovered that 14-3-3σ controlled COP1 subcellular localization and …
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Cop 9 Signalosome Subunit 6 Stabilizes Cop1, A Novel E3 Ubiquitin Ligase For 14-3-3Σ
… Mammalian Constitutive Photomorphogenic 1 (COP1) as a novel E3 ubiquitin ligase for targeting 14-3-3σ through proteasome degradation. We show for the first time that COP9 signalosome subunit 6 (CSN6) associates with COP1 and is involved in 14-3-3σ ubiquitin-mediated degradation. Mechanistic …
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The Novel Upstream Regulator of Fbxw7
… which involves constitutive photomorphogenic 1 (COP1), AKT and CSN6 (i.e. the COP9 signalosome 6).</p> <p>COP1 is an E3 ubiquitin ligase targeting important substrates such as, p53, 14-3-3-σ, and c-Jun. I found that COP1 binds to FBXW7 at the binding motif at V200 and P201. Interestingly, binding …
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UV-resistance locus 8 and UV-B specific signaling in Arabidopsis thaliana
… DNA damage signals as well as UVR8, HY5, HYH and COP1; one gene was expressed in a COP1-dependent but UVR8 independent manner. It therefore appears that at least four classes of genes are induced by UV-B; low fluence UVR8/HY5/HYH independent COP1 dependent, low fluence UVR8/HY5/HYH/COP1 dependent, …
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The Roles of the Drosophila Protein Tribbles in Oogenesis and Insulin Signaling Pathway
… kinase kinase MEK1 and E3 ubiquitin ligase COP1 binding motifs, the latter required for the degradation of target proteins via proteasome. During oogenesis, Trbl controls border cell (BC) cluster migration by mediating degradation of C/EBP transcription factor Slbo. I first investigated …
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Elucidating the role of TM9SF2 in membrane trafficking
… by vesicles formed by coat protein complex 1 (COP1), via cargo adaptors such as Golgi phosphoprotein 3 (GOLPH3), for recycling to earlier parts of the Golgi. Published genome-wide CRISPR-Cas9 knockout screens interrogating glycosylation pathways have implicated the highly conserved …
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Identification of motifs in the tribbles kinase required for substrate interactions
… this kinase motif, Trbl has C-terminal MEK1 and COP1 binding sites, raising the possibility that Trbl is a docking kinase with motifs that impart specificity to bind and degrade multiple pathway components. To test the ability of Trbl to directly bind Slbo while avoiding the problem of Slbo …
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The effect of UV-B radiation on flavonoid accumulation and gene expression in Marchantia polymorpha
… in M. polymorpha contains the main regulators COP1, HY5 and RUP1 and act to enhance flavonoid biosynthetic genes such as CHS, CHI and FNS. RNA-seq and nCounter analysis also revealed differential expression in stress related genes that may offer protection independently of the UVR8 pathway and …