Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"COMT"”.
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COMT Genotype, Schizophrenia, and Dopamine Transmission
Catechol-o-methyltransferase (COMT) catabolism is the primary mechanism for dopamine signal deactivation in the dorsolateral prefrontal cortex, an area of the brain associated with working memory. Working memory deficits are found in persons with schizophrenia and their unaffected siblings. A …
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Polymorphisms in the COMT and MAOA genes and their consequences for clinical, neuropsychological and neuroimaging dimensions in a population at high risk of schizophrenia
… important. Dopamine is degraded by two enzymes COMT and MAOA. Thus mutations in the genes controlling the effectiveness of these enzymes may render subjects with a hyperdopaminergic state. This thesis will concentrate on two specific Single Nucleotide Polymorphisms in the MAOA and COMT genes and …
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The relationship between genes associated with the pain pathways and the development of chronic shoulder pain and disability in South African breast cancer survivors
… and (III) Catechol-O-Methyl Transferase Gene (COMT); (rs6269 A>G; rs4633 C>T; rs4818 C>G; rs4680 G>A) and the prevalence of chronic pain and disability. iii. Evaluate the gene-gene interaction and association between prioritised SNPs for ABCB1 (rs1045642 G>A; rs1128503 G>A), OPRM1 (rs1799971 …
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The aetiology of pain in chronic midportion Achilles tendinopathy
… a candidate gene approach. Candidate genes: COMT rs4818 (C/G), COMT rs4633 (C/T), TAC1rs2072100 (C/T), TACR1 rs3771829 (C/G) and SCN9A rs6746030 (G/A) were selected based on the biological function of their encoded proteins within the pain pathways. The objectives of the specific chapters …
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Toxicity of TCDD in the mouse antral follicle
… woman. The enzyme catechol-o-methyltransferase (COMT) is regulated by E2 and is an important enzyme for inactivating the catecholestrogens. Thus, we hypothesized that TCDD exposure affects the levels of COMT. TCDD exposure reduced COMT protein levels, while there was no change in transcript …
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Looking Through the Lens of Individual Differences: Relationships Between Personality, Cognitive Control, Language Processing, and Genes
… variation in catechol-O-methyltransferase (COMT), a gene that regulates the catabolism of dopamine in prefrontal cortex, is related to individuals’ ability to resolve lexical and syntactic conflict. The results of this study demonstrated that individual differences in the ability to resolve …
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Estrogen sulfotransferase (sult1e1) expression and function in mcf10a-series breast epithelial cells: role as a modifier of breast carcinogenesis and regulation by proliferation state
… 2), CYP1B1, and catechol-O-methyltransferase (COMT) in an MCF10A-derived lineage cell culture model for basal-like human breast cancer progression and in ERα-positive luminal MCF7 breast cancer cells. Low levels of ERα and ERβ mRNA were present in MCF10A-derived cell lines. SULT1E1 mRNA was …
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Gene discovery: Polymorphism association with obsessive-compulsive disorder and proteome analysis of Artemisia annua.
… (DRD2) gene; Catechol-O-Methyl Transferase (COMT) NlaIII high/low activity polymorphism; 5-HT2A 1438 A/G polymorphism; 5-HT1Dβ G861C polymorphism and the 5-HTTLPR 44-bp deletioninsertion. There was a higher frequency of the DRD2 A2 allele (p = 0.020) and a higher frequency of the …
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The impact of serotonergic and dopaminergic genetic variation on endophenotypes of emotional processing
… the enzyme catechol-O-methyltransferase (COMT) and the dopamine transporter (DAT), respectively, which both terminate dopamine signalling and are thus important regulators of dopaminergic neurotransmission, on the startle reflex in older adults. COMT met/met homozygotes showed the …
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Genetic, agronomic and compositional characterization of brown midrib sweet sorghum lignocellulosic biomass for ethanol production
… caffeic acid-<em>O</em>-methyltransferase (<em>COMT</em>) gene resulting in reduced lignin content. A useful InDel marker for the mutant allele of <em>COMT</em> was identified for this population. Fiber detergent analysis (FDA) was performed to estimate the amount of hemicellulose, cellulose and …
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Two Sides of The Same Coin in The Levodopa Treatment of Parkinson's Disease
… Hcy export from astrocytes was induced by the COMT substrates L-dopa. So, I have examined the role of NMDA receptor-mediated activation of the extracellular signal-regulated kinase-mitogen-activated protein (ERK-MAP) kinase pathway in Hcy - dependent neurotoxicity on NPCs in isolated from the …
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Cortisol in Middle Childhood: Associations with Genetic Polymorphisms and Early Environmental Risk
… prior work involving three polymorphisms (COMT Val158Met, MAOA-LPR, and 5-HTTLPR) has yielded well publicized but inconsistently replicated associations with mental health. Part of this inconsistency may be due to the limited exploration of mechanistic explanations for how these …
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The Relationship between methylation and genes associated with opioid response in humans.
… Genetic variations within ABCB1/MDR1, COMT, CYP2B6, CYP2D6 and OPRM1 genes were also investigated. Tissue opioid concentrations were determined by HPLCMS/ MS and GC-MS/MS. DNA methylation was influenced by chronic opioid exposure and / or the lifestyle associated with opioid dependency, …
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The interactive effects of genetics and cardiorespiratory fitness level on cognitive performance in healthy older adults
… to aging. The Catechol-O-Methyltransferase (COMT) and Dopmaine Beta Hydroxylase (DBH) genes were chosen because their protein products influence levels of dopamine within the brain. Further, each gene has two common functional single nucleotide polymorphisms which effect the functionality of …
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Neuronale Korrelate von Delay Discounting
… und einer Genotypisierung für den COMT Val 158 Met Polymorphismus, den DRD2 Taq 1 A Polymorphismus und den DAT 1 Polymorphismus ist das Delay Discounting Paradigma an insgesamt 90 Probanden im Magnetresonanztomographen eingesetzt worden, so dass 84 auswertbare Datensätze gewonnen …
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Dopamin und kognitive Handlungssteuerung: Flexibilität und Stabilität in einem Set-Shifting Paradigma
… spontane Lidschlagrate (EBR), die Polymorphismen COMT Val-158-Met und DRD4 Exon III sowie das Geschlecht eingesetzt. In der dritten Studie sollte eine Dopaminausschüttung experimentell durch die Darbietung von Signalen einer potenziellen Belohnung (Geldgewinn) stimuliert werden. Hierdurch sollten …
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Molekulargenetische Aspekte dopaminerger Modulation der Responsivität gegenüber Neuheit
… oder indirekt die Dopamin-Funktion beeinflussen (COMT, 5-HTTLPR). In Studie II konnten die Ergebnisse einer vorhergehenden Arbeit repliziert werden, die einen Effekt des DRD4 Exon III 7-Repeat-Allels nur für bestimmte Genotyp-Gruppierungen der anderen beiden Polymorphismen zeigte. Zudem kann …
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Genetic factors associated with neuropathic pain
… associated with NP, and that SNPs in neither COMT nor OPRM1 were associated with NP. he GWAS using dispensed medication records identified a novel genome-wide significant NP susceptibility locus near PRL, and replicated this in UKBB. The largest meta-analysis of the discovery GWAS of NP using …
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Dopaminergic Genetic Contributions to Obesity in Kidney Transplant Recipients
… (VNTR), catechol-o-methyltransferase gene (COMT) SNPs rs4680 and rs4818, monoamine oxidase A gene (MAOA) VNTR, monoamine oxidase B gene (MAOB) SNP rs1799836, and dopamine active transporter gene (SLC6A3/DAT1) VNTR. Genotypes were analyzed using dose dependent and risk allele approaches, and …
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