Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"COL3A1"”.
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Vascular Injury In Col3A1+/- Mice Model of Vascular Ehler-Danlos Syndrome
… carry a glycine mutation located in their <em>COL3A1 </em>gene, which encodes the propeptide of type III collagen. Mutations in glycine residues lead to a disruption in the assembly and maturation of type III collagen. The goal and significance of the current study was to investigate the …
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Delayed Thrombus Resolution and Fibroproliferative Vascular Wound Healing From Deficiency of Type Iii Collagen: A Paradoxical Mechanism For Tissue Fragility
… of connective tissue caused by mutations in <em>COL3A1</em>, conferring a tissue deficiency of type III collagen. Cutaneous wounds heal poorly in these patients, and they are susceptible to spontaneous and catastrophic rupture of expansible hollow organs like the gut, uterus, and medium-sized to …
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Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes
… other collagen fibril encoding genes, such as COL3A1, COL6A1 and COL12A1, will also be associated with these and/or other musculoskeletal soft tissue injuries and exercise-related phenotypes. The COL5A1 rs12722 and COL12A1 rs970547 gene variants have been previously associated with risk of ACL …
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Extracellular matrix gene sequence variant analyses and Achilles tendinopathy
… Candidate genes (COMP, THBS2, COL27A1, TNC, COL3A1, COL5A2 and COL5A3) were selected based on their chromosomal location and/or the biological function of their encoded proteins within the extracellular matrix (ECM) of the tendon.
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Tissue inhibitor of metalloproteinase-1 contributes to ovulatory dysfunction in a rat model of endometriosis
… genes associated with extracellular matrix (Fn1, Col3a1) and angiogenesis (Vegf). Treatments of rTIMP1 caused downregulation of apoptosis genes (Casp3). Ala-TIMP1 and rTIMP1 co-immunoprecipitated TIMP1 with GRP78 and GSTA3 which are both involved in protein protection. Ala-TIMP1 complexed more to …
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Primäre Leberzellen und ihr Beitrag zur sinusoidalen extrazellulären Matrix - Eine Genexpressionsstudie
… werden. Gene fibrillärer Kollagene, insbesondere COL3A1, deren Produkte als wachsende Hauptmatrixkomponenten des fibrotischen Sinusoids etabliert sind, wurden auch in den untersuchten fibrotischen Proben signifikant hochreguliert. Ähnliche Tendenzen zeigten sich in durch Chemotherapie geschädigten …
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Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… barrier integrity. miR-133a-5p suppressed COL3A1 and TSP-1 expression, limiting vascular permeability and leukocyte recruitment. Furthermore, miR-133a-3p promoted ADAMTS-1 expression under TNF-α stimulation, supporting ECM remodelling, while miR-133a-3p also induced ICAM-1 expression in …
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DELINEATING REGULATORY PATHWAYS OF NOVEL CANCER STEM CELL MARKER, DCLK1-S, FOR TARGETING COLON CANCER STEM CELLS
… results in NFATC2 binding and activation of the COL3A1 promoter which enhances the invasive potential of colon cancer cells. The 5’(α)-promoter is differentially methylated in normal human colons vs. human colorectal cancers, however the methylation status of the IntronV(β)-promoter does not …
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A histopathological and genomics study of the mutated human FAM111B gene related POIKTMP disease
… markers: MMP3, MMP13, PDGFA, ITGB-1, THBS-2, COL3A1, TGFβ3, and CCN2 in the patient lungs and skin tissues, which were validated by qRT-PCR. Furthermore, these genes with FAM111B form a gene-list that was used in interrogating various gene-set libraries in the gene-set enrichment analysis. …
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A histopathological and genomics study of the mutated human FAM111B gene related POIKTMP disease
… markers: MMP3, MMP13, PDGFA, ITGB-1, THBS-2, COL3A1, TGFβ3, and CCN2 in the patient lungs and skin tissues, which were validated by qRT-PCR. Furthermore, these genes with FAM111B form a gene-list that was used in interrogating various gene-set libraries in the gene-set enrichment analysis. …
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A MECHANISM FOR CORTICAL BONE STEM CELL-DERIVED EXOSOMES’ THERAPEUTIC EFFECT ON POST-MYOCARDIAL INFARCTION REPERFUSION INJURY AND CARDIAC REMODELING
… metalloproteinase 9 (MMP9) and Collagen 3A1 (Col3A1), as evidenced by qPCR analysis. Next, to examine if exosomes decrease fibrotic activation, adult rat ventricular fibroblasts (ARVFs) and adult human cardiac fibroblasts (NHCFs) were treated with TGFβ to activate fibrotic signaling before …
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Overcoming wound healing complications following radiotherapy in human breast dermal fibroblasts, through the influence of preadipocytes from the stromal vascular fraction
… inhibitor array) and gene expression of COL1A1, COL3A1, MMP1, MMP2, TIMP1 and PPAR-γ mRNA (qPCR). Cells from the stromal vascular fraction (SVF) were cultured and characterised by immunocytochemistry and compared to human preadipocytes sourced commercially. The secretion of FGF, adiponectin and …
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Investigating the role of a FAM111B mutation in hereditary fibrosing poikiloderma (POIKTMP) using induced pluripotent stem cell (iPSC) model
… RNA expression of pro-fibrotic markers (COL1A1; COL3A1; α-SMA) was similar between patient and control iPSC-MSCs. Collagen staining and quantification also showed no statistical differences between patient and control cells. These results suggest that FAM111B does not directly alter the …
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Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone
… reduce transcript levels of COL11A1, COL3A1, TGFβ1, TGFβ3, DMT and LOX3 in a time-depenedent manner; (3) expression of collagen I and III proteins were reduced by HF in a time-dependent manner; (4) PDGF-stimulated activation of the MAPK and SRC signaling pathways is not significantly …
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Developing a Drug Delivery System for Treatment of Vocal Fold Scarring
… maintaining down regulation in the expression of COL3A1 and COL1A2 over the long term. While an ELISA showed that dexamethasone only decreased the deposition of the pro-inflammatory cytokine interleukin-6 over the long term, but had no impact on the other three pro-inflammatory cytokines …