Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"COL1A2"”.
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Glomerulosclerosis in the Col1a2-deficient mouse model : homotrimer pathogenesis and MMP expression
The Col1a2-deficient (oim) mouse model exclusively synthesizes homotrimeric type I collagen due to the lack of functional pro [alpha] 2(I) collagen chains. The mouse develops a type I collagen glomerulopathy that has previously been shown to initiate postnatally and progress in a gene …
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The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
… of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… could be temporally activated with tamoxifen (Col1a2-CreERT), undergo targeted genetic recombination in aortic fibroblasts. Using mT/mG Cre-reporter mice harboring Col1a2-CreERT, I provide evidence that Col1a2-CreERT is activated by tamoxifen in both adventitial fibroblasts and in vascular …
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THE ROLE OF OMEGA 3 FATTY ACIDS IN CAPSULAR CONTRACTURE AROUND THE BREAST IMPLANTS
… (Capsular Thickness) and PCR Analysis (tgfb2/COL1A2) were performed to evaluate the grade of fibrosis. Results.:Capsular thickness and tgfb2/COL1A2 gene expression were significantly lower in treatment group. Discussion:This study s results suggest that Omega 3 supplement seems to be effective …
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The Influence of Preovulatory Estradiol on Uterine Transcriptomics and Proteomics Around Maternal Recognition of Pregnancy in Beef Cattle
… 253 were downregulated (CR2, CDH4, TROAP, COL1A2) and 179 were upregulated (PRSS8, FABP3, IDO1, MUC13, CXCL10) in the highE2/conceptus group. There were 48 differentially expressed proteins (DEPs) among the highE2/conceptus and lowE2/conceptus groups (19 upregulated, 29 downregulated in the …
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INTERACTION OF NEGATIVE PRESSURE WOUND THERAPY AND COMPOSITE BIOMATERIALS FOR SPINAL FUSION
… gene expression of Runx2, OSX, ALP, OPN, COL1A2, and HIF-1α were elevated in fully differentiated bone marrow mesenchymal stem cells (MSCs), which were cultured on BRM and treated with subatmospheric pressure. When BRM and/or NPWT were implemented in rabbit and sheep models, the bone …
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Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats
… genes. Pdgf-a, Pdgf-c, Pdgf-rα, Tgf-β, and Col1a2 gene expression was also measured in vitro in RLF and NR8383 rat alveolar macrophages in response to CNT or CB with and without LPS. In vivo, CNT and CB caused fibroproliferative, granulomatous lesions, which were located primarily in the …
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Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.
… the presence of translational changes in Col1a1, Col1a2, and Spp1 highlighted effects of SMN deficiency on translational regulation, in the absence of transcriptional alterations. Validation studies in both mice and SMA patient-derived fibroblasts further underscored the potential of translational …
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Skeletal muscle weakness and mitochondrial dysfunction in the osteogenesis imperfecta murine (oim) model
… in the type I collagen genes, COL1A1 and COL1A2, approximately 85 % of the time with the remaining 15 % of cases arising from mutations in genes involved in posttranslational modification of type I collagen, osteoblast maturation or mineralization. OI is a heterogeneous disorder that can …
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Developing a Drug Delivery System for Treatment of Vocal Fold Scarring
… down regulation in the expression of COL3A1 and COL1A2 over the long term. While an ELISA showed that dexamethasone only decreased the deposition of the pro-inflammatory cytokine interleukin-6 over the long term, but had no impact on the other three pro-inflammatory cytokines tested.</p> …