Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"COL11A1"”.
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Construction of a COL11A1 Transgene Vector
… Mice homozygous for this null mutation in the Col11a1 gene do not express the α1 chain of type XI collagen. This results in a functional knockout of type XI collagen, leading to insufficient skeletal development and perinatal lethality. Objective: 1) To construct a transgenic expression vector …
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An investigation of DNA sequence variants in genes that regulate collagen fibrillogenesis and predisposition to musculoskeletal soft tissue injuries
… of polymorphisms within the COL5A1, MIR608, COL11A1 and COL11A2, genes with AT and/or ACL injuries in Caucasian populations. These aims were explored in three studies: i) Determine whether the COL5A1 rs71746744 (-/AGGG) and rs1134170 (A/T) polymorphisms and the MIR608 rs4919510 (C/G) …
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Genetic risk factors for overuse and acute musculoskeletal injuries
… several collagen gene (COL1A1, COL5A1, COL6A1, COL11A1, COL11A2 and COL12A1) variants with chronic lower limb tendinopathies, such as Achilles tendinopathy, and other exercise-associated phenotypes involving the musculoskeletal system. These genes encode for important structural components of …
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An Integrated Bioinformatics Approach for the Identification of Melanoma-Associated Biomarker Genes. A Ranking and Stratification Approach as a New Meta-Analysis Methodology for the Detection of Robust Gene Biomarker Signatures of Cancers.
… EGFR, FGFR2, FGFR3, IL8, PTPRF, TNC, CXCL13, COL11A1, CHP2, SHC4, PPP2R2C, and WNT4). Of these, CXCL13, COL11A1, PTPRF and SHC4 are components of the MAPK pathway and were validated by immunocyto- and immunohisto-chemistry. These proteins were found to be overexpressed in metastatic and …
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Genetic, Cellular and Ultrastructural Mechanisms in Retinal Detachment
… to this pathway. Another family had biallelic *COL11A1* variants identified, highlighting that variants affecting exon 9 will have a dominantly ocular effect, compensating for an otherwise lethal homozygous *COL11A1* null variant. The posterior hyaloid membrane (PHM) was extracted from cadaveric …
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Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone
… HF can significantly reduce transcript levels of COL11A1, COL3A1, TGFβ1, TGFβ3, DMT and LOX3 in a time-depenedent manner; (3) expression of collagen I and III proteins were reduced by HF in a time-dependent manner; (4) PDGF-stimulated activation of the MAPK and SRC signaling pathways is not …