Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 67 for “"CNV"”.
-
Analysis of the CNV waveform in the time and frequency domains.
The Contingent Negative Variation (CNV) response of the Electroencephalogram (EEC) is often obscured by the background EEC and/or ocular artefacts (OAs). These necessitate the application of a variety of signal processing techniques to reduce the influence of such phenomena on the measured signal. …
-
Molecular characterization of the cucumber necrosis virus coat protein gene
A cucumber necrosis tombusvirus (CNV) mutant which lacks the coding sequence for the coat protein protruding domain, PD(-), was constructed by site-directed mutagenesis of an infectious CNV cDNA clone, pK2/M5 (wild-type, 4701 nt). Transcripts of PD(-) were infectious in Nicotiana clevelandii, …
-
Developments in signal processing for computerised diagnosis in clinical neurophysiology
… known as the contingent negative variation (CNV) in order to aid detection of schizophrenia, Parkinson's disease (PO) and Huntington's Disease (lID). A data recording system was constructed and used to obtain data from 20 schizophrenic patients, 16 PO patients, 21 -at-risk- of HD patients, 11 …
-
Phenotypic and transcriptomic consequences of ribosomal DNA copy number variation in Caenorhabditis elegans and Saccharomyces cerevisiae
… repeat arrays, with copy number variation (CNV) commonly observed in inter- and intra-species comparisons. rDNA CNV has been primarily studied in the budding yeast Saccharomyces cerevisiae, where an environmentally sensitive copy number amplification mechanism corrects for repeat loss from …
-
Accelerated Adaptation through Stimulated Copy Number Variation in Saccharomyces cerevisiae
… individuals is termed copy number variation (CNV) and is rife across eukaryotic genomes. CNV is of clinical importance as it has been implicated in many human disorders, in particularly cancers where is has been associated with tumour growth and drug resistance. The copper-resistance gene CUP1 …
-
Comparative analysis of algorithms for identifying copy number variation in array CGH data
… gains in the copy number (Copy Number Variation, CNV) at random positions corresponding to real probes covering human genome and by adding white Gaussian noise. The white Gaussian noise was generated with the help of program provided by Dr. Nadia Chuzhanova. Two studies of simulated data are …
-
Identification of Genetic Copy Number Variants in Neurodevelopmental Disorders from Genome Sequence Data
… Genetics (including copy number variants, CNVs) plays a central role in many of these disorders, but is yet to be fully understood. Many bioinformatic CNV detection tools have been developed to identify CNVs from whole exome or whole genome sequence reads. However, there are no established …
-
Mechanistic and therapeutic evaluation of a novel antiantiogenic small molecule
Choroidal neovascularization (CNV) is the vision-threatening characteristic of wet age-related macular degeneration (AMD), a major cause of blindness affecting almost 2 million elderly Americans. The current approved treatments target the dominant angiogenic mediator, vascular endothelial growth …
-
Decoding Brain Somatic Mosaicism with New Single-Cell Copy Number Analysis Methods
Copy number variants (CNVs) represent a significant but understudied form of somatic variation in the human brain, with potential implications for neurodevelopment, aging and disease. While single-cell whole-genome sequencing (scWGS) enables genome-wide profiling at single-cell resolution, existing …
-
Influence of symmetry on the stability behaviour of plane and space frames
… Finite element models created in Abaqus of the Cnv plane and space frames, and Dnh space frames. These finite element models were then used to conduct more detailed investigations of the influence of symmetry on the stability behaviour of plane and space frames. This study found that for plane …
-
Investigation of the role of Glil+ cells in retinal angiogenesis and fibrosis.
… For the one laser choroidal neovascularisation (CNV) model, Gli1-Cre x Tomato mice received 3-4 laser burns per eye to induce choroidal neovascularisation and were monitored over 21 days to assess the expression of Gli1 in the injured retina using fundus imaging and immunofluorescent staining. …
-
Frequency of Copy Number Variants Involving The Sex Chromosomes In A Clinical Setting
<p>Copy number variants (CNVs) are a common finding in the clinical setting and contribute to both genetic variation as well as disease. Recently, studies have described the accumulation of multiple CNVs as a disease modifying mechanism. While it has been characterized how additional CNVs may play …
-
Genic copy number variation associated with abiotic/biotic stress among a set of progenitors of contemporary maize germplasm
… phenomenon that includes copy number variation (CNV), inversions, and translocations that affect an intermediate-scale of genomic sequence. Structural variation has the potential to influence phenotype and play a role in heterosis. My research objective is to identify regions of structural …
-
Investigating the role of the complement system in the pathogenesis of sub-retinal fibrosis in neovascular age related macular degeneration
… characterised by choroidal neovascularisation (CNV), which is the growth of newly formed blood vessels into the retina. A neovascular lesion is formed, and the end stage of nAMD is macular fibrosis in which the neovascular lesion transitions into a fibrovascular lesion. This fibrosis in the …
-
Dendrimer Based Nanotherapeutics For Ocular Drug Delivery
… inflammation, significantly reduced (~73%) CNV growth at early stage of AMD in rat model of CNV. A combination therapy of D-NAC + D-TA significantly suppressed microglial activation and promoted CNV regression in late stages of AMD without causing side-effects. </p> <p>G4-OH was modified …
-
Investigating the heritability of resistance fueling copy number variation in glyphosate resistant Amaranthus palmeri
Gene copy number variation (CNV) can arise as a response to selection pressure from the environment. Herbicide is one selective agent targeting and promoting the evolution of resistance in agricultural weed populations. In Amaranthus palmeri, CNV of the EPSPS gene, the target of glyphosate …
-
ROLE OF GENOMIC COPY NUMBER VARIATION IN ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT
… have been identified. Copy number variants (CNVs), a form of genetic variation, are DNA regions that have added genetic material (duplications) or loss of genetic material (deletions). The regions may overlap one or more genes possibly affecting their function. CNVs have been shown to play a …
-
Genetic Determinants of Obesity in Relation to Diet, Weight Gain and Mortality
… In paper III, a copy number variant (CNV) in the salivary amylase gene (AMY1) did not associate with obesity traits neither in men nor in women (P>0.05 for all). However, upon stratification by dietary starch intake, BMI decreased with increasing AMY1 CNV in low starch intake group …
-
Molecular characterisation of Diffuse large B-cell lymphomas (DLBCL) diagnosed at Groote Schuur Hospital (GSH)
… single rearrangements or copy number variation (CNV) are classified as DLBCL, Not Otherwise Specified (NOS). Double-hit (DHL) or triple-hit (THL) lymphomas typically have a worse prognosis and outcome compared to DLBCL, NOS. Fluorescence in-situ hybridisation (FISH) is the gold standard …
-
Genetic and Environmental Factors Related to Child and Parent Mental Health in the Context of Intellectual Disabilities
… CYP with rare pathogenic Copy Number Variants (CNVs) in IMAGINE-ID, exploring the genomic predictors of ID/DD and neurodevelopmental and mental health characteristics in this large and diverse group. The results indicate a complex interplay between CNV characteristics, CNV inheritance and …
Page 1 of 4