Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"CNTNAP2"”.
-
Biophysical and Structural Studies of CNTNAP2
… and contactin associated protein-like 2 (CNTNAP2) have an emerging role at synaptic interaction networks. CNTNAP2 is a member of the neurexin superfamily of synaptic cell adhesion molecules; it is localized at the juxtaparanodes of myelinated axons at the Nodes of Ranvier where it mediates …
-
Touching Autism Spectrum Disorder: Somatosensory Abnormalities in Shank3b and Cntnap2 Mouse Models
… nature. This is the case with the Shank3b-/- and Cntnap2-/- mouse models, strains in which the expression of the gene in question is suppressed. The SHANK3 gene encodes for a crucial protein in the structure of the postsynaptic density of glutamatergic synapses. In humans, haploinsufficiency of …
-
The Role of CNTNAP2 in the Development & Evolution of the Human Cerebral Cortex
… focused on Contactin-Associated Protein-like 2 (CNTNAP2), a gene important for neuronal differentiation and synapse formation, for which there is accumulating evidence for differential use in the human cerebral cortex compared with other primates. Previous work in mice has found that loss of …
-
A neural and behavioural investigation of aberrant feeding in animal models of autism spectrum disorder
… of the contactin-associated protein like 2 (CNTNAP2) gene encoding a transmembrane neuronal protein which clusters K+ channels in the nodes of Ranvier. My studies show for the first time that Cntnap2-/- males drink more of sucrose, saccharin and intralipid solutions compared to wild-type (WT) …
-
Brain functional connectivity and its aberrations in mouse models of autism
… in contactin associated protein-like 2 (Cntnap2), a neurexin-related cell-adhesion protein, on functional connectivity. Homozygous mutations in this gene are strongly linked to autism and epilepsy in humans, and using rsfMRI, we showed that homozygous mice lacking Cntnap2 exhibit aberrant …
-
The role of IL-17a in the rescue of ASD-like behavioral phenotypes following immune stimulation in a mouse model of neurodevelopmental disorders
… with mice genetically deficient for Cntnap2, Fmr1, and Shank3. We found that activation of the immune system using lipopolysaccharide (LPS) was sufficient to rescue behavioral deficits within the MIA model, but not the monogenic mutant model mice. Behavioral rescue was correlated with …