Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"CNS-Infection"”.
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The gut-brain axis in seizure susceptibility: A role for microbial metabolite S-equol
… of epilepsy worldwide in central nervous system (CNS) infection, while in neonates the most common cause of seizures is hypoxic/ischemic encephalopathy (HIE). However, in both adults and neonates, current antiepileptic drugs (AEDs) are ineffective in 30-50% of patients, despite the availability of …
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Describing the immune cell profile of ventricular cerebrospinal fluid (CSF) in paediatric central nervous system (CNS) infections
Introduction: Paediatric central nervous system (CNS) infections are associated with high mortality rates and neurological disability in survivors due to brain injury caused by cerebral inflammation. Because the brain is difficult to study, the unique characteristics of the neuroinflammatory …
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Investigating the immune response to central nervous system invasion by Brucella
… in both preventing and resolving established CNS infection in a neurobrucellosis mouse model in an IFN-g-dependent manner. Further analysis of this cytokine revealed that signaling through its receptors, IFN-a receptors, STAT1, and STAT2 all play crucial, interconnected protective roles in the …
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Molecular Mechanisms Involved in Escherichia coli K1 and Haemophilus influenzae Type a Blood-Brain Barrier Impairment
… cross of ions and nutrients from blood into the CNS by active transport. BBB is made of brain microvascular endothelial cells, characterized by the presence of tight inter-endothelial junctions and the lack of fenestrations, and pericytes, the cells closest to brain endothelial cells with which …
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A study of the john Cunningham virus (jcv) seroprevalence among Zambian adults presenting with “meningoencephalitis” to the university teaching hospital, Lusaka, Zambia
… multifocal leukoencephalopathy (PML). Infection with the JCV occurs in childhood and the virus remains quiescent in the body, activating during immunosuppression. Exposure to the virus can be detected by testing for JC virus specific antibodies in an ELISA test. One of the major …
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A study of the john Cunningham virus (jcv) seroprevalence among Zambian adults presenting with “meningoencephalitis” to the university teaching hospital, Lusaka, Zambia
… multifocal leukoencephalopathy (PML). Infection with the JCV occurs in childhood and the virus remains quiescent in the body, activating during immunosuppression. Exposure to the virus can be detected by testing for JC virus specific antibodies in an ELISA test. One of the major …
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Invasion, Replikation und Stadienkonversion von Toxoplasma gondii in permanenten ZNS-Zelllinien der Ratte
Permanente ZNS-Zelllinien der Ratte wurden mit Toxoplasma gondii unter Betrachtung der Invasions-, Replikations- und Stadienkonversionfähigeit des Parasiten infiziert. Additiv zu bekannten Tiermodellen konnte so ein Zellkulturmodell zur Erforschung der zerebralen Persistenz des Protozoons etabliert …
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Understanding the molecular and host determinants of Powassan virus pathogenesis across cellular and animal models
… RNA (vRNA) in both spleen and brain compared to infections with a lineage II infectious clone (WI.97.ic). Notably, NY.19.12 and NY.19.32 share three amino acid mutations in the envelope, NS1, and NS5 proteins. These mutations were engineered into an infectious clone (NY.19.12.ic) to evaluate …