Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CNS regeneration"”.
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Expression and regulation of genes associated with CNS regeneration and plasticity
… pathophysiology 1 B. Factors for the failure of CNS axon regeneration 2 C. Conditioning injury (CI)-induced axon regeneration 3 D. Regeneration associated genes (RAGs) 4 E. Epigenetics 5 F. Neuroepigenetics in CNS injury 8 G. Next generation sequencing (NGS) in epigenomic studies 10 H. Aims of …
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Identification of Roles for Peptidylarginine Deiminases (PADs) In Models of Nervous System Regeneration, Assessing Capacities of Pharmacological PAD Inhibitor Application
… those affecting the central nervous system (CNS). Although PAD2 and PAD4 are currently recognised as the main PADs associated with the CNS, less is understood about the role of PAD3, which has been noted to play roles in CNS regeneration in animal models. This thesis aimed to enhance the …
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Investigating the Role of MicroRNAs in Regeneration and Axonal Pathfinding
During both development and regeneration, axons must navigate through a complex and changing environment to reach their proper synaptic target. To do so, axons utilize a specialized structure, the growth cone, which senses and interprets guidance cues in its surrounding environment to change the …
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Role of microglial senescence in central nervous system injury and regeneration
… macrophages of the central nervous system (CNS). Here, they have many roles, a key one of these being the regulation of myelin health. Myelin is a lipid-rich, insulating layer that wraps around the axons of neurons, allowing for rapid signal transmission. Although microglia promote …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… capacity of the central nervous system (CNS). At the lesion site, the hostile microenvironment which develops within the CNS prevents regeneration. Current therapeutic strategies for traumatic CNS injury aim at patient stabilization and symptoms management, however without promoting …
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An investigation into the involvement of cell adhesion molecules and perineurial cells in endogenous tissue repair following experimental spinal cord injury in the rat
… cord injury are due to the failure of lesioned CNS axons to regenerate. In the past 20 years, considerable progress has been made in understanding the cellular and molecular mechanisms that contribute to the lack of successful regeneration of lesioned CNS axons. To date, however, relatively …