Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"CNS penetration"”.
-
Factors Influencing Topotecan CNS Penetration in Mouse Models
… Bcrp1 and P-gp in determination of topotecan CNS penetration in mouse models by using cerebral microdialysis. Microdialysis sampling of drugs in ventricular cerebrospinal fluid (vCSF) provides insight into drug penetration into the brain across the blood CSF barrier (BCB); however, this method …
-
CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… in the treatment of central nervous system (CNS) tumors such as malignant glioma have only been modest. One particular challenge facing treatment of brain tumors is the delivery of therapeutically effective concentrations of anti-cancer agents to the target site in the brain. The sanctuary of …
-
HIV-associated neurocognitive disorders biomarkers and the response to antiretroviral therapy
… whether this effect differed according to the CNS penetration-effectiveness (CPE) of the regimen used. I also investigated potential HIV-Associated Neurocognitive Disorders (HAND) biomarkers (serum neopterin, osteopontin and neurofilament H) to determine their relationship to the severity of …
-
Investigation of the cellular tropism and in vivo distribution of HIV-1
… to eradicate the virus as many drugs have poor CNS penetration. There have been concerns that sub-optimal levels of drugs in the CNS may support the evolution of drug resistant variants. Alternatively, low levels of drugs may allow growth of drug sensitive variants which could reseed the …
-
Characterizing and targeting the genomic consequences of ATRX deficiency in glioma
… despite suboptimal central nervous system (CNS) penetration. Additionally, we conducted proof-of-concept studies in sarcoma models and found that CX-5461 induces dose-sensitive lethality, enhances replication stress and DNA damage, and induces G2/M cell cycle arrest in ATRX-deficient sarcoma …
-
Regulation of P-glycoprotein at the Blood-Brain Barrier
… suffer from some type of central nervous system (CNS) disorder (WHO, The World Health Report, 2001). This includes depression, epilepsy, multiple sclerosis, brain tumors, Alzheimer’s and Parkinson’s disease, as well as infections of the brain such as meningitis and HIV encephalitis. Consequently, …
-
ROLE OF PINCH IN ABERRANT TAU PHOSPHORYLATION IN HIV CNS DISEASE
… brings a unique set of central nervous system (CNS) complications including more rapid onset and progression of age-related diseases, loss of protein quality control and accumulation of aberrant proteins, such as hyperphosphorylated Tau (hpTau). In this context, we have discovered a new …
-
Treatment of HIV associated neurocognitive disorders
… virus (HIV) invades the central nervous system (CNS) as early as 8 days after HIV infection, causing a wide spectrum of neuropathological changes including HIV associated neurocognitive disorders (HAND). HAND is a spectrum of cognitive impairment, which in its most severe form cause marked …