Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CNS HIV"”.
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A Novel Elvitegravir Nanoformulation for Drug Delivery Across the Blood-Brain Barrier to Suppress HIV-1 in Macrophages and Microglia
… decreased the morbidity associated with HIV-1 infection. However, the prevalence of HIV-1-associated neurocognitive disorders (HAND) is still increasing. The appearance and persistence of HAND are partially due to the entry of HIV-1-infected monocytes into the brain. Within the central …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
HIV-associated neurocognitive disorders (HAND) affect up to 50% of HIV-infected adults despite potent viral suppression with antiretroviral therapy (ART) and are associated with persistent neuronal damage, monocyte/macrophage activation, chronic inflammation, and oxidative stress. Heme oxygenase-1 …
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
HIV-associated neurocognitive disorders (HAND) affect 30% of infected patients despite suppressive antiretroviral therapy (ART) and are associated with chronic immune activation and oxidative stress within the systemic circulation and central nervous system (CNS). Pathological studies of …
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Dynamics of HIV coreceptors and their utilization by plasma and cerebrospinal fluid HIV-1 isolates
HIV-1 infection of CD4+ immune cells requires the assistance of cellular coreceptors. The regulation of these receptors is highly dynamic. In addition to the major coreceptors, CCR5 and CXCR4, several alternative coreceptors mediate entry for selected HIV isolates in vitro, although their role in …
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ROLE OF PINCH IN ABERRANT TAU PHOSPHORYLATION IN HIV CNS DISEASE
Aged HIV-positive (HIV+) individuals represent a large proportion of the HIV population as life spans are extended significantly by successful antiretroviral therapy. Increased age with HIV infection brings a unique set of central nervous system (CNS) complications including more rapid onset and …
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An investigation of a neuro-inflammatory profile of HIV-associated neurocognitive disorders
Background HIV-associated neurocognitive disorder (HAND) is the consequence of the effects of HIV-1 within the central nervous system (CNS). HIV-associated neurocognitive impairment differs in severity with milder forms presenting in 50% of people living with HIV (PLWH), regardless of treatment …