Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"CNS Disease"”.
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ROLE OF PINCH IN ABERRANT TAU PHOSPHORYLATION IN HIV CNS DISEASE
… brings a unique set of central nervous system (CNS) complications including more rapid onset and progression of age-related diseases, loss of protein quality control and accumulation of aberrant proteins, such as hyperphosphorylated Tau (hpTau). In this context, we have discovered a new …
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Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease
… sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that is a leading non-traumatic cause of disability in young adults. The 18 kDa Translocator Protein (TSPO) is a mitochondrial protein and positron emission tomography (PET)-imaging target that is highly …
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ApoE Receptors in Alzheimer's and CNS Function
Alzheimer's disease (AD) is a currently incurable neurodegenerative disorder and the most common form of dementia over age 65. The predominant genetic risk factor for AD is the ε4 allele of apolipoprotein E (ApoE4). Other genes related to lipid metabolism and lipoprotein receptor signaling have …
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The emergence of cryptococcus gattii in British Columbia : veterinary aspects
… identification as a causative agent for human disease; therefore animals may serve as a good sentinel for human cryptococcosis infection. There were 50% more feline than canine cases and disease appeared more commonly in middle aged cats and younger dogs. There was no sex predilection for …
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A diffusion tensor imaging and neurocognitive study of ART-naïve and ART-treated children in Cape Town
… children on ART remain at risk for developing CNS disease, and that this risk extends to physically well ARV naïve slow progressors. The AAN HAND criteria designed for adults was able to identify children and adolescents with important functional cognitive impairments who don't fit criteria for …
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Astrocyte-mediated immune modulation during mycobacterial infection
Central nervous system tuberculosis (CNS-TB) is the severest clinical extra-pulmonary manifestation of tuberculosis (TB) disease and constitutes approximately 1% of global cases. Little is known about the cells that regulate immune responses during CNS-TB infection. Microglia are the prime resident …
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Studies on the Damage Associated Molecular Patterns (DAMPs)-induced Inflammatory Events in the Brain Immune Cells
… multifaceted functions in sterile inflammatory diseases. Brain inflammation is a process of host defense against infection or injury. Microglial cells and astrocytes, major immune effector cells, have a pivotal role in the brain inflammation. Thus, to understanding how microglia and astrocytes …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… to infections in the central nervous system (CNS) and have a greater risk of viral infections and encephalopathies. Neurotropic viral infections can lead to blindness, hearing loss and neurological deficiencies such as cognitive impairment, epilepsy, and even death in the neonatal and …
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Characterizing the Cellular Response to Astrovirus Infection in the Central Nervous System
<p>Central nervous system (CNS) diseases caused by infectious agents pose significant health challenges, often leading to severe neurological dysfunction with high morbidity and mortality rates. Astroviruses (AstVs), traditionally known for causing gastroenteritis, have recently been identified as …