Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 880 for “"CNS"”.
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Mitochondrial metabolism and CNS myelination
… pressures rise in the central nervous system (CNS) and induce profound metabolic changes. These changes precede the onset of myelination, a process in which oligodendrocyte precursor cells (OPCs) differentiate and engage with axons to invest them with complex multilamellar sheaths. Myelin …
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CNS Remyelination and the Gut Microbiota
… occur extensively in the central nervous system (CNS), leading to functional recovery and axonal protection. However, remyelination does not always proceed to completion, and its failure is associated with progressive neurological disability. Thus, there is clinical need for interventions that can …
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Analýza rizik kontejnerových nůžek řady CNS-K
Tato diplomová práce pojednává o bezpečnosti strojního zařízení a to kontejnerových nůžek z produkce společnosti Žďas a.s. Žďár nad Sázavou. Po počátečním seznámením se strojem, vytvoření příslušného blokového schématu a vymezení limitů použití bylo cílem provést analýzu rizik u tohoto strojního …
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Rejuvenation of CNS Progenitors via Partial Reprogramming
… largest population of stem cells in the adult CNS and give rise to oligodendrocytes. OPCs play a critical role in myelin regeneration (remyelination), but, like all stem cells, their regenerative capacity declines with age. OPCs progressively fail to differentiate into mature oligodendrocytes …
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Epidemiological Features of Central Nervous System (CNS) Infections in Taiwan and Molecular Investigation of CNS Infections of Unknown Cause
… I explore the epidemiological features of CNS infections using a population-based dataset and analyze CSF samples from patients with meningitis or encephalitis of unknown cause using molecular methods. In the second chapter, I review the literature on the epidemiology of meningitis and …
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Factors Influencing Topotecan CNS Penetration in Mouse Models
… Bcrp1 and P-gp in determination of topotecan CNS penetration in mouse models by using cerebral microdialysis. Microdialysis sampling of drugs in ventricular cerebrospinal fluid (vCSF) provides insight into drug penetration into the brain across the blood CSF barrier (BCB); however, this method …
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Nova Regulation of Alternative Splicing in the CNS
… disorder associated with gynecologic cancer and CNS motor dysfunction, is a neuronspecific nuclear RNA binding protein. The work presented here confirms that Nova-1 acts as a regulator of alternative splicing in vivo. In addition to the known target Nova-dependent splicing regulation, exon 3A of …
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CNS delivery of antisense oligodeoxynucleotides using biodegradable microspheres
Antisense oligodeoxynucleotides can selectively inhibit gene expression provided they are delivered to their target site successfully for a sufficient duration. Biodegradable microspheres have previously been developed for the potential systemic delivery of antisense oligodeoxynucleotides and offer …
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LUMINESCENT 2D COORDINATION NETWORKS (CNS): STRUCTURAL AND EXFOLIATION STUDIES
After the discovery of graphene in 2004, the scientific community has increasingly focused on the investigation of two-dimensional (2D) materials, with the objective of integrating them into new technologies and devices while minimizing their environmental impact. Within the field of materials …
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Membrane Lipids and Synaptic Vesicle Trafficking in the CNS
Most vesicles within a synapse are dormant. The rest participate in synaptic neurotransmission, with a portion of these preferentially fusing first. Moreover, all synapses experience spontaneous neurotransmitter release which may originate from the random exocytosis of vesicles prepared to fuse …
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ApoE Receptors in Alzheimer's and CNS Function
… transport proteins cause central nervous system (CNS) disease are not completely understood. Here, the ApoE receptor family and its ligands and their roles in CNS function and neurological disease were explored. It has been previously shown that ApoE4 renders neurons resistant to the …
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CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… in the treatment of central nervous system (CNS) tumors such as malignant glioma have only been modest. One particular challenge facing treatment of brain tumors is the delivery of therapeutically effective concentrations of anti-cancer agents to the target site in the brain. The sanctuary of …
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Blood-CNS transport mechanisms in pathophysiology and drug delivery
The blood-CNS barriers form a highly selective biological firewall; regulating the<br/>passage of solutes between the blood and cerebral microenvironment. This thesis<br/>modelled the blood-CNS barriers in vivo to determine the transport of nutrients,<br/>metabolic products and drugs across these …
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Microglial succinate receptor 1 (SUCNR1) sustains chronic CNS inflammation
… cell functions in the central nervous system (CNS) inflammatory disorders, such as multiple sclerosis (MS), is still largely unknown. Herein, I first investigated the role of SUCNR1 signalling in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. I found that SUCNR1 …
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Thewingless Signaling Pathway Specifies Fates in the Drosophila Embryonic CNS
… huckebein (hkb), during Drosophila embryonic CNS development. wg is necessary for the formation and specification of adjacent neuroectoderm and neural precursors called neuroblasts. wg is also essential for the specification of an identified neuroblast lineage, NB4-2. Other components of the …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
… conditions, axons of the central nervous system (CNS) are myelinated by oligodendrocytes. However, in response to demyelination, Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), can contribute to CNS remyelination. Although CNS-resident SCs were previously thought …
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Molecular interventions to overcome the ageing of CNS stem cells
… stem cell of the central nervous system (CNS). In the adult, OPCs primarily differentiate into oligodendrocytes, the cell type that wraps neurons with myelin allowing for efficient signal transduction down the axon. Increasingly, the process of adult myelination is understood as a key …
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