Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"CMYC"”.
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Untersuchungen zur CD40 induzierten Expression von A1 in B-Lymphozyten der Maus
… verhindert. Die Überexpression von induzierbarem cMyc-ER in A1 transduzierten Zellen, um damit durch parallele Induktion des ektopischen cMyc-ER den BZR-induzierten Verlust von cMyc auszugleichen, führte nicht zur Wiederherstellung der Proliferationsfähigkeit dieser Populationen. Ektopisches …
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Quantitative analysis of the effect of leflunomide on neural crest cell gene regulation during early embryonic development
… in neural crest specification the proto-oncogene cMyc and cMyc responsive genes are affected. cMyc is implicated in embryonic stem cell transcriptional elongation and is well characterised to play an important role in neural crest specification.
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Ehrlichia chaffeensis E3 Ligase TRP120 Ubiquitinates Tumor Suppressor FBW7 for Degradation to Promote Infection
… oncoproteins (Notch, cyclin E, c-Jun, MCL1 and cMYC). In this study, we demonstrate that TRP120 and FBW7 colocalize strongly in the nucleus by confocal immunofluorescent microscopy and interactions between TRP120 and FBW7 FBOX and WD40 domains were demonstrated by ectopic expression and …
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Targeting the intestinal stem cell niche through energy and metabolism signaling, for colorectal cancer chemoprevention using aspirin and metformin
… transcript levels of stem cell markers LGR5 and CMYC, and inhibited mTORC1 downstream target phosphorylation levels. Utilizing 3-dimentional (3D) sphere formation assays revealed that aspirin and metformin also reduced stem cell function in the HCT116 cell line. Drug combination showed a stronger …
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In Vitro Models of Cellular Dedifferentiation for Regenerative Medicine
… encoding the transcription factors Oct4, Sox2, cMyc, and Klf4 to create a line of naive-like porcine induced pluripotent stem cells (iPSCs). This reprogramming vector was verified first in murine cells, the system in which it was developed. Successful production of both murine and porcine iPSC …
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Quantitative dynamic modeling of transcriptional networks of embryonic stem cells using integrated framework of Pareto optimality and energy balance
… Oct4, Sox2, Nanog, Klf4, Nacl, Rexl, Daxl, cMyc, and Zfp281, and obtained the dynamic connectivity matrix between various pluripotency related gene promoters and transcription factors. The developed model fully describes the self-renewal state of embryonic stem cells.
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Mechanisms of toxicity in cell models of FSHD
… of normally rapidly turned-over mRNAs including cMYC, whose overexpression is associated with cytotoxicity. Moreover, I found that DUX4 expressing cells accumulate large double-stranded RNA (dsRNA) foci within their nuclei, corresponding with induction of the pro-apoptotic PKR dsRNA response …
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Characterization of a Putative Acid Phosphatase in Toxoplasma Gondii and Its Role in Parasite Propagation
… knockdown of GRA44 resulted in loss of host cell cMyc upregulation, a phenotype also seen in translocon member disruption. Therefore, the putative acid phosphatase GRA44, in association with the translocon complex, is critical for host cell manipulation during infection, a process Toxoplasma …
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An immunohistochemical study of beta-catenin in HNPCC colon tumours
… immunohistochemically stained with E-cadherin, cmyc and cyclin 01. The results showed a positive correlation between Ecadherin loss, increased cyclin 01 and a shift in beta-catenin. No significant change in c-myc or correlation between c-myc and a shift of beta-catenin was found. In conclusion …
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Behavioral and genetic characteristics of intestinal cell lineages in health and disease
… and proliferation markers (Creb313, Gob5, Ki-67, cMyc), as well as the ephrin signaling (EphB2 and EphrinBl) were significantly altered in the early stages (7 days) of adenoma formation. A more detailed analysis also separated this derangement in terms of extrinsic factors (e.g. altered cell …
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The Effect of Activation Induced Cytidine Deaminase Phosphorylation and Herpes Virus Uracil Dna Glycosylase On Antibody Diversification
… B-cells reduces the frequency of AID induced IgH-cMYC translocations, suggesting that viral UNG may play a role in protecting the host cell genome from damage. These studies have revealed a novel mechanism by which herpes viruses might impede the host immune system.</p>
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Pin1: WW domain ligands, catalytic inhibitors, and the mechanism
… isomerizes the Ac–LLPpTPPLSPS–NH₂ peptide at the cMyc pThr58 position. Finally, we measured a secondary kinetic isotope effect (2º KIE) to study the Pin1 catalytic mechanism of proline isomerization. The ratio of kH/kD for unlabeled and [d₃]Ser-labeled substrate gave a SKIE value of 1.34 ± 0.01. …
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Expression profile of multidrug resistance genes and proteins in cancerous and stem cells
… transcriptional association between bmil and cmyc, there was an inverse transcriptional association between these genes and cd133 in serum deprived glioma cells, suggesting that bmil may not be essential for the maintenance of glioma stem cells, and 5) CD133+ glioma and normal brain cells …
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Understanding the molecular pathogenesis of HIV-associated Burkitt Lymphoma – the impact of HIV-1 protein Tat on lymphoma driver genes
… Tat was shown to enhance the activity of the cMYC promoter (-2324 bp - +537 bp), which corresponded with elevated c-MYC protein levels in BL cells (Ramos) expressing HIV-1 Tat. By generating sequential promoter deletions, the minimal promoter region mediating HIV-1 Tat induced activation was …
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Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia
… for NOTCH1 target genes (HES1, DELTEX1 and cMYC). However, none of these mutations were associated with treatment outcome. Increased HES1, DELTEX1 and cMYC transcript levels were associated with significant increases in the transcript levels of several chemotherapy relevant genes, including …
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The B55α/PP2A Holoenzyme in Cell Cycle Exit, Maturation/Differentiation, and Cancer
… recruitment of p107 to regulated genes including CMYC. Our results suggest a model where FGF1 mediates rapid dephosphorylation and activation of p107 independently of the CDK activities that maintain p130 and pRB hyperphosphorylated for several hours post p107 dephosphorylation in maturing …
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NOVEL PEPTOID TARGETING CELL SURFACE VIMENTIN FOR LUNG CANCER TREATMENT
… mutations such as alternations of p53, KRAS, and cMyc. We hypothesized that novel cancer-specific cell surface markers may appear due to these oncogenic alternations, and then those can be captured by bead-displayed peptoids. Therefore, we exposed bead-displayed peptoid libraries to those …
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Medulloblastoma: New animal models, preclinical drug testing, and characterising immune infiltrates
… Here, we utilised mutated human variants of CMYC, NMYC, and P53, to transform mouse neural stem cells into tumour forming cells. Tumours were established in C57Bl/6 mice and characterised by histology and RNAseq analysis. Whilst these animal models could not be confirmed to accurately …
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Fusion of bovine fibroblasts to mouse embryonic stem cells: a model to study nuclear reprogramming
… transcription factors (Oct4, Sox2, Klf4, and cMyc; OSKM) present normally in ESCs. It has been shown that iPSCs are equivalent to ESCs in terms of morphology, gene expression, epigenetic signatures, in vitro proliferation capacity, and in vitro and in vivo differentiation potential. However, …
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Untersuchungen zur Expression von Adenosin-Rezeptoren und Enzymen des Adenosin-Stoffwechsels auf der Oberfläche menschlicher lymphoider Zellen
… Mitogene führte sowohl bei EBNA2, wie auch bei cmyc nach ca. 3 bis 6 Stunden zu einem deutlichen Anstieg der A2aAdoR-Niveaus, sowie generell zu einer Abnahme des ADA-Niveaus im Falle der c-myc-Abschaltung. NECA-abhängige Erhöhung des cAMP-Niveaus korrelierte mit den A2aAdoRNiveaus der …