Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"CML"”.
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T-cell activity in CML patients after TKI discontinuation
Tutkielman aiheena oli kroonista myeloista leukemiaa sairastavien potilaiden T-solujen aktiivisuus ja sytokiinituotanto. Potilasmateriaalina oli ns. STOP-tutkimuksen potilaat, joita on seurattu Hematologisessa tutkimusyksikössä vuodesta 2006. STOP- tutkimuksen yhtenä kiinnostuskohteena oli …
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Expression and function of drug transporters in primitive CML cells
Chronic myeloid leukaemia (CML) is a stem cell (SC) disorder initiated by the reciprocal translocation between chromosome 9 and 22, giving rise to the Philadelphia (Ph) chromosome and the resulting expression of the oncogenic fusion protein BCR-ABL. The current first line of treatment is imatinib …
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Defining CP-CML patient subsets associated with poor imatinib uptake and response.
… of chronic phase chronic myeloid leukaemia (CP-CML) patients. Although most patients will achieve excellent clinical (haematological, cytogenetic and molecular) responses on imatinib, it is clear that a subset of patients will respond poorly, or fail imatinib therapy. Currently, up to 35% of …
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The isolation and characterisation of MHC-presented peptides from CML-derived cell-lines, with a focus on post-translational modification
Phosphorylation is a key regulator of protein function and activity, and aberrant kinase activity is implicated in a wide range of malignancies, of which the bcr:abl fusion kinase found in chronic myeloid leukaemia is a classic example. As phosphopeptides are known to be presented by both the MHC …
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Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is caused by the transformation of a primitive hematopoietic cell by the BCR/ABL1 fusion gene that is formed through the chromosomal translocation t(9;22). CML is currently successfully treated with tyrosine kinase inhibitors targeting the ABL1 kinase domain. However, …
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GENERATION OF SYNTHETIC ANTIBODIES AS POTENTIAL THERAPEUTICS TO BLOCK IL3–MEDIATED INNATE IMATINIB RESISTANCE IN CHRONIC MEYLOID LEUKEMIA
… imatinib resistance in chronic myeloid leukemia (CML). Tyrosine kinase inhibitor (TKI), imatinib, is the standard therapy for CML. Although many patients respond to the conventional TKI chemotherapy, the majority relapse upon withdrawal of treatment (Ross et al., 2013) implicating the inability of …
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Biological Mechanisms and Clinical Implications of Bcr-Abl-Induced Mitochondrial Oxidative Stress and Cell Survival In Chronic Myeloid Leukemia
<p>Chronic myeloid leukemia (CML), a myeloproliferative disorder, represents approximately 15-20% of all adult leukemia. The development of CML is clearly linked to the constitutively active protein-tyrosine kinase BCR-ABL, which is encoded by <em>BCR-ABL</em> fusion gene as the result of …
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Collaborative concurrent mapping and localization
… for this concurrent mapping and localization (CML) problem have been implemented for single vehicles, but do not account for extra positional information available when multiple vehicles operate simultaneously. Multiple vehicles have the potential to map an environment more quickly and robustly …
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Estudio analítico de Coupled Map Lattices débilmente acoplados
… problemas es por medio de Coupled Map Lattice (CML), que consisten en un sistema de ecuaciones acopladas cuya variable de estado es continua pero las variables espacio-temporales son discretas. Los CML se utilizan para modelar sistemas en las más diversas ciencias: física, química, ingeniería, …
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Proteasome inhibition in chronic myeloid leukaemia
CML is treated effectively with TKI, however two key problems remain - the insensitivity of CM HSC to TKI and the emergence of TKI-resistant BCR-ABL mutations. BCR-ABL activity is associated with increased proteasome activity and PI are cytotoxic against CML cell lines. We demonstrate that …
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Investigating a co-operative link between TGF-β and Lyn kinase in Chronic Myeloid Leukaemia
Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterised by uncontrolled proliferation of haematopoietic cells driven by the fusion gene Bcr-Abl. The advent of a mechanism specific kinase inhibitor, Imatinib, targeting the constitutively active Bcr-Abl kinase has paved the way …
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The analysis of Bcr-Abl—Nox signalling in chronic myeloid leukaemia
Chronic Myeloid Leukaemia (CML) is a myeloproliferative disorder characterised by increased proliferation of haematopoietic stem cells. CML results following generation of the chimeric protein Bcr-Abl, a constitutively active tyrosine kinase which induces oncogenesis in part by promoting increased …
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Formation and inhibition of advanced glycation endproducts in meat and model systems
… as N[superscript]ε-carboxymethyllysine (CML) level, in cooked meat and fish prepared by general cooking methods recommended by U.S. Department of Agriculture, Food Safety and Inspection Service (USDA-FSIS). We found AGE was detected in all the cooked samples, but the levels depended on …
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Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers
… in different canine malignant lymphoma (CML)classification systems, which lead to incorrect diagnosis and prognosis, necessitated a retrospective study of 103 cases of CML. Histological classification was done according to the Working Formulation, on H&E sections, after standard …
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Repurposing Alzheimer’s disease medications in a drug combination for the study of the crosstalk between cell apoptosis and autophagy in the modulation of cell death in chronic myeloid leukaemia
… of cancers such as chronic myeloid leukaemia (CML). This requires the understanding of the possible interconnection between CML and AD at the molecular level. The overall aim of this research was to study the crosstalk between cell apoptosis and autophagy in the modulation of cell death and to …
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Diet, Adiposity, and Advanced Glycation Endproducts
… levels of serum n-epsilon-carboxymethyl-lysine (CML), a measure of advanced glycation endproducts. In study I, we tested the hypothesis that sRAGE is correlated to adiposity in a young, ethnically-diverse population. Seventy-two healthy adult participants were recruited for the study and …
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Strength out of Weakness: Harnessing Information Gained from the Pair Structure of Composite Marginal Likelihood Estimation
… estimated using composite marginal likelihood (CML) methods, to detect model misspecifications and enhance model fit. <br /><br /> The second paper demonstrates the use of pairwise CML estimation for gradient-based Lagrange multiplier-type tests, enabling the comparison of gradients between …
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Design and Aerodynamic Analysis of Continuous Mold-line link flap
… A concept called continuous mold-line (CML) link flap has been studied rigorously for its impact on the acoustic behavior of the wing. These studies found that eliminating the blunt side tips with a continuous mold-line reduces the noise generated by the wing, drastically. However, very …
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