Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"CMG Helicase"”.
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Treslin and its role in the assembly of the replicative DNA helicase
… protein ring Mcm2–7, which contains weak DNA helicase activity. In order to fully activate the helicase activity, protein co-activators of Cdc45 and GINS have to be recruited to assemble a replicative DNA helicase called the CMG (Cdc45-Mcm2–7-GINS) complex. The active CMG subsequently unwinds …
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In vitro reconstitution of the ubiquitylation and disassembly of the eukaryotic replisome
… genome is copied only once. The Cdc45-MCM-GINS (CMG) DNA helicase which is the core of the eukaryotic replication complex, has been shown to be extensively regulated by post translational modifications, during its assembly. Therefore, it is not inconceivable that the process to unload the …
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The Role of the Protein MTBP in DNA Replication
… and the GINS complex to form the replicative CMG helicase.<br/><br/>In yeast, the proteins Sld2 and Sld3 are CDK substrates that interact with Dpb11, and are required for the assembly of the CMG complex. Sld7 has been reported to associate with Sld3 throughout the cell cycle and regulate the …
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Single-molecule optical trapping studies of the regulation mechanisms of XPD helicase
… organisms to thrive and pass on their legacy. Helicases, as molecular motors, play a critical role in this maintenance by unwinding DNA and RNA to enable replication, repair, and transcription. Harnessing ATP hydrolysis, helicases navigate complex nucleic acid structures, preserving genome …