Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"CMG"”.
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In vitro reconstitution of the ubiquitylation and disassembly of the eukaryotic replisome
… genome is copied only once. The Cdc45-MCM-GINS (CMG) DNA helicase which is the core of the eukaryotic replication complex, has been shown to be extensively regulated by post translational modifications, during its assembly. Therefore, it is not inconceivable that the process to unload the …
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Simulation development and analysis of attitude-control system architectures for an astronaut mobility unit
Control-moment gyroscopes (CMGs) are spacecraft attitude-control actuators which control the spacecraft's orientation and pointing. CMGs operate on electrical power and therefore obey the the conservation of angular momentum. Single-gimbal CMGs are equipped with a high-speed flywheel which can be …
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Treslin and its role in the assembly of the replicative DNA helicase
… assemble a replicative DNA helicase called the CMG (Cdc45-Mcm2–7-GINS) complex. The active CMG subsequently unwinds the parental DNA duplex to provide single-stranded DNA templates for replicative DNA polymerases. The precise mechanism for CMG assembly and activation is still poorly understood. …
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Analysis Of A Dual Scissored-Pair,variable-Speed, Control Moment Gyroscope Driven Spherical Robot
… of spherical robots to control moment gyroscope (CMG) based designs in order to determine which approach is most effective. The first objective was to develop a list of current state of the art designs in order to gain an overall understanding of what the obstacles in this area of research were. …
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Associação entre o desenvolvimento motor e a participação esportiva em crianças dos 6 aos 10 anos de idade
… motor é a coordenação motora global (CMG), considerada como uma condição precedente a aquisição das habilidades motoras. Um aspecto fundamental associado à competência motora durante a infância é a prática da atividade física. Dentre as práticas de atividade física, sabe-se que o …
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The Variable Vector Countermeasure Suit for space habitation and exploration
… containing arrays of control moment gyroscopes (CMGs) which will be controlled to provide viscous resistance to motion against a specified direction. To reduce the coordination and sensorimotor problems seen during and following gravity level transitions, this resistance will be felt in the …
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Mechanism of Mcm10 function during DNA replication
… proteins, Cdc45 and GINS (forming the CMG complex). DNA unwinding cannot proceed, however, until an additional protein, Mcm10, associates with the CMG. Mcm10 continues to travel with the replication fork after stimulating initial DNA unwinding but a function for Mcm10 during DNA …
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The Role of the Protein MTBP in DNA Replication
… and the GINS complex to form the replicative CMG helicase.<br/><br/>In yeast, the proteins Sld2 and Sld3 are CDK substrates that interact with Dpb11, and are required for the assembly of the CMG complex. Sld7 has been reported to associate with Sld3 throughout the cell cycle and regulate the …
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Functional and structural investigations of human replisomes assembled from purified proteins
… At the heart of the eukaryotic replisome is the CMG (CDC45-MCM-GINS) helicase that unwinds the parental DNA duplex to generate single-stranded DNA for initiation of DNA synthesis by Pol α -primase and the replication of both strands by the replicative polymerases Pol ε and Pol δ. Replisomes …
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The development of Zero-G class underwater robots: unrestricted attitude control using control moment gyros
… internal actuation using Control Moment Gyros (CMGs) is proposed to provide Zero-G Class Autonomous Underwater Vehicles (AUVs) with this unique freedom in control.<br/><br/>The equations of motion for a CMG actuated underwater robot are derived and a nonlinear feedback control law formulated …
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Design and Development of a Self-Balancing Bicycle Using Control Moment Gyro
… The system uses a control moment gyroscope (CMG) as an actuator for balancing.
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Design and utility assessment of attitude control systems for EVA task performance
… of single-gimbal control moment gyroscopes (CMGs) to the attitude control system of these spacecraft could substantially improve the stability and pointing accuracy of the platform and could also conserve onboard fuel during missions. This thesis contains a description of recent work …
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Functional dissection of the S. cerevisiae helicase activating factor Cdc45
… Cdc4S and GINS. The resulting Cdc45/Mcm2-7/GINS (CMG) complex unwinds double-stranded DNA at the replication fork. Although it is clear that CMG complex possesses robust helicase activity in vitro that is dependent on GINS and Cdc45, it is unclear how the CMG is assembled in vivo. Moreover, the …
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Mixed Control Moment Gyro and Momentum Wheel Attitude Control Strategies
… control laws that use control moment gyros (CMGs) and momentum wheels are derived with nonlinear techniques. The control laws command the CMGs to provide rapid angular acceleration and the momentum wheels to reject tracking and initial condition errors. Numerical simulations of derived …
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¿CHIOS MASTIC GUM FROM PISTACIA LENTISCUS AS A MODULATOR OF INFLAMMATION AND INTESTINAL BARRIER FUNCTION: AN IN VITRO AND CLINICAL INVESTIGATION.¿
… for complementary approaches. Chios Mastic Gum (CMG), a resin from Pistacia lentiscus, has shown anti-inflammatory and barrier-protective properties in preclinical models. During this PhD project, an integrated clinical and mechanistic study was conducted to evaluate CMG (trade name Selpic) in …
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Single-molecule optical trapping studies of the regulation mechanisms of XPD helicase
… of the eukaryotic Drosophila melanogaster CMG helicase, a ring-forming heterohexamer that drives replication fork progression. Although previous single-molecule studies provided insights into CMG, detailed high-resolution mechanics remained unclear. Using optical tweezers, I observed two …
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Numerical simulation and optimization of cyclic and continuous fluid injection for geothermal energy recovery
… this research uses Computer Modelling Group (CMG) reservoir simulator software to simulate the energy extraction in the conventional water base geothermal reservoirs that locate at Western Canada Sedimentary Basin and the area in the City of Regina. The simulation of the primary recovery (rely …
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Utilization of Carbonated Water Injection (CWI) as a Means of Improved Oil Recovery in Light Oil Systems: Pore-Scale Mechanisms and Recovery Evaluation
… that the tuned PR-EOS model constructed using CMG WINPROP is capable of accurately reproducing the fluids’ basic characteristics, as well as the properties of CO2–oil and CO2–brine mixtures, such as saturation pressure and solubility. The fluid model was incorporated into the compositional and …
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Transient Shape Factors for Thermal Flow Simulation in Fractured Reservoirs
… shape factor formulations. In this study, the CMG STARS simulator is used to estimate and validate the proposed transient shape factor. A MATLAB code is developed and coupled with the CMG STARS to compute transient shape factor (TSF). This new technique describes the most appropriate way of …
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The Roles of the Mcm2-7 Tails in Replication Initiation
… active replicative helicase complex called the CMG (Cdc45-Mcm2-7-GINS) complex. CMG complex formation is followed by DNA unwinding, replisome assembly, DNA synthesis, and finally replication termination. The Mcm2-7 helicase is involved in every step of this process, from the earliest stages of …
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