Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"CLU"”.
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Clusterin: A Regulator of Glial Biology and Alzheimer’s Disease Pathogenesis
… play significant roles in AD pathogenesis. Clusterin (CLU), also known as apolipoprotein J, is the third most prominent risk gene associated with late-onset AD (LOAD). The precise role of CLU in the brain and in LOAD pathogenesis remains unclear. Multiple pieces of evidence have pointed to …
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Independent Functions Of Clueless In Differential Integrin Secretion And Mitochondrial Quality Control In Drosophila Muscle
Drosophila Clueless (Clu) and its conserved orthologs are known for their role in the prevention of mitochondrial clustering. Here, we uncover its independent roles in the delivery of integrin subunits and the regulation of mitochondrial quality control (MQC) in muscles. In clu mutants, αPS2, but …
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Evidenze molecolari del ruolo antiproliferativo e pro-apoptotico della clusterina in cellule epiteliali prostatiche umane
The Clusterin (CLU) gene produces different forms of protein products which vary in their biological properties and distribution within the cell. Both the extra- and intracellular CLU forms regulate cell proliferation and apoptosis. Dis-regulation of CLU expression occurs in many cancer types, …
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An investigation into the regulation and expression of the tumour suppressor gene clusterin in oral, cervical and nasopharyngeal cancer
Clusterin (CLU) is a multifunctional glycoprotein widely expressed as two isoforms. One isoform, sCLU is secreted, cytoplasmic and anti-apoptotic, the other, nCLU, is nuclear and pro-apoptotic. Seven genes, DKK3, TIMP1, CADM1, AKAP12, KLF4, RNASET2 and CLU were identified to be candidate tumour …
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Investigating the effects of extracellular biomolecules on Aß1-42 oligomer uptake and trafficking by microglia cells
… extracellular biomolecules, namely the chaperone clusterin (Clu) and the antimicrobial enzyme lysozyme, an important component of the innate immune system. Microglia cells are the primary immune cells of the brain and as such, considered to be the first line of defense against intruders. In more …
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DNA methylation of the clusterin promoter: Associations with Alzheimer’s Disease risk and related phenotypes
… risk. The third most associated AD risk gene is Clusterin (CLU), is also involved in the cholesterol/lipid pathway. CLU has been implicated in both a protective and aggravating role in AD making it a compelling gene for further study. The identification of a fluid-based AD biomarker/s has become …
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The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
… Growth Factor p75 (LEDGF/p75) and Clusterin (CLU). Results revealed a robust pattern of GR-induced upregulation of LEDGF/p75 and CLU in African-American (AA) PCa cells compared to European-American (EA) PCa cells. We also detected increased GR transcript expression in AA PCa …
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Collaborative methods in social movement organizing : a case study of long-term alliance development and energy efficiency planning in Massachusetts
… Through the history of Community Labor United (CLU), a Boston-based long-term community-labor alliance, I establish the existence of mutual benefits between organizing and collaborative methods for creating solutions to complex problems. The prerequisites for the application of collaborative …
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Plxna4 and its role in neuronal survival in the developing zebrafish hindbrain
… indicates that the secreted heat shock protein Clusterin is a candidate ligand to mediate apoptosis through Plexina4, as Clusterin is known to promote cell survival, and bind Plxna4. I find that clu is expressed by the floorplate of the embryonic zebrafish hindbrain. Epistasis experiments reveal …
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Optimizing Feeding Efficiency in Dairy Cows Using a Precision Feeding System
… milk production, and increased IOFC compared to CLU diets. Additionally, both IND and CLU diets outperformed PEN solutions. This work established methods for deriving efficient diet solutions for individual animals and using clustering techniques for more precise pen-level feeding. In Chapter 6, …
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Structure-function studies of SLC15 peptide transporters
… transporter (POT) family of proteins includes mammalian PepT1 (SLC15A1; high capacity, low affinity) and PepT2 (SLC15A2; low capacity, high affinity) transporters which are involved in the co-transport of protons and di- and tri- peptides and drugs similar in structure (peptidomimetics). …
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Breeding parameters of great cormorants (Phalacrocorax carbo carbo) at mixed species colonies on Prince Edward Island, Canada
… CCUibo dCUtbo) and Double-crested Cormorants (P. CLU/uXuA CMJhLtllb) were examined at two mixed species colonies at Cape Tryon and Durell Point, Prince Edward Island from 1976 to 1978. Differential access to nests at the two colony sites resulted in more complete demographic data for P. CCUibo …
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Early Onset Alzheimer’s Disease Markers in Mouse Hippocampus Unveiled by Single-Cell Transcriptomic Analysis Following Cranial Radiotherapy
… specific altered pathways following radiation, including synaptic transmission, chromatin remodeling and pathways associated with early-onset Alzheimer’s disease. The <em>Ttr</em> gene was consistently downregulated across all cell types in the hippocampal CA1-3 regions, along with other …
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Hypochlorous Acid Mediated Damage of Chromatin
… 5-chlorocytosine (ClC) and 5-chlorouracil (ClU) as well as the oxidation damage products 5- hydroxycytosine (HOC) and 5-hydroxyuracil (HOU). Histone damage by HOCl can be measured by quantitation of 3-chlorotyrosine and 3,5-dichlorotyrosine, stable and unique markers of protein damage caused …
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The novel phosphorylation site PLCγ2 Y1217 facilitates the TREM2 amyloid-β sensing pathway in microglia
… in genes highly enriched within microglia and include *BIN1*, *TREM2*, *PLCG2* and *CLU*. The TREM2 R47H mutation carries the second highest genetic risk factor for LOAD and one allele increases risk of AD three-fold. TREM2 is an immunoreceptor expressed on microglia and detects anionic damage …
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A study on endocrine disrupters in the environment through the microarray technology
… and capillars. In addition, other genes are included to monitor different pathways that are related to disease states; control of cell proliferation, apoptosis or cancer related genes. Currently these kinds of investigations are already in process, but by other methods which are more time …
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Identification of Functional Variants in Alzheimer's Disease-Associated Genes
… common variants in ABCA7, BIN1, CD33, CD2AP, CLU, CR1, EPHA1, MS4A4A, and PICALM that contribute to AD; however, the most-significant variants in these loci are located within non-coding regions and have no direct functional impact on AD pathogenesis. We hypothesized that if PLD3 and TREM2 are …
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How States are Meeting the Highly Qualified Teacher Component of NCLB
As part of the reauthorization of the Elementary and Secondary Education Act the federal government has added the requirement that all schools receiving Title I funds must have "highly qualified teachers" in every classroom. The term "highly qualified teacher" comes from the No Child Left Behind …