Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"CLR"”.
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Transcriptional Regulation of Clr-b (Clec2d) in Health and Disease
… NKR-P1B inhibitory receptor. The NKR-P1B-ligand, Clr-b, is broadly expressed by normal healthy cells, yet rapidly downregulated during pathological alterations, resulting in NK cell disinhibition via NKR-P1B. This thesis investigates transcriptional regulation of Clr-b during health and disease. A …
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Modulation of Clr-b Ligand for the Inhibitory NKR-P1B NK Cell Receptor in Response to Transformation and Genotoxic Stress
… recognition of MHC-I. The ligand pair NKR-P1B:Clr-b participates in “missing-self” recognition of tumour and infected cells, but the role of this axis in sensing stressed cells remains unknown. This thesis focuses on the modulation of Clr-b by genotoxic stress and transformation In the first …
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
… recognition, and more specifically, the NKR-P1B:Clr-b receptor-ligand system and its role in bone marrow transplantation. In the first results chapter, we generated hybridoma clones producing monoclonal antibodies against another inhibitory receptor in the Nkrp1 receptor family, NKR-P1G via the …
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CGRP family of G protein-coupled receptors and their signalling in human cardiovascular cells
… human calcitonin receptor-like receptor (CLR) in its native cellular environment. Therefore, primary human cardiovascular cells, gene editing techniques, and a host of intracellular assays were used to study the signalling properties of this GPCR family, revolving around the CLR, to …
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Investigating the molecular pharmacology of class A and B G protein-coupled receptors
… (A2AR), the Calcitonin receptor-like receptor (CLR), the Calcitonin receptor (CTR), corticotrophin-releasing factor receptor type 2 (CRFR2) and the growth hormone-releasing hormone receptor (GHRHR). For the A2AR, agonist-mediated cAMP production and β-arrestin recruitment is studied, as well as …
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Sites of interaction between calcitonin-family peptides and their receptors
… receptors are calcitonin receptorlike receptor (CLR) or calcitonin receptor (CTR) and receptor activity-modifying protein (RAMP) complexes. RAMP1 with CLR constitutes the CGRP receptor whereas RAMP2 or 3 with CLR generates the AM receptors. Amylin receptors are formed from CTR interactions with …
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Genética do acamamento em trigo (Triticum aestivum L.) e a identificação do caráter para seleção
… colmo, método internacionalmente conhecido com cLr, como sendo a metodologia mais eficiente para seleção indireta em populações segregantes. Foi também mensurada a dissimilaridade genética entre dez cultivares de trigo recomendadas para cultivo no Rio Grande do Sul e Santa Catarina, no ano 2000, …
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Mechanisms of Innate Immune Dysfunction During Mycobacterium tuberculosis and HIV Co-infection
… this work identified a novel role for the CLR Macrophage Galactose-type Lectin-1 (MGL-1) in a mouse model (C57BL/6 and MGL-1-/-) of experimental tuberculosis. Murine macrophages upregulated MGL-1 following in vitro and in vivo exposure to Mtb, while MGL+ cells accumulated at sites of …
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Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors
… response to GLP1. The calcitonin-like receptor (CLR) is known to interact with all three RAMPs to generate functionally distinct receptors. Biased G protein-mediated signalling of CLR has been well-studied, but the role of RAMPs in CLR desensitisation and internalisation has been relatively …
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SEX DIFFERENCES IN GENE EXPRESSION AND PAIN-RELATED BEHAVIORS IN A PRECLINICAL MODEL OF MIGRAINE
… receptor called calcitonin-like receptor (CLR), a receptor activity-modifying protein (RAMP1), and a coupling protein, receptor component protein (RCP). Thus, the availability and sensitivity of this receptor is subject to regulation at numerous levels. The objectives of this study were to …
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Role of Mincle in Immune Responses to Orientia tsutsugamushi infection
… of Mincle, a C-type lectin receptor (CLR), in innate immunity to O. tsutsugamushi. Following lethal infection in C57BL/6 mice, pulmonary differential expression analysis revealed Mincle (Clec4e) among the top 5 greatest up-regulated genes, accompanied with CLR signaling partners …
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Role of Mincle in Immune Responses to Orientia tsutsugamushi infection
… of Mincle, a C-type lectin receptor (CLR), in innate immunity to O. tsutsugamushi. Following lethal infection in C57BL/6 mice, pulmonary differential expression analysis revealed Mincle (Clec4e) among the top 5 greatest up-regulated genes, accompanied with CLR signaling partners …
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Computational and experimental investigation of G protein-coupled receptor signalling mechanisms
… of the Calcitonin Receptor-Like Receptor (CLR). Results revealed a previously unknown interaction between CLR, G protein Receptor Kinases (GRKs), and β-arrestins. Further investigation into CLR’s desensitisation by β-arrestins revealed interesting and unexpected results. Using Förster …
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Removal of Metformin and Clarithromycin from aqueous media using Magnetic Brewery Spent Grain
… metformin (MF) and clarithromycin (CLR). Response surface methodology (RSM) was applied to identify optimal adsorption parameters for the most promising material, magnetic brewery spent-grain biochar (MBSG). Under these optimal conditions removal efficiencies of 100% and 99% were …
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Steps to the identification of the residue of the cultural heritage landscape of the University of Pretoria's Hatfield campus 1910-1960
… Park Service's Cultural Landscape Report (CLR). The limitation to the thesis was Part 1: Site History, Existing Conditions, Analysis and Evaluation of the CLR to the University of Pretoria's Hatfield Campus for the period 1910 to 1960. The study highlighted that the Hatfield Campus does …
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Infinitely Many Solutions to Asymmetric, Polyharmonic Dirichlet Problems
… eigenvalue estimates to find alternatives of the CLR inequality specifically designed for our particular nonlinear PDE applications. Chapters 2 and 3 comprise the tools of the perturbation argument. In chapter 4 we bring everything together and prove our main results. We also include new results …
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A .net based resource sharing framework
… as Web Services, the Common Language Runtime (CLR) and popular encryption algorithms.
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REDUCING ANTIMICROBIAL RESISTANCE RISKS AND ANTIBIOTIC USAGE IN DAIRY FARMING: MICROBIOLOGICAL INSIGHTS AND ALTERNATIVE STRATEGIES
… High penicillin resistance (69%), especially in CLR strains (88%), was observed, along with 51% resistance to amoxicillin plus clavulanate. All strains were susceptible to cephalosporins and oxacillin, with low macrolide resistance (4%) and multidrug resistance (6%). AMR genes were linked to …
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Modulation of cyclic adenosine monophosphate (cAMP) signalling and its therapeutic potential: pharmacological characterisation of PDE inhibitors
… receptor 4 (PAR4) and calcitonin-like receptor (CLR). Using PAR4 transiently transfected HEK293T cells, both cognate ligand and agonist peptide were used to profile PAR4 signalling including RAMPs-trafficking to the plasma membrane, promoting intracellular calcium release and recruiting …
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Unsupervised gene regulatory network inference on microarray data
… Context Likelihood or Relatedness Network (CLR), and Maximum Relevance Minimum Redundancy (MRNET) are used. The performance of time-series data as well as steady-state data based tool algorithms is compared by calculating their accuracy. The accuracy is calculated by comparing gene …
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