Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"CLN5"”.
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Spinal cord pathology of ovine CLN5 and CLN6 neuronal ceroid lipofuscinoses (Batten disease) : A thesis submitted in partial fulfilment of the requirements for the Degree of Master of Agricultural Science at Lincoln University
… or CLN10-14. Two naturally occurring forms of CLN5 and CLN6 NCL exist in Borderdale and South Hampshire sheep breeds respectively. These large animal models recapitulate the clinicopathological features of the human disease and have been instrumental in understanding the human condition and in …
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Systematic Analysis of disease pathways in Congenital, Infantile and Juvenile Neuronal Ceroid Lipofuscinoses
… (CLN10), infantile, late-Infantile (CLN1, CLN5) and juvenile NCL (CLN3) in the human brain. Firstly, we examined the synaptic proteome in a cathepsin D (Ctsd / Cln10) knockout mouse model of congenital NCL, where the synaptic pathology resembles that of patients. Quantitative mass …
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Investigating novel therapeutic approaches and targets to prevent synapse degeneration
… large animal model of neurodegenerative disease: CLN5 Batten sheep. Subsequently, we explored two of these individual synaptic protein targets in more detail (calretinin and α-synuclein), to further investigate their contribution to synaptic function and stability. Calretinin is a poorly …