Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"CLN3"”.
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Astrocyte: Neuron Interactions in the Juvenile Form of Batten Disease
… (JNCL), which is caused by a mutation in the Cln3 gene, this astrocyte response appears to be compromised. Since astrocytes are crucial for the functioning and survival of neurons, and emerging evidence highlights the pivotal role that reactive astrocytosis plays in the pathogenesis of CNS …
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Pathogenic impact of immune-related cells in Batten disease
… Infantile NCL (Ppt1-/- mice) and Juvenile NCL (Cln3-/- mice) by identifying, localising, and subsequently genetically removing immune components. Characterising the adaptive immune response within Ppt1-/- and Cln3-/- mice, we revealed evidence for progressive CNS infiltration by different …
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A Genetic and Molecular Analysis of the Control of the Start of the Cell Cycle in Saccharomyces cerevisiae
… transition, since cln1 cln2 strains require both CLN3 and CLB5 for viability on glycerol media, and cln1, 2, 3- strains require CLB5 for rescue by the D. melanogaster cdc2 gene. The other CEN plasmid clone rescuing the cln1, 2, 3- genotype contained MPK1, already known as a gene which could …
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INHIBITING THE NUCLEAR RECEPTOR ESRRA RESCUES CORE PATHOLOGIES IN CELLULAR AND ANIMAL MODELS OF BATTEN DISEASE
… which silence specific genes) in a human ARPE-19 CLN3 knockout (CLN3KO) cell model. The survey identified 84 candidate genes whose depletion reduced Gb3 levels. We focused on the top candidate hit, Estrogen-related receptor alpha (ESRRA/ESRRA), a nuclear receptor involved in mitochondrial …
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Cell Size Control And Asymmetric Cell Fates In Start Of The Saccharomyces cerevisiae Cell Cycle
… modules and showed that different G1 cyclins, CLN3 vs. CLN1 and CLN2, control the two modules. We also showed how positive feedback of G1 cyclins CLN1 and CLN2 on their own transcription ensures a fast transition between the two modules and a coherent commitment to cell cycle progression. …
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Temporal organization of the budding yeast cell cycle: general principles and detailed simulations
… cycle such as: the synthesis of cyclins (Cln1,2; Cln3; Clb1,2; Clb5,6) by their transcription factors (SBF, Mcm1, MBF); their association with stoichiometric inhibitors (Sic1, Cdc6); their degradation by SCF and adaptors of the APC (Cdc20, Cdh1). The emphasis was put on mechanisms responsible for …
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Chromosome dynamics of the early meiotic cell cycle in S. cerevisiae
… of the replication inhibitor HU revealed a Cln3-dependent inhibition of meiotic entry. To map the locations of meiotic DSBs, I developed a method to detect meiotic ssDNA. Examination of the sites of ssDNA enrichment indicated that DSBs occur mainly in the promoters of active genes, …