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Showing 1 to 4 of 4 for “"CLCA2"”.
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HUMAN CLCA2 IS A P53-DEPENDENT ZINC METALLOPROTEASE AND ITS INTERACTION WITH EVA1 MAINTAINS DIFFERENTIATION OF HUMAN MAMMARY EPITHELIAL CELLS
CLCA2 is a p53-inducible transmembrane protein that is frequently downregulated in breast cancer. CLCA2 is a 943 amino acid type I transmembrane protein that is cleaved near amino acid 700 to produce a diffusible 100kD product. The N-terminus contains a hydrolase-like domain with well-conserved …
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HUMAN CLCA2 MODULATES THE CONDUCTANCE OF CALCIUM-ACTIVATED CHLORIDE CHANNELS BY REGULATION OF INTRACELLULAR CALCIUM
… downregulated in cystic fibrosis patients. Human CLCA2 is also expressed in epithelium of airways and mammary glands, and there it promotes calcium-activated chloride current. Hence, we hypothesized that CLCA2 modulates the conductance of Ano1. We tested this by introducing Ano1 and CLCA2 together …
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The role of hCLCA2 and hCLCA4 in suppression of breast cancer progression
hCLCA2 and hCLCA4 are chloride channel regulators that are expressed in normal breast epithelial cells and frequently downregulated in breast cancers. Recent investigations revealed that these two proteins may have a role in suppressing breast cancer progression. In this thesis, I will address …
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Identification of Subclass-Specific Biomarkers by Developing an Integrated Database of Breast Cancer
… expressed and tumor suppressor genes like MUCL1, CLCA2 and DLK1 were down expressed in ERBB2 negative class. In case of a high stage case, overexpression of cancer metastasis related genes including MMP12 and BCL2A1, CXCL5 are observed. On the other hand, FOS, which known as oncogenes, and TFF2, …