Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"CKB"”.
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Extracellular Metabolic Energetics Can Promote Cancer Progression
… downstream effector gene, Creatine Kinase Brain (CKB). CKB was found to promote metastasis and the second part of this thesis present mechanistic studies that describe CKB-mediated modulation of intra- and extracellular energetics by colon cancer cells that contributed to colon cancer cell …
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Mechanisms of Evasion: Anti-Tumor Immune Suppression & TRNA-Dependent Growth in Cancer Metastasis
… We observe that the creatine kinase brain-type (CKB) enzyme, which is over-expressed by colorectal cancer cells suppresses anti-tumor immunity. CKB localizes to the surface of cancer cells and can also be released into the extracellular space. This kinase enzymatically consumes extracellular …
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Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis
… interest, creatine kinase brain isoform (Ckb) was down-regulated in KO cells >100 fold and >2 fold in end-stage tumors. Transplantation of Ckb knockdown (KD) PyMT cells to the mammary fat pad delayed initiation of palpable tumors by >30 days. When cells were introduced into the circulation …
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Associations between socioeconomic status and prevalence, incidence and complications of type 2 diabetes in China
… in 2011-2012 and China Kadoorie Biobank (CKB) in 2004-2008 to describe the association between SES (measured by educational level and household expenditure in CHARLS, and educational level and household income in CKB) and prevalent type 2 diabetes in mainland China. Then, I used …
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Effect of dietary zinc or pyridoxine deficiency upon estrogen directed gene expression in the rat uterus
… In addition the steady state level of <i>ckb</i> mRNA in uteri cytosol fractions was measured following estrogen administration. The weight gain of the rats fed the low zinc and low pyridoxine diets was significantly lower than those fed the zinc-adequate diet ad libitum. The consumption …
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Theories and Experiments of Cognitive Knowledge Bases for Machine Learning
… and experiments on cognitive knowledge bases (CKBs) for machine knowledge learning in cognitive computing and computational linguistics. CKB is both the results and the means of machine learning methodologies mimicking human learning and semantic comprehensions. Technologies for machine …
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Development of prediction models for cardiovascular disease risk in China
… areas in 2004-2008 from China Kadoorie Biobank (CKB). Main results: There are significant regional variations in the mortality rate, composition (proportion of IHD and stroke), and epidemiological patterns of CVD in China. More importantly, the disparity in the epidemiology of CVD among Chinese …