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Showing 1 to 8 of 8 for “"CK2 phosphorylation"”.
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The Role of Post-Translation Regulation of Twist Expression In The Tumor Progression of Squamous Cell Carcinoma of Head and Neck
… ), we found that TWIST has a putative phosphorylation site for casein kinase 2 (CK2) suggesting that this kinase could serve as a link between IL-6 stimulation and Twist stability. To test this hypothesis, we used a CK2 inhibitor and shRNA to CK2 and found that these interventions …
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The Mechanism of Assembly of the G-Protein Beta Gamma Subunit Dimer by CK2 Phosphorylated Phosducin-Like Protein and the Chaperonin Containing TCP-1
… in assembly of the G-protein beta gamma dimer. Phosphorylation of PhLP at serine residues 18-20 by the casein kinase 2 (CK2) appears to play an essential role in this process. PhLP has also been shown to interact with the chaperonin containing TCP-1 (CCT) atop its apical domain, not entering the …
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The Role of Phosducin-like Protein as a Co-chaperone with the Cytosolic Chaperonin Complex in Assembly of the G Protein βγ Subunit Dimer
… subunit and that assembly is dependant upon the phosphorylation of PhLP by the protein kinase CK2. Variants of PhLP lacking the CK2 phosphorylation sites, or variants with an inability to bind Gβγ block the assembly process and inhibit G protein signaling. PhLP forms a complex with CCT and …
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Coordinate regulation of Vegf signalling genes by the proline rich homeodomain protein
… modulation of VEGF and VEGF receptor signalling. CK2 is a stress-activated protein kinase with pleiotropic activity and CK2 phosphorylation of PRH inhibits its DNA binding activity. Here I show that CK2 can antagonise PRH induced cell death and transcriptional regulation. Furthermore I show that …
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Multiple Functions of BRD4 in E2 Mediated HPV Transciptional Regulation
… of Brd4: the E2-interacting domain (E2ID) and phosphorylation-dependent interacting domain (PDID). While E2ID binds to all different types of E2 proteins, PDID interacts only with high risk E2 (HRE2) in a casein kinase 2 (CK2) phosphorylation-dependent manner. In addition to HRE2-specific …
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The Role of Nucleolin Phosphorylation by CK2 in Regulating Cellular Fate Under Normal and Stress Conditions
… dissertation, I elucidate the role of nucleolin phosphorylation by casein kinase 2 (CK2) in controlling cellular fate by regulating p53 checkpoint under normal and stressed conditions. First, I demonstrate that the six consensus CK2 sites on the N-terminus of NCL are important for cell survival …
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Interactions between Folate Deficiency and β-Nicotinamide Adenine Dinucleotide Deficiency and Conformational Study of Thymidylate Synthase and its Physiological Relevance
… by the protein kinase, casein kinase 2 (CK2). Phosphorylation of the enzymes by CK2 was analyzed by isoelectrofocusing. A191K showed multiple phosphorylation sites while hTS and R163K only showed one site, indicating that phosphorylation by CK2 is conformation-selective.</p> <p>After …
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The Role of Phosducin-like Protein and the Cytosolic Chaperonin CCT in G beta gamma dimer Assembly
… beta gamma dimer expression and dimer formation. Phosphorylation of PhLP at serines 18—20 by protein kinase CK2 was required for G protein beta gamma dimer formation, while a high-affinity interaction of PhLP with CCT appeared unnecessary. Interestingly, G protein beta subunit was found to …