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Showing 1 to 20 of 34 for “"CK2"”.
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Plasmodium falciparum protein kinase CK2
… 2007). This study investigates protein kinase CK2 of Plasmodium falciparum, seeking to establish by reverse genetics and biochemical approaches whether it represents a possible antimalarial drug target. Protein-kinase CK2, formerly known as Casein Kinase II, is a dual-specificity …
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The regulation of RNA polymerase III transcription by protein kinase CK2
… of pol III transcription by the protein kinase CK2.
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Novel Proteolysis Targeting Chimeras for the targeted degradation of the protein kinase CK2
Human protein kinase CK2 is a constitutively active serine/threonine kinase involved in numerous biological processes and is frequently overexpressed in a multitude of different cancer types. Traditional ATP-competitive CK2 inhibitors, such as CX-4945, have demonstrated therapeutic potential, but …
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TGA2 dual activity: N-terminus regulation of reversible DNA binding influenced by NPRI and CK2
… domain when phosphorylated by Casein Kinase II (CK2). The mechanisms involved for directing a switch from basal repressor to activator, and the role of kinase activity, have not previously been looked at in detail. This study provides evidence for the involvement of a CK2-like kinase in the …
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The Role of Nucleolin Phosphorylation by CK2 in Regulating Cellular Fate Under Normal and Stress Conditions
… of nucleolin phosphorylation by casein kinase 2 (CK2) in controlling cellular fate by regulating p53 checkpoint under normal and stressed conditions. First, I demonstrate that the six consensus CK2 sites on the N-terminus of NCL are important for cell survival and proliferation. Expression of CK2 …
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A Fragment-Based Drug Discovery Approach for the Development of Selective Inhibitors of Protein Kinase CK2
… of the ATP-binding site. Protein kinase CK2 is a ubiquitously expressed and constitutively active regulator of cell growth, proliferation and apoptosis. Elevated levels of CK2 protein and activity have historically been involved in human cancer, including lung, cervical and head and neck …
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Funktionelle Charakterisierung der CK2-vermittelten Phosphorylierung des Transkriptionsfaktors TIF-IA bei der Regulation der Synthese ribosomaler RNA
… die Serine 170 und 172 durch Casein-Kinase 2 (CK2) in vitro und in vivo phosphoryliert werden. Die Analyse der transkriptionellen Aktivität sowie die Expression von TIF-IAS170A/S172A in TIF-IA knockout Zellen ergaben, daß TIF-IA ohne die CK2-vermittelte Phosphorylierung nicht funktionell ist. …
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Coordinate regulation of Vegf signalling genes by the proline rich homeodomain protein
… modulation of VEGF and VEGF receptor signalling. CK2 is a stress-activated protein kinase with pleiotropic activity and CK2 phosphorylation of PRH inhibits its DNA binding activity. Here I show that CK2 can antagonise PRH induced cell death and transcriptional regulation. Furthermore I show that …
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The Role of Post-Translation Regulation of Twist Expression In The Tumor Progression of Squamous Cell Carcinoma of Head and Neck
… phosphorylation site for casein kinase 2 (CK2) suggesting that this kinase could serve as a link between IL-6 stimulation and Twist stability. To test this hypothesis, we used a CK2 inhibitor and shRNA to CK2 and found that these interventions inhibited IL-6 stimulation of TWIST stability. …
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The Molecular Consequences of CK2-mediated Phosphorylation of the TGA2 Transcription Factor within Systemic Acquired Resistance of Arabidopsis thaliana
… mechanism by introducing protein kinase CK2 into this process. This enzyme efficiently phosphorylates TGA2 resulting in two crucial events. Firstly, the DNA-binding ability of this transcription factor is completely abolished explaining how the large TGA2 complexes are quickly evicted …
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Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc
… functional analysis, we found casein kinase 2 (CK2) is another potential PARP1 regulator. The combination of a CK2 inhibitor (CK2i) and PARPi synergistically attenuates DNA damage repair, cell cycle, cell proliferation and xenograft tumor growth. Similar to the c-Met-PARP1 axis, CK2 interacts …
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Pharmacological inhibition of CK2: the effect of an FDA designated orphan drug on pathology, neuroinflammation, and glial phenotypes in Huntington’s disease
… in our lab, we identified Protein Kinase CK2 as an important kinase involved in the pathophysiology of HD. Specifically, the alpha prime catalytic subunit of CK2 (CK2α’) is upregulated in HD, and genetic depletion of CK2α’ in HD mice results in improved motor behavior, decreased mutant Htt …
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The Mechanism of Assembly of the G-Protein Beta Gamma Subunit Dimer by CK2 Phosphorylated Phosducin-Like Protein and the Chaperonin Containing TCP-1
… at serine residues 18-20 by the casein kinase 2 (CK2) appears to play an essential role in this process. PhLP has also been shown to interact with the chaperonin containing TCP-1 (CCT) atop its apical domain, not entering the substrate folding cavity. However, the physiological role of the …
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Approaches Towards the Inhibition of Anti-Apoptotic Proteins
… 1) Inhibition of the anti-apoptotic protein CK2 to develop novel anti-cancer molecules targeting pockets outside the well-conserved ATP-binding site: -Using a Fragment-Based-Drug-Discovery (FBDD) approach twelve small molecule inhibitors of CK2 were developed. The lead molecule, 3l, inhibited …
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Cardiac Calsequestrin Phosphorylation And Trafficking In The Mammalian Cardiomyocyte
… the identity of CSQ2 kinase as protein kinase CK2. In vitro, inhibition of CSQ2 phosphorylation using cardiomyocyte and nonmuscle cell CSQ2 kinase sources was successfully carried out with three specific inhibitors of CK2: TBB, DMAT and TBCA. TBCA produced identical inhibition curves for both …
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The Role of Phosducin-like Protein as a Co-chaperone with the Cytosolic Chaperonin Complex in Assembly of the G Protein βγ Subunit Dimer
… phosphorylation of PhLP by the protein kinase CK2. Variants of PhLP lacking the CK2 phosphorylation sites, or variants with an inability to bind Gβγ block the assembly process and inhibit G protein signaling. PhLP forms a complex with CCT and nascent Gβ prior to the release of Gβγ from the …
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Protein-Protein-Interaktionen in den 'Gating'-Domänen von Kaliumkanälen
… Interaktionspartnern wurde Caseinkinase II (CK2) zweifelsfrei als Protein bestätigt, das direkt mit den SK2 alpha-Untereinheiten assoziiert ist. Zusätzlich gibt es Hinweise für eine spezifische Interaktion mit Proteinphosphatase 2A (PP2A). <br>Durch In-vitro-Phosphorylierung und …
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Autosomal dominante polyzystische Nierenerkrankung : der Transport von Polyzystin 2 wird phosphorylierungsabhängig von PACS-1 reguliert
… der Bindungsdomäne durch die Protein Kinase CK2. Ein Austausch saurer Aminosäuren durch ungeladene oder eine Zerstörung der Protein Kinase CK2 Phosphorylierungsstelle führte zu einer Unterdrückung der PACS-1 - Polyzystin 2 Interaktion und zu einer Umverteilung von Polyzystin 2 vom …
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Development And Study Of Inhibitors Of Heat Shock Protein 70 Induction
… were also found to be inhibitors of both Ck2 kinase and CaMKII kinase that are known to activate heat shock transcription factor 1 that leads to HSP70 induction. A biotinylated quercetin affinity agent was also developed that was able to pull down the CK2 kinase target in vitro and several …
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