Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"CK1"”.
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The Role of CK1 in Necroptosis and Confirmation of Amyloid-Like Fibers in Necroptosis Using 2D SDD-AGE
… of RIPK3 reveals that casein kinase 1 (CK1) family proteins associate with the necrosome upon necroptosis induction, and this interaction depends on the kinase activity of RIPK3. In addition, CK1 proteins colocalize with RIPK3 puncta during necroptosis. Importantly, CK1 proteins directly …
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Identification and characterisation of FAM83 proteins as key regulators of CK1 protein kinases in cells: FAM83D recruits CK1α to the mitotic spindle for proper spindle positioning
… to different isoforms of the casein kinase 1 (CK1) family of Ser/Thr protein kinases and direct them to the distinct cellular sites in which the FAM83 proteins reside. FAM83 members mediate CK1 binding through their conserved DUF1669. In this capacity, FAM83 proteins may act as the A Kinase …
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Investigating FAM83H, a protein mutated in Amelogenesis Imperfecta
… with different isoforms of the protein kinase CK1 (formerly known as Casein Kinase 1) family via the DUF1669 domain. It is believed that FAM83 proteins may act as subcellular anchors and key regulators of CK1 isoforms. CK1 is thought to be a constitutively active serine/threonine protein kinase …
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Elucidating the biological function of the uncharacterised protein FAM83G/PAWS1: Role in Wnt signalling through its interaction with Caseine Kinase 1α
… of the transcriptional co-factor β-catenin by CK1 and GSK3 results in the ubiquitylation of β-catenin, priming it for degradation via the proteasome. Upon Wnt-activation, β-catenin is stabilised and translocates to the nucleus, where it associates with TCF and LEF and regulates the expression …
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Understanding Host-Pathogen Interactions of Rift Valley Fever Virus That Contribute to Viral Replication
… production and not entry or egress. Conversely, CK1α and PP1α were identified as binding partners of the L protein using similar methods. CK1α, a kinase, and PP1α, a phosphatase, were chosen for further verification due to data demonstrating the L protein is phosphorylated on at least one serine …
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Protein kinases that phosphorylate 14-3-3 isoforms
… /threonine protein kinase Casein kinase la (CK1 a) was shown to negatively affect the interaction with Raf kinase. The group of Gotoh have recently shown that phosphorylation of S185 by the stress activated kinase c -Jun NH2- terminal kinase (JNK) negatively effects the interaction with Bax. …
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COMPARATIVE CELL BASED FUNCTIONAL ANALYSIS OF KEY WNT/BETA-CATENIN PATHWAY GENES AND GENE MUTATIONS
… by GSK3 Beta; in a complex with APC, AXIN, and CK1. Phosphorylation promotes ubiquitination of Beta-catenin and subsequent proteasomal degradation. When a Wnt-ligand binds to a Frizzled receptor, a signaling cascade displaces GSK3 Beta from its complex with Beta-catenin allowing Beta-catenin …
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Generation of chickenized 3D8 scFv antibody from mouse monoclonal anti-DNA antibody by CDRs-grafting
… culture. CK6 of chickenized 3D8 scFv variant (CK1~7) retained the DNA-binding, DNA-hydrolysis, and cellular internalizing activities similar to that of the original mouse 3D8 scFv (m3D8). Our results demonstrate that chckenized 3D8 scFv can be generated by grafting CDRs.
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Exploiting Chemical Libraries to Identify and Characterize Novel Bioactives with Efficacy Against Pathogenic Candida Species
… inhibited C. albicans Yck2 over the human CK1 isoform, CK1α. Collectively, this work highlights molecules with efficacy against diverse fungal pathogens, which may pave the way for future antifungal drug development.
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Wnt-5a signaling in breast cancer metastasis
… is mediated through activation of Yes, Cdc42 and CK1?. Furthermore, based on sequence analysis of the Wnt-5a protein, I identified two peptides with Wnt-5a mimicking ability. One of the peptides was shortened and modified to yield the formylated hexapeptide, Foxy-5, which was able to copy the …
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Kininogen and Ferritin in Tumorigenesis
… activator receptor (uPAR, CD87), cytokeratin 1(CK1), globular “head” of C1q (gC1q-R) and tropomyosin, of which uPAR is the most studied and most relevant to tumorigenesis. Tumor cells frequently overexpress uPAR. The work presented here focuses on the effects of HKa and ferritin on cancer cells …
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TDP-43 and its role in neurodegeneration
… Drosophila homologue of Casein Kinase 1- (CK1-), dbt, is a “specific kinase” that phosphorylates “disease-specific site S409/410” and in particular phosphorylation of S409/410 by dbt correlates to severe toxic eye phenotype and partial lethality in ALS mutant Q331K. Our results suggest …
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T-Zell-priming außerhalb sekundärer lymphatischer Gewebe
… vermutlich durch die Überexpression der DC CK1 und SDF1 Chemokinen in den Injektionsstellen, die chemotaktisch auf T-Zellen wirken, angezogen. Das Infiltrat in den Injektionsstellen war oligoklonal und wies tumorspezifische T-Zellen auf. Nachdem diese T-Zellklone im Blut der Patienten vor …
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Zwei neuartige Aspartylproteasen BACE-1 und BACE-2
… In vitro werden beide Enzyme durch CK1 an homologen Serinen in der zytoplasmatischen Domäne phosphoryliert. Während für BACE-2 bisher nicht schlüssig gezeigt werden konnte, dass auch in vivo eine Phosphorylierung erfolgt, wurde für BACE-1 S498 auch als Phosphorylierungsstelle in vivo …