Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CITE-seq"”.
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Systems immunology frameworks link multicellular immune perturbation phenotypes and setpoints to response outcomes
… measure protein and mRNA in single cells (e.g., CITE-seq). After identifying two main sources of noise, we develop an open source software method for normalizing and denoising CITE-seq protein data. We then develop a computational framework for analyzing the effects of timed immune system …
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Scalable Machine Learning Methods For The Analysis Of Single-Cell Transcriptomics And Multiomics Data
… otherwise confounded in lower-resolution, bulk sequencing technologies. Previously, investigators studied human cell populations by profiling RNA expression in single cells using single-cell RNA sequencing (scRNA-seq) technologies. More recently, multi-modality sequencing technologies such as …
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Experimental Design for Optimal Shift Intervention in Causal Model
… more precisely gene expression data from Perturb-CITE-seq experiments. In this case the goal is to identify optimal perturbations to induce a specific cell state transition; the proposed causal approach is observed to achieve better sample efficiency compared to several baselines. In both cases we …
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Molecular Characterisation and Therapeutic Targeting of NPM1-mutant Acute Myeloid Leukaemia
… Despite their prevalence, the molecular consequences of NPM1 mutations (NPM1c) are incompletely understood and this hinders progress in designing effective therapeutic strategies. This thesis describes my work to characterise NPM1-mutant cells at the molecular level using different omics …
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Single-cell Protein-Transcriptome Atlas of Haematopoiesis across the Human Lifespan
… single-cell level using a combination of scRNA-seq and index sorting has proven valuable for inferring individual cellular states and identifying subpopulations for further research. Nevertheless, traditional methods that measure both transcripts and proteins from single cells via index …
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Single-cell atlasing of the human tissues across the lifespan
Single-cell and spatial sequencing have revolutionised our understanding of human tissue biology in recent years. The Human Cell Atlas (HCA) initiative aims to recover and position all of the cell types in the human body. Being part of HCA, I have worked on building atlases which allow comparison …