Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"CIS-regulation"”.
-
cis-Regulation in the Mammalian Rod Photoreceptor
… level of target genes by binding to <italic>cis</italic>-regulatory elements (CREs) present in gene promoters. The goal of my thesis research is to define the sequence components of CREs that determine transcriptional output. In order to accomplish this goal, I developed a method to measure …
-
Hierarchy and CIS-Regulation in Drosophila Segmentation: Rules for Pattern Formation and Clues to Evolution
… few systems is it possible to analyze the global cis-regulatory structure of developmental transcription networks. One system where this is in principle possible is segmentation in Drosophila melanogaster, although to date such an undertaking has not been attempted. Here using computational …
-
The genetic and developmental bases of male genital organ size evolution
… Moreover, expression analysis of trn implies cis-regulatory evolution, and likely candidate trn enhancer has been identified. Therefore, this thesis provides insights into the cis-regulation of phenotypic divergence, and given that trn functions as a cell affinity molecule, this may represent …
-
Genomic Regulation of the Shox2 Gene during Mouse Limb Development
… the principal architects of transcriptional regulation, are as important as protein-coding sequences in the etiology of developmental diseases. Conditional knockout of murine Shox2 in limbs specifically disrupts chondrogenesis and the development of the humerus and femur, and is …
-
Developmental and Expression Evolution in C3 and C4 Atriplex and their Hybrids
… expression analysis to investigate the role of cis- and trans-regulatory effects on gene expression divergence. The majority (~80%) of expression divergence between C3 and C4 species arose from cis-only regulatory divergence, suggesting that numerous independent expression changes across the …
-
Developmental Basis of Wing Pattern Diversity in Heliconius Butterflies
… to create diversity: first, at the level of cis-regulation, second at the level of gene interaction and expression, and lastly at the level of developmental bias and constraint.
-
Regulation and function of genes involved in drosophila ciliogenesis
… in the gene regulatory network, I analysed the regulation and function of these genes. First, I demonstrated that both Rfx and dila are activated during Ch neurogenesis as direct targets of Ato. This was established by characterising their expression patterns, cis-regulation analyses and …
-
Transcriptional divergence during cichlid embryogenesis
… to assess the relative contributions of cis- and trans-regulation to gene expression variation during early cichlid development. This analysis shows an enrichment of genes with compensatory expression and stronger influence of trans-regulation over cis-regulation, highlighting regulatory …
-
Improving Thermodynamic Models of Transcription by Combining ChIP and Expression Measurements of Synthetic Promoters
<p>Regulation of gene expression is a fundamental process in biology. Accurate mathematical models of the relationship between regulatory sequence and observed expression would advance our understanding of biology.</p><p>I developed ReLoS, a regulatory logic simulator, to explore mathematical …
-
Computational modeling of gene expression from regulatory sequences
Regulation of gene expression is an important early step in controlling every biological process that underlies the function of living organisms. Even though gene expression may be regulated in several stages, the modulation occurs mostly at the primary stage known as “transcription”. Teasing out …