Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"CIPN"”.
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Kratom Alkaloid Mitragynine: Therapeutic Role and Potential Utility Against Chemotherapy-Induced Peripheral Neuropathy
… chemotherapy-induced peripheral neuropathy (CIPN) persists as a monumental public health crisis, as it is the most common comorbidity among those receiving chemotherapy for cancer treatment. CIPN is unique compared to other forms of neuropathic pain in that it is severely dose-limiting, often …
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Effects Of Chemotherapy-Induced-Peripheral-Neuropathy On Spatiotemporal Gait Parameters And Fall Risk In Cancer Patients After The Completion Of Chemotherapy Drug Treatment
… participated in the present study. There were 8 CIPN subjects between the ages of 50–70 years of age who had a histologically confirmed stage 2–3 breast or colorectal cancer diagnosis with a confirmed treatment plan consisting of taxane- or oxaliplatin-based chemotherapy. Controls consisted of 8 …
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Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female ratsa role for the endocannabinoid system
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and debilitating side effect of cancer treatment, often persisting for months after therapy cessation and profoundly impairing quality of life. Among chemotherapeutic agents, paclitaxel (PTX) stands out for its broad clinical use …
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Impact of environmental and genetic factors on pain sensitivity and chronic pain development
… Chemotherapy-induced neuropathic pain (CIPN) is a common and debilitating side effect of chemotherapy treatment. However not all patients develop CIPN, and for those that do, severity varies. Cancer patients often undergo surgery prior to chemotherapy. A prior adult injury has been …
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Mechanisms of Astrocyte Contribution to Bortezomib-Induced Peripheral Neuropathy
… by chemotherapy-induced peripheral neuropathy (CIPN) that may be dose-limiting, adversely affecting quality of life and prognosis. The mechanisms behind bortezomib-induced peripheral neuropathy (BIPN) and CIPN overall are largely unknown. Recent findings in other pain models have indicated …
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Immune contributions of the meninges and choroid plexus in animal models of central and peripheral nervous system neuropathy
… of chemotherapy-induced peripheral neuropathy (CIPN). The immune profile of the meninges, CP, and lymphoid tissue was compared across male and female mice in acute stages of CCI and in a chronic model. We found the immune profile of the meninges, CP, and lymphoid tissue at acute stage of injury …
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THE USE OF PREVENTATIVE CANNABIDIOL, CANNABIGEROL, AND MITRAGYNINE TO AMELIORATE MECHANICAL SENSITIVITY OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN FEMALE MICE
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of cytotoxic chemotherapy drugs. It has been reported that >60% of patients receiving chemotherapy suffer from this debilitating condition, which manifests itself in a polyneuropathy of paresthesia, hyperalgesia, …
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Autocatalytic closure and the evolution of cellular information processing networks
Cellular Information Processing Networks (CIPNs) are chemical networks of interacting molecules occurring in living cells. Through complex molecular interactions, CIPNs are able to coordinate critical cellular activities in response to internal and external stimuli. We hypothesise that CIPNs may be …
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PULMONARY DELIVERY OF RESVERATROL-LOADED NANOCOMPOSITE MICROPARTICLES TO TREAT LUNG CANCER
… and chemotherapy-induced peripheral neuropathy (CIPN), which can range from life-altering to life-threatening. Moreover, the economic impact of current cancer chemotherapy is unsustainable and, thus, an alternative therapy for lung cancer need to be investigated. Towards this goal, resveratrol …
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Multiple Myeloma and Its Treatment Alter Peripheral Nervous System Structure and Function
… Chemotherapy-induced peripheral neuropathy (CIPN) refers to the collection of symptoms (e.g. pain, paresthesias and dysesthesias) that develop in distal, glabrous (non-hairy) skin of 20 to 100% of patients treated with chemotherapy. Peripheral neuropathy negatively impacts quality of life in …