Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 85 for “"CIN"”.
-
Targeting chromosomal instability: screening and characterization of CIN killers.
Chromosomal INstability (CIN), a hallmark of cancer cells, refers to a state in which cells have an increased rate of gain or loss of whole chromosomes or large chromosomal fractions. CIN is linked to the progression of tumours with poor clinical outcomes such as drug resistance and metastasis. …
-
Δράση των στατινών στην πρόληψη της οξείας νεφρικής βλάβης επαγόμενης από σκιαγραφικά μέσα (CIN)
… ιδιότητες) και οι επιδράσεις τους στην CIN αξιολογήθηκαν σε αρκετές μελέτες με αντικρουόμενα αποτελέσματα. Σκοπός: Σκοπός της μελέτης ήταν να διερευνηθεί η ύπαρξη ευεργετικής δράσης της χρόνιας χρήσης στατινών σε ασθενείς που εμφάνισαν οξύ στεφανιαίο επεισόδιο (ΟΣΣ) και οι οποίοι …
-
Investigating the Relationship Between Calorie Restriction and Mitotic Protein BubR1 in the Prevention of CIN-Induced Tumorigenesis
It is a widely known observation that aging is accompanied by decreased cellular fitness and heightened risk of acquiring diseases such as cancer. Despite this, the contributing factors that define this relationship are complex and largely undefined. Genomic and chromosomal instability in the form …
-
Pharmakokinetische, fluoreszenzmikroskopische Studie zur Gewebeaufnahme und Verteilung von 5-Aminolävulinsäure aus 5-ALA-Thermogel bei zervikaler intraepithelialer Neoplasie (CIN 1-3)
… neue Methoden zur Detektion und Behandlung von CIN-Läsionen. Sie erfolgen nach Applikation einer photosensibilisierenden Substanz vor der Portio und einer Illumination mittels Laserlicht einer definierten Wellenlänge. In den von uns durchgeführten Untersuchungen wurde als photosensibilisierende …
-
The Prevalence Of Hpv Associated Disease In Women Under Age 21: Who Will Be Missed Under The New Cervical Cancer Screening Guidelines?
… lesions or cervical intraepithelial neoplasia (CIN) 2+/AIS in the state of Connecticut and identify any correlates which may be associated with CIN 3.</p> <p>Methods: CIN 2+/AIS precancerous cervical lesions are a reportable condition in the State of Connecticut for the purpose of public health …
-
Telomeric Regulation of Chromosomal Instability In Colorectal Cancer
… dysfunction drives chromosomal instability (CIN) during the transition from benign adenoma to malignant adenocarcinoma. While CIN provides a mutator mechanism for cancer-relevant genomic events, its role in shaping tumor biology during carcinogenesis is not well understood. Here, we explored …
-
Targeting the human papillomavirus for prevention of cervical cancer
… vary in the extent they cause precursor lesions (CIN) and cancer. There are limited long-term efficacy data on HPV testing in primary screening Among 72 cervical cancers in Mozambique, HPV 16 and 18 were the most frequent HPV types (69% of cases). Comparing 108 cervical cancers cases and 517 …
-
Human papillomavirus testing and its application in cervical cancer prevention
… (HPV) and cervical intraepithelial neoplasia (CIN) and cancer, HPVtesting has been proposed for improvement of cervical screening programs, including triaging and follow-up after treatment for CIN. We developed two new methods for HPV-testing with genotyping: A high-throughput HPV genotyping …
-
A Study of Histopathologic Outcomes of Women With Cryotherapy-Ineligible lesions on Cervicography
… high grade cervical intraepithelial neoplasia (CIN 2+) and individual acetowhite cryotherapy-ineligible lesion types, as determined by cervicography.Design: a cross sectional study Setting: Gynecologic Cancer Prevention Unit of the University Teaching Hospital, Zambia.Population: Women referred …
-
A Study of Histopathologic Outcomes of Women With Cryotherapy-Ineligible lesions on Cervicography
… high grade cervical intraepithelial neoplasia (CIN 2+) and individual acetowhite cryotherapy-ineligible lesion types, as determined by cervicography.Design: a cross sectional study Setting: Gynecologic Cancer Prevention Unit of the University Teaching Hospital, Zambia.Population: Women referred …
-
Signatures of chromosomal instability in human cancers
Chromosomal instability (CIN), defined as the process of losing or gaining whole or parts of chromosomes, is one of the earliest molecular characteristics to be described in cancer. Since its detection by light microscopy in the late 19th century, technological advances have facilitated the …
-
Deep learning for digitized histology image analysis
… of cervical intraepithelial neoplasia (CIN) through histopathology remains as the standard for absolute determination of cancer. The examination of tissue samples under a microscope requires considerable time and effort from expert pathologists. There is a need to design an automated …
-
Mid West–Gascoyne District police officers’ experience with the Cannabis Infringement Notice Scheme
… Australia (WA) Cannabis Infringement Notice (CIN) scheme commenced in 2004. The introduction of the CIN scheme as part of the Cannabis Control Act 2003 (WA) aimed to divert minor, first-time cannabis offenders into cannabis education sessions. As police are gatekeepers to the criminal justice …
-
Computational Analysis of Genome-Wide DNA Copy Number Changes
… two definitions of chromosome instability (CIN) index to mathematically and quantitatively characterize genome-wide genomic instability. The proposed CIN indices are derived from detected CNAs using circular binary segmentation and wavelet transform, which calculates a score based on both …
-
Cellular immune responses to human papillomavirus (HPV) type 16 at the cervix of women with HPV-associated squamous intraepithelial neoplasia
… with 84% of cervical intraepithelial neoplasia (CIN). HPV type 16 (HPV-16) is the most prevalent HPV type associated CIN and cervical cancer with ±56% of women with cervical disease being infected with HPV 16. Yet studies have shown that 47-85% of CIN regressed, suggesting that perhaps an …
-
Chromosomal instability and tumorigenesis : genetic analysis of the murine spindle checkpoint gene Mps1
… checkpoint can cause chromosomal instability (CIN), the frequent gain or loss of entire chromosomes during cell divisions. While CIN has been proposed to be sufficient to initiate tumorigenesis, no direct evidence has shown that CIN itself is a causal agent for human cancer. To determine if CIN …
-
Biomarkers of Genome Instability and Disease Progression in Ovarian Cancer
High grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer and the major cause of gynaecological cancer-related deaths in the Western world. Overall survival for HGSOC patients has not improved over the last two decades, and the progressive evolution of chemotherapy …
-
A study of the immune response to human papillomavirus types causing cervical cancer
… with cervical intraepithelial neoplasia (CIN). A significant association with CIN was found for IgG antibodies to an E2 peptide (E2-16, P = 0.039) and HPV-16 virus-like particles (VLP-16, P = 0.002). This association was found to be age-dependant in women with CIN, with a higher antibody …
-
Association of the Cervical Intraepithelial Neoplasia and Human Papillomavirus Viral load
… 상피내 종양 (Cervical intraepithelial neoplasia ; CIN) 1, CIN 2, CIN 3, squamous cell carcinoma인 각각의 군 사이에 임상적 특성에는 유의한 차이를 보이지 않았으나 CIN 등급이 높아질수록 viral load가 증가하는 양상을 보였으며 통계적으로 유의하였다. HPV viral load가 자궁경부 상피내 종양 유무를 진단하는데 대한 민감도, 특이도, 양성예측도, 음성예측도는 각각 82.9%, 37.7%, 60.0%, 66.2%로 나타난 반면에 저등급 병변과 …
-
A comprehensive study of the impact of contrast medium on endothelial cells in vitro: validating the protective effects of n-acetylcysteine and assessing the importance of endothelin-1 and glutathione on contrast-induced nephropathy in patients with chronic kidney disease
Contrast-induced nephropathy (CIN) is a severe complication that can sometimes affect the kidneys of patients following angiographic procedures that involve the administration of iodinated contrast medium (CM) to aid visualisation of blood vessels in medical imaging. CIN represents around 12% of …
Page 1 of 5